Recovery time after oral and maxillofacial ambulatory surgery with dexmedetomidine: an observational study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01

AUTHORS

Belen Hernando, Antonio Martinez-Simon, Elena Cacho-Asenjo, Iñaki F. Troconiz, Cristina Honorato-Cia, Alfredo Panadero, Luis L. Naval, Jorge M. Nuñez-Cordoba

ABSTRACT

OBJECTIVES: To evaluate the relationship between pharmacokinetic descriptors of dexmedetomidine (predicted area under the curve during the procedure, predicted plasma level at the end of the procedure, and duration of procedure) and sedation depth (proportion of time with bispectral index < 85 during the procedure) with recovery time after ambulatory procedures. MATERIALS AND METHODS: Clinical observational study of patients undergoing oral and maxillofacial ambulatory surgery with dexmedetomidine as sole sedative agent. Patients received a loading dose of dexmedetomidine (0.25-1 μg kg-1) followed by a maintenance infusion (0.2-1.4 μg kg-1 h-1) to keep a bispectral index < 85 until 5 min before the end of the procedure, and were transferred to a post-anesthesia care unit until criteria for discharge were met. RESULTS: Data from 75 patients was analyzed. Sedation depth was directly associated with recovery time (Pearson correlation coefficient [r] = 0.26; p = 0.024). Around 7% of the variation in recovery time was explained by the proportion of time with bispectral index < 85. No association with procedure duration (r = 0.01; p = 0.9), predicted area under the curve (r = 0.1; p = 0.4), or predicted plasma level of dexmedetomidine at the end of the procedure (r = 0.12; p = 0.3) with recovery time was observed. CONCLUSIONS: Sedation depth with dexmedetomidine could play a role in increasing recovery time after oral and maxillofacial ambulatory surgery. In our study, the pharmacokinetic descriptors of dexmedetomidine did not seem to influence recovery time. CLINICAL RELEVANCE: Sedation depth with dexmedetomidine could play a role in increasing recovery time after ambulatory procedures. More... »

PAGES

1-7

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Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00784-018-2447-5

DOI

http://dx.doi.org/10.1007/s00784-018-2447-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103485442

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29679228


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    "description": "OBJECTIVES: To evaluate the relationship between pharmacokinetic descriptors of dexmedetomidine (predicted area under the curve during the procedure, predicted plasma level at the end of the procedure, and duration of procedure) and sedation depth (proportion of time with bispectral index <\u200985 during the procedure) with recovery time after ambulatory procedures.\nMATERIALS AND METHODS: Clinical observational study of patients undergoing oral and maxillofacial ambulatory surgery with dexmedetomidine as sole sedative agent. Patients received a loading dose of dexmedetomidine (0.25-1\u00a0\u03bcg\u00a0kg-1) followed by a maintenance infusion (0.2-1.4\u00a0\u03bcg\u00a0kg-1\u00a0h-1) to keep a bispectral index <\u200985 until 5\u00a0min before the end of the procedure, and were transferred to a post-anesthesia care unit until criteria for discharge were met.\nRESULTS: Data from 75 patients was analyzed. Sedation depth was directly associated with recovery time (Pearson correlation coefficient [r]\u2009=\u20090.26; p\u2009=\u20090.024). Around 7% of the variation in recovery time was explained by the proportion of time with bispectral index <\u200985. No association with procedure duration (r\u2009=\u20090.01; p\u2009=\u20090.9), predicted area under the curve (r\u2009=\u20090.1; p\u2009=\u20090.4), or predicted plasma level of dexmedetomidine at the end of the procedure (r\u2009=\u20090.12; p\u2009=\u20090.3) with recovery time was observed.\nCONCLUSIONS: Sedation depth with dexmedetomidine could play a role in increasing recovery time after oral and maxillofacial ambulatory surgery. In our study, the pharmacokinetic descriptors of dexmedetomidine did not seem to influence recovery time.\nCLINICAL RELEVANCE: Sedation depth with dexmedetomidine could play a role in increasing recovery time after ambulatory procedures.", 
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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00784-018-2447-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00784-018-2447-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00784-018-2447-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00784-018-2447-5'


 

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