Reduced CD8+ T cells infiltration can be associated to a malignant transformation in potentially malignant oral epithelial lesions View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Aline Lauda Freitas Chaves, Ana Gabriela Silva, Flávia Medeiros Maia, Gabriela Francine Martins Lopes, Luiz Fernando Barbosa de Paulo, Luciana Vieira Muniz, Hélio Batista dos Santos, João Marcos Arantes Soares, Alexandre Andrade Souza, Leandro Augusto de Oliveira Barbosa, Adriano Mota Loyola, Eddie Fernando Candido Murta, Márcia Antoniaze Michelin, Rosy Iara Maciel de Azambuja Ribeiro

ABSTRACT

OBJECTIVE: The aim of this study was to evaluate the immunohistochemical expressions of PD1, CD4+, and CD8+ in premalignant lesions (OPML) that were transformed into oral squamous cell carcinoma OSCC (OPML-OSCC), in OSCC and also in premalignant lesions that were not transformed into OSCC (OPML-NOSSC). MATERIALS AND METHODS: Retrospective analyses were performed in order to verify the demographic characteristics of the patients. CD4, CD8, and PD1 IMH studies were carried out on OPML and OSCC samples from 11 patients with OPML-OSCC and OPML, together with samples from 14 patients with OPML-NOSCC. The differences between OPML-OSCC and OPML-NOSCC were analyzed. RESULTS: Non-homogenous leukoplakia, together with the related oral subsite, and the lack of an exposure to tobacco, were all associated with malignant transformations. There were no statistical differences in the PD1 expression and the CD4+ cells in OPML-OSCC and OPML-NOSCC. A significant increment in the CD8+ cells was noted in the OPML that evolved into carcinomas when compared with OPML-NOSCC (p = 0.05), whereas there were higher CD8+ cells levels in the carcinomas when compared with the OPML that evolved into carcinomas (p = 0.027). CONCLUSIONS: CD8+ cells infiltrate more in OPML-NOSCC than in OPML-OSCC. Carcinoma is more infiltrated by CD8+ cells than its associated OPML. CLINICAL RELEVANCE: Understanding immunological factors associated with malignant transformation of oral premalignant lesions can open a new way to treat this disease. More... »

PAGES

1913-1919

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00784-018-2622-8

DOI

http://dx.doi.org/10.1007/s00784-018-2622-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107088916

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30229300


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