Establishment of a tumor sphere cell line from a metastatic brain neuroendocrine tumor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-12

AUTHORS

Ryoichi Iwata, Masato Maruyama, Tomoki Ito, Yosuke Nakano, Yonehiro Kanemura, Taro Koike, Souichi Oe, Kunikazu Yoshimura, Masahiro Nonaka, Shosaku Nomura, Tetsuo Sugimoto, Hisao Yamada, Akio Asai

ABSTRACT

Neuroendocrine tumors are rare, and little is known about the existence of cancer stem cells in this disease. Identification of the tumorigenic population will contribute to the development of effective therapies targeting neuroendocrine tumors. Surgically resected brain metastases from a primary neuroendocrine tumor of unknown origin were dissociated and cultured in serum-free neurosphere medium. Stem cell properties, including self-renewal, differentiation potential, and stem cell marker expression, were examined. Tumor formation was evaluated using intracranial xenograft models. The effect of temozolomide was measured in vitro by cell viability assays. We established the neuroendocrine tumor sphere cell line ANI-27S, which displayed stable exponential growth, virtually unlimited expansion in vitro, and expression of stem-cell markers such as CD133, nestin, Sox2, and aldehyde dehydrogenase. FBS-induced differentiation decreased Sox2 and nestin expression. On the basis of real-time PCR, ANI-27S cells expressed the neuroendocrine markers synaptophysin and chromogranin A. Intracranial xenotransplanted brain tumors recapitulated the original patient tumor and temozolomide exhibited cytotoxic effects on tumor sphere cells. For the first time, we demonstrated the presence of a sphere-forming, stem cell-like population in brain metastases from a primary neuroendocrine tumor. We also demonstrated the potential therapeutic effects of temozolomide for this disease. More... »

PAGES

211-219

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00795-017-0160-0

DOI

http://dx.doi.org/10.1007/s00795-017-0160-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085426754

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28516286


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "AC133 Antigen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aldehyde Dehydrogenase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents, Alkylating", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromogranin A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dacarbazine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplastic Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nestin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuroendocrine Tumors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Primary Cell Culture", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "SOXB1 Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spheroids, Cellular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Synaptophysin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Temozolomide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Kansai Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410783.9", 
          "name": [
            "Department of Neurosurgery, Kansai Medical University, Hirakata, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iwata", 
        "givenName": "Ryoichi", 
        "id": "sg:person.01040370471.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040370471.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kansai Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410783.9", 
          "name": [
            "Department of Anatomy and Brain Science, Kansai Medical University, Hirakata, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maruyama", 
        "givenName": "Masato", 
        "id": "sg:person.013603420311.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013603420311.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kansai Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410783.9", 
          "name": [
            "First Department of Internal Medicine, Kansai Medical University, Hirakata, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ito", 
        "givenName": "Tomoki", 
        "id": "sg:person.01105254153.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105254153.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kansai Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410783.9", 
          "name": [
            "Department of Anatomy and Brain Science, Kansai Medical University, Hirakata, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakano", 
        "givenName": "Yosuke", 
        "id": "sg:person.012445231767.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012445231767.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osaka National Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416803.8", 
          "name": [
            "Division of Regenerative Medicine, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kanemura", 
        "givenName": "Yonehiro", 
        "id": "sg:person.0665013040.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665013040.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kansai Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410783.9", 
          "name": [
            "Department of Anatomy and Cell Science, Kansai Medical University, Hirakata, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koike", 
        "givenName": "Taro", 
        "id": "sg:person.01143402042.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143402042.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kansai Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410783.9", 
          "name": [
            "Department of Anatomy and Cell Science, Kansai Medical University, Hirakata, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oe", 
        "givenName": "Souichi", 
        "id": "sg:person.01003170504.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003170504.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kansai Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410783.9", 
          "name": [
            "Department of Neurosurgery, Kansai Medical University, Hirakata, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshimura", 
        "givenName": "Kunikazu", 
        "id": "sg:person.01075347562.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075347562.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kansai Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410783.9", 
          "name": [
            "Department of Neurosurgery, Kansai Medical University, Hirakata, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nonaka", 
        "givenName": "Masahiro", 
        "id": "sg:person.01266757404.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266757404.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kansai Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410783.9", 
          "name": [
            "First Department of Internal Medicine, Kansai Medical University, Hirakata, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nomura", 
        "givenName": "Shosaku", 
        "id": "sg:person.0637542245.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637542245.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kansai Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410783.9", 
          "name": [
            "Department of Anatomy and Brain Science, Kansai Medical University, Hirakata, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sugimoto", 
        "givenName": "Tetsuo", 
        "id": "sg:person.0662714627.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662714627.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kansai Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410783.9", 
          "name": [
            "Department of Anatomy and Cell Science, Kansai Medical University, Hirakata, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamada", 
        "givenName": "Hisao", 
        "id": "sg:person.0751640414.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751640414.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kansai Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410783.9", 
          "name": [
            "Department of Neurosurgery, Kansai Medical University, Hirakata, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Asai", 
        "givenName": "Akio", 
        "id": "sg:person.01130621242.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130621242.61"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/cncr.29099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001724464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-06-2053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002414313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1139/bcb-2012-0100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002570149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-1476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002930100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(07)70410-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003895716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40001-014-0066-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004430104", 
          "https://doi.org/10.1186/s40001-014-0066-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40001-014-0066-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004430104", 
          "https://doi.org/10.1186/s40001-014-0066-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1600007113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006692555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clineuro.2014.08.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009935552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.03.6046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010536433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12967-016-0857-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023235750", 
          "https://doi.org/10.1186/s12967-016-0857-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2014.60.2532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024132051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.24406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024162135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.24406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024162135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2011.07.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026830472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.3510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027870553", 
          "https://doi.org/10.1038/nn.3510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2012.244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028358194", 
          "https://doi.org/10.1038/bmt.2012.244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/367645a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028822583", 
          "https://doi.org/10.1038/367645a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.20659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032697278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033288252", 
          "https://doi.org/10.1038/sj.bjc.6690325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033288252", 
          "https://doi.org/10.1038/sj.bjc.6690325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pai.0000210416.53493.0f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033760932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pai.0000210416.53493.0f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033760932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth758", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037605769", 
          "https://doi.org/10.1038/nmeth758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth758", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037605769", 
          "https://doi.org/10.1038/nmeth758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.15.4377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037736197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000333035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041278310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4402283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043286075", 
          "https://doi.org/10.1038/sj.cdd.4402283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.11.5964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044289595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2007.08.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045510569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.11105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046798811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.40.3147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047129062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccell.2016.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050525775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/scd.2008.0055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059309834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1553558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062490966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.2012.1592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071512886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.10.9.15486", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072296500"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "Neuroendocrine tumors are rare, and little is known about the existence of cancer stem cells in this disease. Identification of the tumorigenic population will contribute to the development of effective therapies targeting neuroendocrine tumors. Surgically resected brain metastases from a primary neuroendocrine tumor of unknown origin were dissociated and cultured in serum-free neurosphere medium. Stem cell properties, including self-renewal, differentiation potential, and stem cell marker expression, were examined. Tumor formation was evaluated using intracranial xenograft models. The effect of temozolomide was measured in vitro by cell viability assays. We established the neuroendocrine tumor sphere cell line ANI-27S, which displayed stable exponential growth, virtually unlimited expansion in vitro, and expression of stem-cell markers such as CD133, nestin, Sox2, and aldehyde dehydrogenase. FBS-induced differentiation decreased Sox2 and nestin expression. On the basis of real-time PCR, ANI-27S cells expressed the neuroendocrine markers synaptophysin and chromogranin A. Intracranial xenotransplanted brain tumors recapitulated the original patient tumor and temozolomide exhibited cytotoxic effects on tumor sphere cells. For the first time, we demonstrated the presence of a sphere-forming, stem cell-like population in brain metastases from a primary neuroendocrine tumor. We also demonstrated the potential therapeutic effects of temozolomide for this disease.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00795-017-0160-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5872848", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5877036", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1295024", 
        "issn": [
          "1860-1480", 
          "1437-773X"
        ], 
        "name": "Medical Molecular Morphology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "50"
      }
    ], 
    "name": "Establishment of a tumor sphere cell line from a metastatic brain neuroendocrine tumor", 
    "pagination": "211-219", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b466092415edacb106886fb88814e226725f57e1204d5b8d0308ffe5eb53cca1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28516286"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101239023"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00795-017-0160-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1085426754"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00795-017-0160-0", 
      "https://app.dimensions.ai/details/publication/pub.1085426754"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54302_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00795-017-0160-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00795-017-0160-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00795-017-0160-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00795-017-0160-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00795-017-0160-0'


 

This table displays all metadata directly associated to this object as RDF triples.

359 TRIPLES      21 PREDICATES      84 URIs      44 LITERALS      32 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00795-017-0160-0 schema:about N0076f02f00ff4cd685319a60eabd6e9f
2 N19bfb5f3eac443c69521c1e7dad40ef1
3 N2875e32fe9a74d248e1fc1331bb614fe
4 N2d1bb04f4df845928d1cb0aa06eab0ef
5 N3296403aac13447e90582ff25e0f337e
6 N43bdaa7cd5434d66b118707f0a361cb3
7 N4a482dc3fad34d3890fd5dc552a3a7ec
8 N541a9bc43d2549a08ad36e043e22977f
9 N55ddd0b534294f8cb136d2fda083eea7
10 N59315f772ccd4440affd8de702a56bd6
11 N59c8df81287c4dad9074ec8fb6d20e32
12 N602e91c8c0484c19a11492b9b2d7aeeb
13 N6941a0f73cc343e69592e928daa06f40
14 N6aa8f6c62ccd444787b976be51fb8a2a
15 N88b1738be9e2456d9c91addfa3c9b413
16 Nb32711a0f55a4d61be165bdd7f85a103
17 Nb3b7180d91f34e92847213eb4d9a2b04
18 Nb77a505a04da4540b300b87aaa3eee45
19 Nbafc7f7657e94b9fbe87a3b3964eecc2
20 Nc9b35a5b182f45f68b8f7b20049ea2f2
21 Ndd04fece523d4efdbba094116fb9a74b
22 Nf3f1fc7dc42f490bbd38544b16875787
23 Nf40e957ad3a74023a01a68d513c2acfa
24 anzsrc-for:11
25 anzsrc-for:1112
26 schema:author N7182d1f001cf4079b15a27330f6cfdad
27 schema:citation sg:pub.10.1038/367645a0
28 sg:pub.10.1038/bmt.2012.244
29 sg:pub.10.1038/nmeth758
30 sg:pub.10.1038/nn.3510
31 sg:pub.10.1038/sj.bjc.6690325
32 sg:pub.10.1038/sj.cdd.4402283
33 sg:pub.10.1186/s12967-016-0857-1
34 sg:pub.10.1186/s40001-014-0066-4
35 https://doi.org/10.1002/cncr.11105
36 https://doi.org/10.1002/cncr.20659
37 https://doi.org/10.1002/cncr.24406
38 https://doi.org/10.1002/cncr.29099
39 https://doi.org/10.1016/j.ccell.2016.01.005
40 https://doi.org/10.1016/j.clineuro.2014.08.004
41 https://doi.org/10.1016/j.stem.2007.08.014
42 https://doi.org/10.1016/s1470-2045(07)70410-2
43 https://doi.org/10.1053/j.gastro.2011.07.037
44 https://doi.org/10.1073/pnas.1600007113
45 https://doi.org/10.1089/scd.2008.0055
46 https://doi.org/10.1097/01.pai.0000210416.53493.0f
47 https://doi.org/10.1126/science.1553558
48 https://doi.org/10.1139/bcb-2012-0100
49 https://doi.org/10.1158/1078-0432.ccr-06-2053
50 https://doi.org/10.1158/1078-0432.ccr-08-1476
51 https://doi.org/10.1159/000333035
52 https://doi.org/10.1200/jco.2005.03.6046
53 https://doi.org/10.1200/jco.2007.11.5964
54 https://doi.org/10.1200/jco.2007.15.4377
55 https://doi.org/10.1200/jco.2011.40.3147
56 https://doi.org/10.1200/jco.2014.60.2532
57 https://doi.org/10.3892/ijo.2012.1592
58 https://doi.org/10.4161/cc.10.9.15486
59 schema:datePublished 2017-12
60 schema:datePublishedReg 2017-12-01
61 schema:description Neuroendocrine tumors are rare, and little is known about the existence of cancer stem cells in this disease. Identification of the tumorigenic population will contribute to the development of effective therapies targeting neuroendocrine tumors. Surgically resected brain metastases from a primary neuroendocrine tumor of unknown origin were dissociated and cultured in serum-free neurosphere medium. Stem cell properties, including self-renewal, differentiation potential, and stem cell marker expression, were examined. Tumor formation was evaluated using intracranial xenograft models. The effect of temozolomide was measured in vitro by cell viability assays. We established the neuroendocrine tumor sphere cell line ANI-27S, which displayed stable exponential growth, virtually unlimited expansion in vitro, and expression of stem-cell markers such as CD133, nestin, Sox2, and aldehyde dehydrogenase. FBS-induced differentiation decreased Sox2 and nestin expression. On the basis of real-time PCR, ANI-27S cells expressed the neuroendocrine markers synaptophysin and chromogranin A. Intracranial xenotransplanted brain tumors recapitulated the original patient tumor and temozolomide exhibited cytotoxic effects on tumor sphere cells. For the first time, we demonstrated the presence of a sphere-forming, stem cell-like population in brain metastases from a primary neuroendocrine tumor. We also demonstrated the potential therapeutic effects of temozolomide for this disease.
62 schema:genre research_article
63 schema:inLanguage en
64 schema:isAccessibleForFree false
65 schema:isPartOf N554a2032c6c547bdb27e799b3ee80f74
66 N620aae56175548669594fdeadbed7841
67 sg:journal.1295024
68 schema:name Establishment of a tumor sphere cell line from a metastatic brain neuroendocrine tumor
69 schema:pagination 211-219
70 schema:productId N4f543674e60c412d9959989a77977fd9
71 N712bbcd7273241e490a029ddb3b60115
72 Nb13b29b0ef0b45829263a8f4978cb77e
73 Nce2a10ce25e0467bba626af4544ce21e
74 Neb17a1d94d5540ba8b4524588da69e71
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085426754
76 https://doi.org/10.1007/s00795-017-0160-0
77 schema:sdDatePublished 2019-04-11T10:16
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N16552cd80f2447519208854f61f5bb8b
80 schema:url https://link.springer.com/10.1007%2Fs00795-017-0160-0
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N0076f02f00ff4cd685319a60eabd6e9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Tumor Cells, Cultured
86 rdf:type schema:DefinedTerm
87 N16552cd80f2447519208854f61f5bb8b schema:name Springer Nature - SN SciGraph project
88 rdf:type schema:Organization
89 N19bfb5f3eac443c69521c1e7dad40ef1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Animals
91 rdf:type schema:DefinedTerm
92 N2875e32fe9a74d248e1fc1331bb614fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Brain Neoplasms
94 rdf:type schema:DefinedTerm
95 N2d1bb04f4df845928d1cb0aa06eab0ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Aged
97 rdf:type schema:DefinedTerm
98 N3296403aac13447e90582ff25e0f337e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Mice
100 rdf:type schema:DefinedTerm
101 N43bdaa7cd5434d66b118707f0a361cb3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Neoplasm Transplantation
103 rdf:type schema:DefinedTerm
104 N45e7bc6fa92d489ebec275e315b3d43b rdf:first sg:person.013603420311.27
105 rdf:rest N71c16681c8d64970b1692d6a68d8212d
106 N4a482dc3fad34d3890fd5dc552a3a7ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name AC133 Antigen
108 rdf:type schema:DefinedTerm
109 N4f543674e60c412d9959989a77977fd9 schema:name nlm_unique_id
110 schema:value 101239023
111 rdf:type schema:PropertyValue
112 N507b0ca69fb3488aa80fd693f6177250 rdf:first sg:person.01143402042.32
113 rdf:rest Nc17eab00b3ab4cc38314dfcb7104a434
114 N541a9bc43d2549a08ad36e043e22977f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Aldehyde Dehydrogenase
116 rdf:type schema:DefinedTerm
117 N554a2032c6c547bdb27e799b3ee80f74 schema:volumeNumber 50
118 rdf:type schema:PublicationVolume
119 N55ddd0b534294f8cb136d2fda083eea7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Neuroendocrine Tumors
121 rdf:type schema:DefinedTerm
122 N59315f772ccd4440affd8de702a56bd6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Antineoplastic Agents, Alkylating
124 rdf:type schema:DefinedTerm
125 N59c8df81287c4dad9074ec8fb6d20e32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Temozolomide
127 rdf:type schema:DefinedTerm
128 N602e91c8c0484c19a11492b9b2d7aeeb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Cell Survival
130 rdf:type schema:DefinedTerm
131 N620aae56175548669594fdeadbed7841 schema:issueNumber 4
132 rdf:type schema:PublicationIssue
133 N6941a0f73cc343e69592e928daa06f40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Biomarkers, Tumor
135 rdf:type schema:DefinedTerm
136 N6aa8f6c62ccd444787b976be51fb8a2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name SOXB1 Transcription Factors
138 rdf:type schema:DefinedTerm
139 N6d1a009b13e04ee1a964dddbaf993f92 rdf:first sg:person.01075347562.66
140 rdf:rest N941c1809115e4e1bade4b30dae05d39b
141 N712bbcd7273241e490a029ddb3b60115 schema:name dimensions_id
142 schema:value pub.1085426754
143 rdf:type schema:PropertyValue
144 N7182d1f001cf4079b15a27330f6cfdad rdf:first sg:person.01040370471.34
145 rdf:rest N45e7bc6fa92d489ebec275e315b3d43b
146 N71c16681c8d64970b1692d6a68d8212d rdf:first sg:person.01105254153.88
147 rdf:rest N9c603075603b47229e50fe9e11f0108d
148 N84d2f9bc77e34240902915d1065e26c8 rdf:first sg:person.0637542245.62
149 rdf:rest Nff81b8706b3b43aba2dea164173a8cf6
150 N88b1738be9e2456d9c91addfa3c9b413 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Dacarbazine
152 rdf:type schema:DefinedTerm
153 N8c8c6b7d0ed747aebe6cabcd25048f34 rdf:first sg:person.01130621242.61
154 rdf:rest rdf:nil
155 N8e086d80ab9545238e4d5738bf0f6ad6 rdf:first sg:person.0665013040.71
156 rdf:rest N507b0ca69fb3488aa80fd693f6177250
157 N941c1809115e4e1bade4b30dae05d39b rdf:first sg:person.01266757404.45
158 rdf:rest N84d2f9bc77e34240902915d1065e26c8
159 N9c603075603b47229e50fe9e11f0108d rdf:first sg:person.012445231767.62
160 rdf:rest N8e086d80ab9545238e4d5738bf0f6ad6
161 Nb13b29b0ef0b45829263a8f4978cb77e schema:name readcube_id
162 schema:value b466092415edacb106886fb88814e226725f57e1204d5b8d0308ffe5eb53cca1
163 rdf:type schema:PropertyValue
164 Nb32711a0f55a4d61be165bdd7f85a103 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Synaptophysin
166 rdf:type schema:DefinedTerm
167 Nb3b7180d91f34e92847213eb4d9a2b04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Spheroids, Cellular
169 rdf:type schema:DefinedTerm
170 Nb77a505a04da4540b300b87aaa3eee45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Chromogranin A
172 rdf:type schema:DefinedTerm
173 Nbafc7f7657e94b9fbe87a3b3964eecc2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Nestin
175 rdf:type schema:DefinedTerm
176 Nc17eab00b3ab4cc38314dfcb7104a434 rdf:first sg:person.01003170504.16
177 rdf:rest N6d1a009b13e04ee1a964dddbaf993f92
178 Nc9b35a5b182f45f68b8f7b20049ea2f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Male
180 rdf:type schema:DefinedTerm
181 Nce2a10ce25e0467bba626af4544ce21e schema:name pubmed_id
182 schema:value 28516286
183 rdf:type schema:PropertyValue
184 Ndd04fece523d4efdbba094116fb9a74b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Humans
186 rdf:type schema:DefinedTerm
187 Ne559417ed0a6436ba85532d999c04825 rdf:first sg:person.0751640414.90
188 rdf:rest N8c8c6b7d0ed747aebe6cabcd25048f34
189 Neb17a1d94d5540ba8b4524588da69e71 schema:name doi
190 schema:value 10.1007/s00795-017-0160-0
191 rdf:type schema:PropertyValue
192 Nf3f1fc7dc42f490bbd38544b16875787 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Primary Cell Culture
194 rdf:type schema:DefinedTerm
195 Nf40e957ad3a74023a01a68d513c2acfa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Neoplastic Stem Cells
197 rdf:type schema:DefinedTerm
198 Nff81b8706b3b43aba2dea164173a8cf6 rdf:first sg:person.0662714627.00
199 rdf:rest Ne559417ed0a6436ba85532d999c04825
200 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
201 schema:name Medical and Health Sciences
202 rdf:type schema:DefinedTerm
203 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
204 schema:name Oncology and Carcinogenesis
205 rdf:type schema:DefinedTerm
206 sg:grant.5872848 http://pending.schema.org/fundedItem sg:pub.10.1007/s00795-017-0160-0
207 rdf:type schema:MonetaryGrant
208 sg:grant.5877036 http://pending.schema.org/fundedItem sg:pub.10.1007/s00795-017-0160-0
209 rdf:type schema:MonetaryGrant
210 sg:journal.1295024 schema:issn 1437-773X
211 1860-1480
212 schema:name Medical Molecular Morphology
213 rdf:type schema:Periodical
214 sg:person.01003170504.16 schema:affiliation https://www.grid.ac/institutes/grid.410783.9
215 schema:familyName Oe
216 schema:givenName Souichi
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003170504.16
218 rdf:type schema:Person
219 sg:person.01040370471.34 schema:affiliation https://www.grid.ac/institutes/grid.410783.9
220 schema:familyName Iwata
221 schema:givenName Ryoichi
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040370471.34
223 rdf:type schema:Person
224 sg:person.01075347562.66 schema:affiliation https://www.grid.ac/institutes/grid.410783.9
225 schema:familyName Yoshimura
226 schema:givenName Kunikazu
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075347562.66
228 rdf:type schema:Person
229 sg:person.01105254153.88 schema:affiliation https://www.grid.ac/institutes/grid.410783.9
230 schema:familyName Ito
231 schema:givenName Tomoki
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105254153.88
233 rdf:type schema:Person
234 sg:person.01130621242.61 schema:affiliation https://www.grid.ac/institutes/grid.410783.9
235 schema:familyName Asai
236 schema:givenName Akio
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130621242.61
238 rdf:type schema:Person
239 sg:person.01143402042.32 schema:affiliation https://www.grid.ac/institutes/grid.410783.9
240 schema:familyName Koike
241 schema:givenName Taro
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143402042.32
243 rdf:type schema:Person
244 sg:person.012445231767.62 schema:affiliation https://www.grid.ac/institutes/grid.410783.9
245 schema:familyName Nakano
246 schema:givenName Yosuke
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012445231767.62
248 rdf:type schema:Person
249 sg:person.01266757404.45 schema:affiliation https://www.grid.ac/institutes/grid.410783.9
250 schema:familyName Nonaka
251 schema:givenName Masahiro
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266757404.45
253 rdf:type schema:Person
254 sg:person.013603420311.27 schema:affiliation https://www.grid.ac/institutes/grid.410783.9
255 schema:familyName Maruyama
256 schema:givenName Masato
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013603420311.27
258 rdf:type schema:Person
259 sg:person.0637542245.62 schema:affiliation https://www.grid.ac/institutes/grid.410783.9
260 schema:familyName Nomura
261 schema:givenName Shosaku
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637542245.62
263 rdf:type schema:Person
264 sg:person.0662714627.00 schema:affiliation https://www.grid.ac/institutes/grid.410783.9
265 schema:familyName Sugimoto
266 schema:givenName Tetsuo
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662714627.00
268 rdf:type schema:Person
269 sg:person.0665013040.71 schema:affiliation https://www.grid.ac/institutes/grid.416803.8
270 schema:familyName Kanemura
271 schema:givenName Yonehiro
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665013040.71
273 rdf:type schema:Person
274 sg:person.0751640414.90 schema:affiliation https://www.grid.ac/institutes/grid.410783.9
275 schema:familyName Yamada
276 schema:givenName Hisao
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751640414.90
278 rdf:type schema:Person
279 sg:pub.10.1038/367645a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028822583
280 https://doi.org/10.1038/367645a0
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/bmt.2012.244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028358194
283 https://doi.org/10.1038/bmt.2012.244
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/nmeth758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037605769
286 https://doi.org/10.1038/nmeth758
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/nn.3510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027870553
289 https://doi.org/10.1038/nn.3510
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/sj.bjc.6690325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033288252
292 https://doi.org/10.1038/sj.bjc.6690325
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/sj.cdd.4402283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043286075
295 https://doi.org/10.1038/sj.cdd.4402283
296 rdf:type schema:CreativeWork
297 sg:pub.10.1186/s12967-016-0857-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023235750
298 https://doi.org/10.1186/s12967-016-0857-1
299 rdf:type schema:CreativeWork
300 sg:pub.10.1186/s40001-014-0066-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004430104
301 https://doi.org/10.1186/s40001-014-0066-4
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1002/cncr.11105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046798811
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1002/cncr.20659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032697278
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1002/cncr.24406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024162135
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1002/cncr.29099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001724464
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.ccell.2016.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050525775
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.clineuro.2014.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009935552
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.stem.2007.08.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045510569
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/s1470-2045(07)70410-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003895716
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1053/j.gastro.2011.07.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026830472
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1073/pnas.1600007113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006692555
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1089/scd.2008.0055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059309834
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1097/01.pai.0000210416.53493.0f schema:sameAs https://app.dimensions.ai/details/publication/pub.1033760932
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1126/science.1553558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062490966
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1139/bcb-2012-0100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002570149
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1158/1078-0432.ccr-06-2053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002414313
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1158/1078-0432.ccr-08-1476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002930100
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1159/000333035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041278310
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1200/jco.2005.03.6046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010536433
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1200/jco.2007.11.5964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044289595
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1200/jco.2007.15.4377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037736197
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1200/jco.2011.40.3147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047129062
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1200/jco.2014.60.2532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024132051
346 rdf:type schema:CreativeWork
347 https://doi.org/10.3892/ijo.2012.1592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071512886
348 rdf:type schema:CreativeWork
349 https://doi.org/10.4161/cc.10.9.15486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072296500
350 rdf:type schema:CreativeWork
351 https://www.grid.ac/institutes/grid.410783.9 schema:alternateName Kansai Medical University
352 schema:name Department of Anatomy and Brain Science, Kansai Medical University, Hirakata, Japan
353 Department of Anatomy and Cell Science, Kansai Medical University, Hirakata, Japan
354 Department of Neurosurgery, Kansai Medical University, Hirakata, Japan
355 First Department of Internal Medicine, Kansai Medical University, Hirakata, Japan
356 rdf:type schema:Organization
357 https://www.grid.ac/institutes/grid.416803.8 schema:alternateName Osaka National Hospital
358 schema:name Division of Regenerative Medicine, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, Osaka, Japan
359 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...