Experimental variation of the level and the ratio of angiogenic and osteogenic signaling affects the spatiotemporal expression of bone-specific markers ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-09-22

AUTHORS

Norman Moser, Jan Goldstein, Phillip Kauffmann, Matthias Epple, Henning Schliephake

ABSTRACT

ObjectivesThe aim of the present study was to test the hypothesis that the ratio of angiogenic and osteogenic signaling affects ectopic bone formation when delivered in different amounts.Materials and methodsPorous composite PDLLA/CaCO3 scaffolds were loaded with rhBMP2 and rhVEGF in different dosage combinations and implanted into the gluteal muscles of 120 adult male Wistar rats. Bone formation and expression of alkaline phosphatase and Runx2 were quantified by histomorphometry. Spatial distribution across the scaffolds was assessed by using a grid that discriminated between the periphery and center of the scaffolds.ResultsThe evaluation showed that the combined delivery of bone morphogenetic protein BMP2 and VEGF in different dosage combinations did not enhance the overall quantity of ectopic bone formation compared to the delivery of BMP2 alone. The addition of VEGF generally upregulated Runx2 after 4 weeks, which may have retarded terminal osteogenic differentiation. However, slow combined delivery of 1.5–2.0 μg BMP2 combined with 50 ng VEGF165 over a period of 5 weeks supported a more even distribution of bone formation across the implanted scaffolds whereas higher amounts of VEGF did not elicit this effect.ConclusionsThe findings suggest that structural organization rather than the quantity of ectopic bone formation is affected by the dosage and the ratio of BMP2 and VEGF levels at the observed intervals.Clinical relevanceThe development of carriers for dual growth factor delivery has to take into account the necessity to carefully balance the ratio of growth release. More... »

PAGES

1223-1234

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00784-017-2202-3

DOI

http://dx.doi.org/10.1007/s00784-017-2202-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091892891

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28936783


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alkaline Phosphatase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Morphogenetic Protein 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Buttocks", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Core Binding Factor Alpha 1 Subunit", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osteogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Porosity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Wistar", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Scaffolds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transforming Growth Factor beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vascular Endothelial Growth Factor A", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Oral and Maxillofacial Surgery, George Augusta University, Robert-Koch-Str. 40, 37075, G\u00f6ttingen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7450.6", 
          "name": [
            "Department of Oral and Maxillofacial Surgery, George Augusta University, Robert-Koch-Str. 40, 37075, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moser", 
        "givenName": "Norman", 
        "id": "sg:person.01345455432.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345455432.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oral and Maxillofacial Surgery, George Augusta University, Robert-Koch-Str. 40, 37075, G\u00f6ttingen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7450.6", 
          "name": [
            "Department of Oral and Maxillofacial Surgery, George Augusta University, Robert-Koch-Str. 40, 37075, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goldstein", 
        "givenName": "Jan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oral and Maxillofacial Surgery, George Augusta University, Robert-Koch-Str. 40, 37075, G\u00f6ttingen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7450.6", 
          "name": [
            "Department of Oral and Maxillofacial Surgery, George Augusta University, Robert-Koch-Str. 40, 37075, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kauffmann", 
        "givenName": "Phillip", 
        "id": "sg:person.011330373673.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011330373673.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117, Essen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5718.b", 
          "name": [
            "Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Epple", 
        "givenName": "Matthias", 
        "id": "sg:person.011342402346.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011342402346.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oral and Maxillofacial Surgery, George Augusta University, Robert-Koch-Str. 40, 37075, G\u00f6ttingen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7450.6", 
          "name": [
            "Department of Oral and Maxillofacial Surgery, George Augusta University, Robert-Koch-Str. 40, 37075, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schliephake", 
        "givenName": "Henning", 
        "id": "sg:person.01222177644.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222177644.57"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00441-009-0832-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019823184", 
          "https://doi.org/10.1007/s00441-009-0832-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10006-014-0463-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007563721", 
          "https://doi.org/10.1007/s10006-014-0463-4"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-09-22", 
    "datePublishedReg": "2017-09-22", 
    "description": "ObjectivesThe aim of the present study was to test the hypothesis that the ratio of angiogenic and osteogenic signaling affects ectopic bone formation when delivered in different amounts.Materials and methodsPorous composite PDLLA/CaCO3 scaffolds were loaded with rhBMP2 and rhVEGF in different dosage combinations and implanted into the gluteal muscles of 120 adult male Wistar rats. Bone formation and expression of alkaline phosphatase and Runx2 were quantified by histomorphometry. Spatial distribution across the scaffolds was assessed by using a grid that discriminated between the periphery and center of the scaffolds.ResultsThe evaluation showed that the combined delivery of bone morphogenetic protein BMP2 and VEGF in different dosage combinations did not enhance the overall quantity of ectopic bone formation compared to the delivery of BMP2 alone. The addition of VEGF generally upregulated Runx2 after 4\u00a0weeks, which may have retarded terminal osteogenic differentiation. However, slow combined delivery of 1.5\u20132.0\u00a0\u03bcg BMP2 combined with 50\u00a0ng VEGF165 over a period of 5\u00a0weeks supported a more even distribution of bone formation across the implanted scaffolds whereas higher amounts of VEGF did not elicit this effect.ConclusionsThe findings suggest that structural organization rather than the quantity of ectopic bone formation is affected by the dosage and the ratio of BMP2 and VEGF levels at the observed intervals.Clinical relevanceThe development of carriers for dual growth factor delivery has to take into account the necessity to carefully balance the ratio of growth release.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00784-017-2202-3", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.8040592", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1116831", 
        "issn": [
          "1432-6981", 
          "1436-3771"
        ], 
        "name": "Clinical Oral Investigations", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "22"
      }
    ], 
    "keywords": [
      "dual growth factor delivery", 
      "CaCO3 scaffolds", 
      "delivery of BMP2", 
      "growth factor delivery", 
      "different dosage combinations", 
      "ectopic bone formation", 
      "bone formation", 
      "adult male Wistar rats", 
      "factor delivery", 
      "male Wistar rats", 
      "dosage combinations", 
      "osteogenic signaling", 
      "different amounts", 
      "scaffolds", 
      "terminal osteogenic differentiation", 
      "VEGF levels", 
      "Wistar rats", 
      "ObjectivesThe aim", 
      "gluteal muscles", 
      "bone-specific markers", 
      "upregulated Runx2", 
      "addition of VEGF", 
      "spatial distribution", 
      "ConclusionsThe findings", 
      "even distribution", 
      "grid", 
      "VEGF", 
      "Combined delivery", 
      "ectopic sites", 
      "ratio", 
      "osteogenic differentiation", 
      "alkaline phosphatase", 
      "weeks", 
      "present study", 
      "ResultsThe evaluation", 
      "bone morphogenetic proteins BMP2", 
      "materials", 
      "delivery", 
      "high amounts", 
      "formation", 
      "experimental variation", 
      "BMP2", 
      "spatiotemporal expression", 
      "overall quantity", 
      "quantity", 
      "Runx2", 
      "distribution", 
      "signaling", 
      "amount", 
      "expression", 
      "rats", 
      "histomorphometry", 
      "muscle", 
      "rhBMP2", 
      "carriers", 
      "combination", 
      "levels", 
      "rhVEGF", 
      "VEGF165", 
      "markers", 
      "dosage", 
      "aim", 
      "findings", 
      "account", 
      "variation", 
      "release", 
      "differentiation", 
      "interval", 
      "phosphatase", 
      "period", 
      "addition", 
      "effect", 
      "evaluation", 
      "center", 
      "study", 
      "observed intervals", 
      "periphery", 
      "hypothesis", 
      "necessity", 
      "development", 
      "sites", 
      "structural organization", 
      "organization", 
      "growth releases"
    ], 
    "name": "Experimental variation of the level and the ratio of angiogenic and osteogenic signaling affects the spatiotemporal expression of bone-specific markers and organization of bone formation in ectopic sites", 
    "pagination": "1223-1234", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1091892891"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00784-017-2202-3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28936783"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00784-017-2202-3", 
      "https://app.dimensions.ai/details/publication/pub.1091892891"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:43", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_742.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00784-017-2202-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00784-017-2202-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00784-017-2202-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00784-017-2202-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00784-017-2202-3'


 

This table displays all metadata directly associated to this object as RDF triples.

241 TRIPLES      21 PREDICATES      125 URIs      115 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00784-017-2202-3 schema:about N1aaca70695094961b8fcbdbe08a09419
2 N1c2b3f8ec1734f07b83cd3600e9447db
3 N2f73bee9948549eea1ef7778a48eb94e
4 N60061b2abe6f4b59847aff9cc41288ff
5 N73a308eaa4394ac68840b6faa7789e68
6 N889caa939a284d96ac199bb77204bd3e
7 N8e42c4ec3a6f4423a0211e410fd58b18
8 Na647869a9d03494095e7bdf56edd6aad
9 Naccc7ec77e17443294fa7344ab2973d0
10 Nd19029fb581e45788d749f532a013145
11 Ne16f84e367534012a7df9bad3778724c
12 Nf2d3cab63eee4cfd99e7e5a62d2a2b7b
13 Nf5fb6e3b36d24efeae481c795cb3ad5e
14 Nfc4b93a8e95b4b548c60dbc5ff859137
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author Nda502dec2a3242429a21987bda0b9ae2
18 schema:citation sg:pub.10.1007/s00441-009-0832-8
19 sg:pub.10.1007/s10006-014-0463-4
20 schema:datePublished 2017-09-22
21 schema:datePublishedReg 2017-09-22
22 schema:description ObjectivesThe aim of the present study was to test the hypothesis that the ratio of angiogenic and osteogenic signaling affects ectopic bone formation when delivered in different amounts.Materials and methodsPorous composite PDLLA/CaCO3 scaffolds were loaded with rhBMP2 and rhVEGF in different dosage combinations and implanted into the gluteal muscles of 120 adult male Wistar rats. Bone formation and expression of alkaline phosphatase and Runx2 were quantified by histomorphometry. Spatial distribution across the scaffolds was assessed by using a grid that discriminated between the periphery and center of the scaffolds.ResultsThe evaluation showed that the combined delivery of bone morphogenetic protein BMP2 and VEGF in different dosage combinations did not enhance the overall quantity of ectopic bone formation compared to the delivery of BMP2 alone. The addition of VEGF generally upregulated Runx2 after 4 weeks, which may have retarded terminal osteogenic differentiation. However, slow combined delivery of 1.5–2.0 μg BMP2 combined with 50 ng VEGF165 over a period of 5 weeks supported a more even distribution of bone formation across the implanted scaffolds whereas higher amounts of VEGF did not elicit this effect.ConclusionsThe findings suggest that structural organization rather than the quantity of ectopic bone formation is affected by the dosage and the ratio of BMP2 and VEGF levels at the observed intervals.Clinical relevanceThe development of carriers for dual growth factor delivery has to take into account the necessity to carefully balance the ratio of growth release.
23 schema:genre article
24 schema:isAccessibleForFree false
25 schema:isPartOf N487187a8970b4824aaaa0981cf253475
26 Ne7f7b03ce329469b9b80e24c9b56fb64
27 sg:journal.1116831
28 schema:keywords BMP2
29 CaCO3 scaffolds
30 Combined delivery
31 ConclusionsThe findings
32 ObjectivesThe aim
33 ResultsThe evaluation
34 Runx2
35 VEGF
36 VEGF levels
37 VEGF165
38 Wistar rats
39 account
40 addition
41 addition of VEGF
42 adult male Wistar rats
43 aim
44 alkaline phosphatase
45 amount
46 bone formation
47 bone morphogenetic proteins BMP2
48 bone-specific markers
49 carriers
50 center
51 combination
52 delivery
53 delivery of BMP2
54 development
55 different amounts
56 different dosage combinations
57 differentiation
58 distribution
59 dosage
60 dosage combinations
61 dual growth factor delivery
62 ectopic bone formation
63 ectopic sites
64 effect
65 evaluation
66 even distribution
67 experimental variation
68 expression
69 factor delivery
70 findings
71 formation
72 gluteal muscles
73 grid
74 growth factor delivery
75 growth releases
76 high amounts
77 histomorphometry
78 hypothesis
79 interval
80 levels
81 male Wistar rats
82 markers
83 materials
84 muscle
85 necessity
86 observed intervals
87 organization
88 osteogenic differentiation
89 osteogenic signaling
90 overall quantity
91 period
92 periphery
93 phosphatase
94 present study
95 quantity
96 ratio
97 rats
98 release
99 rhBMP2
100 rhVEGF
101 scaffolds
102 signaling
103 sites
104 spatial distribution
105 spatiotemporal expression
106 structural organization
107 study
108 terminal osteogenic differentiation
109 upregulated Runx2
110 variation
111 weeks
112 schema:name Experimental variation of the level and the ratio of angiogenic and osteogenic signaling affects the spatiotemporal expression of bone-specific markers and organization of bone formation in ectopic sites
113 schema:pagination 1223-1234
114 schema:productId N1333ad01680f49039221037ff651da77
115 N80fda44d70dc4c22a7d792a40b7abbb3
116 N87d014e6ed514567ac2717c5b95c60b8
117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091892891
118 https://doi.org/10.1007/s00784-017-2202-3
119 schema:sdDatePublished 2022-10-01T06:43
120 schema:sdLicense https://scigraph.springernature.com/explorer/license/
121 schema:sdPublisher N4d8ff54474e642bcaa78f5560d3d742d
122 schema:url https://doi.org/10.1007/s00784-017-2202-3
123 sgo:license sg:explorer/license/
124 sgo:sdDataset articles
125 rdf:type schema:ScholarlyArticle
126 N00ec9bfcbae641189f6430b2ab2b72c2 rdf:first Nf2612b63bf864c89a0f6ef592699e72c
127 rdf:rest N7a9a2f9e552443a79f6351da4f5cbe3d
128 N1333ad01680f49039221037ff651da77 schema:name doi
129 schema:value 10.1007/s00784-017-2202-3
130 rdf:type schema:PropertyValue
131 N1aaca70695094961b8fcbdbe08a09419 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Recombinant Proteins
133 rdf:type schema:DefinedTerm
134 N1c2b3f8ec1734f07b83cd3600e9447db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Transforming Growth Factor beta
136 rdf:type schema:DefinedTerm
137 N2f73bee9948549eea1ef7778a48eb94e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Vascular Endothelial Growth Factor A
139 rdf:type schema:DefinedTerm
140 N487187a8970b4824aaaa0981cf253475 schema:volumeNumber 22
141 rdf:type schema:PublicationVolume
142 N4d8ff54474e642bcaa78f5560d3d742d schema:name Springer Nature - SN SciGraph project
143 rdf:type schema:Organization
144 N60061b2abe6f4b59847aff9cc41288ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Rats
146 rdf:type schema:DefinedTerm
147 N73a308eaa4394ac68840b6faa7789e68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Alkaline Phosphatase
149 rdf:type schema:DefinedTerm
150 N7a9a2f9e552443a79f6351da4f5cbe3d rdf:first sg:person.011330373673.78
151 rdf:rest Ne48d5e5c5dcf4945ac518bd5f057aedf
152 N80fda44d70dc4c22a7d792a40b7abbb3 schema:name dimensions_id
153 schema:value pub.1091892891
154 rdf:type schema:PropertyValue
155 N87d014e6ed514567ac2717c5b95c60b8 schema:name pubmed_id
156 schema:value 28936783
157 rdf:type schema:PropertyValue
158 N889caa939a284d96ac199bb77204bd3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Core Binding Factor Alpha 1 Subunit
160 rdf:type schema:DefinedTerm
161 N8e42c4ec3a6f4423a0211e410fd58b18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Male
163 rdf:type schema:DefinedTerm
164 N9e2e1c6dac7940748707f14c48420883 rdf:first sg:person.01222177644.57
165 rdf:rest rdf:nil
166 Na647869a9d03494095e7bdf56edd6aad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Bone Morphogenetic Protein 2
168 rdf:type schema:DefinedTerm
169 Naccc7ec77e17443294fa7344ab2973d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Buttocks
171 rdf:type schema:DefinedTerm
172 Nd19029fb581e45788d749f532a013145 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Rats, Wistar
174 rdf:type schema:DefinedTerm
175 Nda502dec2a3242429a21987bda0b9ae2 rdf:first sg:person.01345455432.60
176 rdf:rest N00ec9bfcbae641189f6430b2ab2b72c2
177 Ne16f84e367534012a7df9bad3778724c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Osteogenesis
179 rdf:type schema:DefinedTerm
180 Ne48d5e5c5dcf4945ac518bd5f057aedf rdf:first sg:person.011342402346.80
181 rdf:rest N9e2e1c6dac7940748707f14c48420883
182 Ne7f7b03ce329469b9b80e24c9b56fb64 schema:issueNumber 3
183 rdf:type schema:PublicationIssue
184 Nf2612b63bf864c89a0f6ef592699e72c schema:affiliation grid-institutes:grid.7450.6
185 schema:familyName Goldstein
186 schema:givenName Jan
187 rdf:type schema:Person
188 Nf2d3cab63eee4cfd99e7e5a62d2a2b7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Animals
190 rdf:type schema:DefinedTerm
191 Nf5fb6e3b36d24efeae481c795cb3ad5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Tissue Scaffolds
193 rdf:type schema:DefinedTerm
194 Nfc4b93a8e95b4b548c60dbc5ff859137 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Porosity
196 rdf:type schema:DefinedTerm
197 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
198 schema:name Medical and Health Sciences
199 rdf:type schema:DefinedTerm
200 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
201 schema:name Clinical Sciences
202 rdf:type schema:DefinedTerm
203 sg:grant.8040592 http://pending.schema.org/fundedItem sg:pub.10.1007/s00784-017-2202-3
204 rdf:type schema:MonetaryGrant
205 sg:journal.1116831 schema:issn 1432-6981
206 1436-3771
207 schema:name Clinical Oral Investigations
208 schema:publisher Springer Nature
209 rdf:type schema:Periodical
210 sg:person.011330373673.78 schema:affiliation grid-institutes:grid.7450.6
211 schema:familyName Kauffmann
212 schema:givenName Phillip
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011330373673.78
214 rdf:type schema:Person
215 sg:person.011342402346.80 schema:affiliation grid-institutes:grid.5718.b
216 schema:familyName Epple
217 schema:givenName Matthias
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011342402346.80
219 rdf:type schema:Person
220 sg:person.01222177644.57 schema:affiliation grid-institutes:grid.7450.6
221 schema:familyName Schliephake
222 schema:givenName Henning
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222177644.57
224 rdf:type schema:Person
225 sg:person.01345455432.60 schema:affiliation grid-institutes:grid.7450.6
226 schema:familyName Moser
227 schema:givenName Norman
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345455432.60
229 rdf:type schema:Person
230 sg:pub.10.1007/s00441-009-0832-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019823184
231 https://doi.org/10.1007/s00441-009-0832-8
232 rdf:type schema:CreativeWork
233 sg:pub.10.1007/s10006-014-0463-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007563721
234 https://doi.org/10.1007/s10006-014-0463-4
235 rdf:type schema:CreativeWork
236 grid-institutes:grid.5718.b schema:alternateName Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117, Essen, Germany
237 schema:name Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117, Essen, Germany
238 rdf:type schema:Organization
239 grid-institutes:grid.7450.6 schema:alternateName Department of Oral and Maxillofacial Surgery, George Augusta University, Robert-Koch-Str. 40, 37075, Göttingen, Germany
240 schema:name Department of Oral and Maxillofacial Surgery, George Augusta University, Robert-Koch-Str. 40, 37075, Göttingen, Germany
241 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...