Experimental variation of the level and the ratio of angiogenic and osteogenic signaling affects the spatiotemporal expression of bone-specific markers ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-09-22

AUTHORS

Norman Moser, Jan Goldstein, Phillip Kauffmann, Matthias Epple, Henning Schliephake

ABSTRACT

ObjectivesThe aim of the present study was to test the hypothesis that the ratio of angiogenic and osteogenic signaling affects ectopic bone formation when delivered in different amounts.Materials and methodsPorous composite PDLLA/CaCO3 scaffolds were loaded with rhBMP2 and rhVEGF in different dosage combinations and implanted into the gluteal muscles of 120 adult male Wistar rats. Bone formation and expression of alkaline phosphatase and Runx2 were quantified by histomorphometry. Spatial distribution across the scaffolds was assessed by using a grid that discriminated between the periphery and center of the scaffolds.ResultsThe evaluation showed that the combined delivery of bone morphogenetic protein BMP2 and VEGF in different dosage combinations did not enhance the overall quantity of ectopic bone formation compared to the delivery of BMP2 alone. The addition of VEGF generally upregulated Runx2 after 4 weeks, which may have retarded terminal osteogenic differentiation. However, slow combined delivery of 1.5–2.0 μg BMP2 combined with 50 ng VEGF165 over a period of 5 weeks supported a more even distribution of bone formation across the implanted scaffolds whereas higher amounts of VEGF did not elicit this effect.ConclusionsThe findings suggest that structural organization rather than the quantity of ectopic bone formation is affected by the dosage and the ratio of BMP2 and VEGF levels at the observed intervals.Clinical relevanceThe development of carriers for dual growth factor delivery has to take into account the necessity to carefully balance the ratio of growth release. More... »

PAGES

1223-1234

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00784-017-2202-3

DOI

http://dx.doi.org/10.1007/s00784-017-2202-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091892891

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28936783


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alkaline Phosphatase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Morphogenetic Protein 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Buttocks", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Core Binding Factor Alpha 1 Subunit", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osteogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Porosity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Wistar", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Scaffolds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transforming Growth Factor beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vascular Endothelial Growth Factor A", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Oral and Maxillofacial Surgery, George Augusta University, Robert-Koch-Str. 40, 37075, G\u00f6ttingen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7450.6", 
          "name": [
            "Department of Oral and Maxillofacial Surgery, George Augusta University, Robert-Koch-Str. 40, 37075, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moser", 
        "givenName": "Norman", 
        "id": "sg:person.01345455432.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345455432.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oral and Maxillofacial Surgery, George Augusta University, Robert-Koch-Str. 40, 37075, G\u00f6ttingen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7450.6", 
          "name": [
            "Department of Oral and Maxillofacial Surgery, George Augusta University, Robert-Koch-Str. 40, 37075, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goldstein", 
        "givenName": "Jan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oral and Maxillofacial Surgery, George Augusta University, Robert-Koch-Str. 40, 37075, G\u00f6ttingen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7450.6", 
          "name": [
            "Department of Oral and Maxillofacial Surgery, George Augusta University, Robert-Koch-Str. 40, 37075, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kauffmann", 
        "givenName": "Phillip", 
        "id": "sg:person.011330373673.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011330373673.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117, Essen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5718.b", 
          "name": [
            "Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Epple", 
        "givenName": "Matthias", 
        "id": "sg:person.011342402346.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011342402346.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oral and Maxillofacial Surgery, George Augusta University, Robert-Koch-Str. 40, 37075, G\u00f6ttingen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7450.6", 
          "name": [
            "Department of Oral and Maxillofacial Surgery, George Augusta University, Robert-Koch-Str. 40, 37075, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schliephake", 
        "givenName": "Henning", 
        "id": "sg:person.01222177644.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222177644.57"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00441-009-0832-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019823184", 
          "https://doi.org/10.1007/s00441-009-0832-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10006-014-0463-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007563721", 
          "https://doi.org/10.1007/s10006-014-0463-4"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-09-22", 
    "datePublishedReg": "2017-09-22", 
    "description": "ObjectivesThe aim of the present study was to test the hypothesis that the ratio of angiogenic and osteogenic signaling affects ectopic bone formation when delivered in different amounts.Materials and methodsPorous composite PDLLA/CaCO3 scaffolds were loaded with rhBMP2 and rhVEGF in different dosage combinations and implanted into the gluteal muscles of 120 adult male Wistar rats. Bone formation and expression of alkaline phosphatase and Runx2 were quantified by histomorphometry. Spatial distribution across the scaffolds was assessed by using a grid that discriminated between the periphery and center of the scaffolds.ResultsThe evaluation showed that the combined delivery of bone morphogenetic protein BMP2 and VEGF in different dosage combinations did not enhance the overall quantity of ectopic bone formation compared to the delivery of BMP2 alone. The addition of VEGF generally upregulated Runx2 after 4\u00a0weeks, which may have retarded terminal osteogenic differentiation. However, slow combined delivery of 1.5\u20132.0\u00a0\u03bcg BMP2 combined with 50\u00a0ng VEGF165 over a period of 5\u00a0weeks supported a more even distribution of bone formation across the implanted scaffolds whereas higher amounts of VEGF did not elicit this effect.ConclusionsThe findings suggest that structural organization rather than the quantity of ectopic bone formation is affected by the dosage and the ratio of BMP2 and VEGF levels at the observed intervals.Clinical relevanceThe development of carriers for dual growth factor delivery has to take into account the necessity to carefully balance the ratio of growth release.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00784-017-2202-3", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.8040592", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1116831", 
        "issn": [
          "1432-6981", 
          "1436-3771"
        ], 
        "name": "Clinical Oral Investigations", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "22"
      }
    ], 
    "keywords": [
      "dual growth factor delivery", 
      "CaCO3 scaffolds", 
      "delivery of BMP2", 
      "growth factor delivery", 
      "different dosage combinations", 
      "ectopic bone formation", 
      "bone formation", 
      "adult male Wistar rats", 
      "factor delivery", 
      "male Wistar rats", 
      "dosage combinations", 
      "osteogenic signaling", 
      "different amounts", 
      "scaffolds", 
      "terminal osteogenic differentiation", 
      "VEGF levels", 
      "Wistar rats", 
      "ObjectivesThe aim", 
      "gluteal muscles", 
      "bone-specific markers", 
      "upregulated Runx2", 
      "addition of VEGF", 
      "spatial distribution", 
      "ConclusionsThe findings", 
      "even distribution", 
      "grid", 
      "VEGF", 
      "Combined delivery", 
      "ectopic sites", 
      "ratio", 
      "osteogenic differentiation", 
      "alkaline phosphatase", 
      "weeks", 
      "present study", 
      "ResultsThe evaluation", 
      "bone morphogenetic proteins BMP2", 
      "materials", 
      "delivery", 
      "high amounts", 
      "formation", 
      "experimental variation", 
      "BMP2", 
      "spatiotemporal expression", 
      "overall quantity", 
      "quantity", 
      "Runx2", 
      "distribution", 
      "signaling", 
      "amount", 
      "expression", 
      "rats", 
      "histomorphometry", 
      "muscle", 
      "rhBMP2", 
      "carriers", 
      "combination", 
      "levels", 
      "rhVEGF", 
      "VEGF165", 
      "markers", 
      "dosage", 
      "aim", 
      "findings", 
      "account", 
      "variation", 
      "release", 
      "differentiation", 
      "interval", 
      "phosphatase", 
      "period", 
      "addition", 
      "effect", 
      "evaluation", 
      "center", 
      "study", 
      "observed intervals", 
      "periphery", 
      "hypothesis", 
      "necessity", 
      "development", 
      "sites", 
      "structural organization", 
      "organization", 
      "growth releases"
    ], 
    "name": "Experimental variation of the level and the ratio of angiogenic and osteogenic signaling affects the spatiotemporal expression of bone-specific markers and organization of bone formation in ectopic sites", 
    "pagination": "1223-1234", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1091892891"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00784-017-2202-3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28936783"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00784-017-2202-3", 
      "https://app.dimensions.ai/details/publication/pub.1091892891"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:37", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_752.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00784-017-2202-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00784-017-2202-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00784-017-2202-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00784-017-2202-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00784-017-2202-3'


 

This table displays all metadata directly associated to this object as RDF triples.

241 TRIPLES      21 PREDICATES      125 URIs      115 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00784-017-2202-3 schema:about N0cc5b797f35a411190b0e481df85d8e2
2 N110c2a9dc5f246fdb07d5f788a29cebe
3 N14ebd5d777b1405ab89b175d46007132
4 N16392e0dc88542b7a44d51cd3680ac7c
5 N2086e5f5b947414f8f31d78917203deb
6 N4b85275b926f49cfbfe80123a627844c
7 N4c57168fb3a54a18b76a5a551186d509
8 N4cb658426afe49b49f36f06223f30532
9 Nbe6177a5435f4125aa254ee3c4bbd3ca
10 Nc363803c18ac43149a2410bf65226974
11 Nc804bc53303b452cbb84232469baffee
12 Nccd45430aee540efabdbc497cac36b76
13 Ne87ffd11e0fd4fbcb1531337367f97ca
14 Nf3fc4d475a7a4eb68ad0cbe9660d7d2c
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author Nb296d2e1e17a4385a6e83100ad0cdba4
18 schema:citation sg:pub.10.1007/s00441-009-0832-8
19 sg:pub.10.1007/s10006-014-0463-4
20 schema:datePublished 2017-09-22
21 schema:datePublishedReg 2017-09-22
22 schema:description ObjectivesThe aim of the present study was to test the hypothesis that the ratio of angiogenic and osteogenic signaling affects ectopic bone formation when delivered in different amounts.Materials and methodsPorous composite PDLLA/CaCO3 scaffolds were loaded with rhBMP2 and rhVEGF in different dosage combinations and implanted into the gluteal muscles of 120 adult male Wistar rats. Bone formation and expression of alkaline phosphatase and Runx2 were quantified by histomorphometry. Spatial distribution across the scaffolds was assessed by using a grid that discriminated between the periphery and center of the scaffolds.ResultsThe evaluation showed that the combined delivery of bone morphogenetic protein BMP2 and VEGF in different dosage combinations did not enhance the overall quantity of ectopic bone formation compared to the delivery of BMP2 alone. The addition of VEGF generally upregulated Runx2 after 4 weeks, which may have retarded terminal osteogenic differentiation. However, slow combined delivery of 1.5–2.0 μg BMP2 combined with 50 ng VEGF165 over a period of 5 weeks supported a more even distribution of bone formation across the implanted scaffolds whereas higher amounts of VEGF did not elicit this effect.ConclusionsThe findings suggest that structural organization rather than the quantity of ectopic bone formation is affected by the dosage and the ratio of BMP2 and VEGF levels at the observed intervals.Clinical relevanceThe development of carriers for dual growth factor delivery has to take into account the necessity to carefully balance the ratio of growth release.
23 schema:genre article
24 schema:isAccessibleForFree false
25 schema:isPartOf N2cad60780fae4f36b42394f1140d3f8c
26 Nd4ed9d7bb1f84a38bedbba617c60a924
27 sg:journal.1116831
28 schema:keywords BMP2
29 CaCO3 scaffolds
30 Combined delivery
31 ConclusionsThe findings
32 ObjectivesThe aim
33 ResultsThe evaluation
34 Runx2
35 VEGF
36 VEGF levels
37 VEGF165
38 Wistar rats
39 account
40 addition
41 addition of VEGF
42 adult male Wistar rats
43 aim
44 alkaline phosphatase
45 amount
46 bone formation
47 bone morphogenetic proteins BMP2
48 bone-specific markers
49 carriers
50 center
51 combination
52 delivery
53 delivery of BMP2
54 development
55 different amounts
56 different dosage combinations
57 differentiation
58 distribution
59 dosage
60 dosage combinations
61 dual growth factor delivery
62 ectopic bone formation
63 ectopic sites
64 effect
65 evaluation
66 even distribution
67 experimental variation
68 expression
69 factor delivery
70 findings
71 formation
72 gluteal muscles
73 grid
74 growth factor delivery
75 growth releases
76 high amounts
77 histomorphometry
78 hypothesis
79 interval
80 levels
81 male Wistar rats
82 markers
83 materials
84 muscle
85 necessity
86 observed intervals
87 organization
88 osteogenic differentiation
89 osteogenic signaling
90 overall quantity
91 period
92 periphery
93 phosphatase
94 present study
95 quantity
96 ratio
97 rats
98 release
99 rhBMP2
100 rhVEGF
101 scaffolds
102 signaling
103 sites
104 spatial distribution
105 spatiotemporal expression
106 structural organization
107 study
108 terminal osteogenic differentiation
109 upregulated Runx2
110 variation
111 weeks
112 schema:name Experimental variation of the level and the ratio of angiogenic and osteogenic signaling affects the spatiotemporal expression of bone-specific markers and organization of bone formation in ectopic sites
113 schema:pagination 1223-1234
114 schema:productId N394ae4af14744411830e6c1867f26cc9
115 Naa58483e96444aaba78cda98d2db2642
116 Nbb174a0eafed486eb62d35047bea50e1
117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091892891
118 https://doi.org/10.1007/s00784-017-2202-3
119 schema:sdDatePublished 2022-12-01T06:37
120 schema:sdLicense https://scigraph.springernature.com/explorer/license/
121 schema:sdPublisher Nd1be4332602540c6b4feafb731c31ecc
122 schema:url https://doi.org/10.1007/s00784-017-2202-3
123 sgo:license sg:explorer/license/
124 sgo:sdDataset articles
125 rdf:type schema:ScholarlyArticle
126 N0cc5b797f35a411190b0e481df85d8e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Animals
128 rdf:type schema:DefinedTerm
129 N110c2a9dc5f246fdb07d5f788a29cebe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Buttocks
131 rdf:type schema:DefinedTerm
132 N14ebd5d777b1405ab89b175d46007132 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Recombinant Proteins
134 rdf:type schema:DefinedTerm
135 N15d666c93c544583b01a1961399e0ff4 rdf:first sg:person.01222177644.57
136 rdf:rest rdf:nil
137 N16392e0dc88542b7a44d51cd3680ac7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Rats
139 rdf:type schema:DefinedTerm
140 N2086e5f5b947414f8f31d78917203deb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Male
142 rdf:type schema:DefinedTerm
143 N2cad60780fae4f36b42394f1140d3f8c schema:volumeNumber 22
144 rdf:type schema:PublicationVolume
145 N394ae4af14744411830e6c1867f26cc9 schema:name pubmed_id
146 schema:value 28936783
147 rdf:type schema:PropertyValue
148 N4b85275b926f49cfbfe80123a627844c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Porosity
150 rdf:type schema:DefinedTerm
151 N4c57168fb3a54a18b76a5a551186d509 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Tissue Scaffolds
153 rdf:type schema:DefinedTerm
154 N4cb658426afe49b49f36f06223f30532 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Bone Morphogenetic Protein 2
156 rdf:type schema:DefinedTerm
157 N7874d4ea12414871aab383afa88a1d84 rdf:first sg:person.011342402346.80
158 rdf:rest N15d666c93c544583b01a1961399e0ff4
159 Naa58483e96444aaba78cda98d2db2642 schema:name dimensions_id
160 schema:value pub.1091892891
161 rdf:type schema:PropertyValue
162 Nb296d2e1e17a4385a6e83100ad0cdba4 rdf:first sg:person.01345455432.60
163 rdf:rest Nf62b942ca35440818fdba72e3c15e340
164 Nbb174a0eafed486eb62d35047bea50e1 schema:name doi
165 schema:value 10.1007/s00784-017-2202-3
166 rdf:type schema:PropertyValue
167 Nbb987889a0504c1ebd31cbfe5890799d rdf:first sg:person.011330373673.78
168 rdf:rest N7874d4ea12414871aab383afa88a1d84
169 Nbe6177a5435f4125aa254ee3c4bbd3ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Osteogenesis
171 rdf:type schema:DefinedTerm
172 Nc363803c18ac43149a2410bf65226974 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Vascular Endothelial Growth Factor A
174 rdf:type schema:DefinedTerm
175 Nc804bc53303b452cbb84232469baffee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Rats, Wistar
177 rdf:type schema:DefinedTerm
178 Nccd45430aee540efabdbc497cac36b76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Transforming Growth Factor beta
180 rdf:type schema:DefinedTerm
181 Nd1be4332602540c6b4feafb731c31ecc schema:name Springer Nature - SN SciGraph project
182 rdf:type schema:Organization
183 Nd4ed9d7bb1f84a38bedbba617c60a924 schema:issueNumber 3
184 rdf:type schema:PublicationIssue
185 Ndeb5d59f200842f5a054b947a7669eef schema:affiliation grid-institutes:grid.7450.6
186 schema:familyName Goldstein
187 schema:givenName Jan
188 rdf:type schema:Person
189 Ne87ffd11e0fd4fbcb1531337367f97ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Core Binding Factor Alpha 1 Subunit
191 rdf:type schema:DefinedTerm
192 Nf3fc4d475a7a4eb68ad0cbe9660d7d2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Alkaline Phosphatase
194 rdf:type schema:DefinedTerm
195 Nf62b942ca35440818fdba72e3c15e340 rdf:first Ndeb5d59f200842f5a054b947a7669eef
196 rdf:rest Nbb987889a0504c1ebd31cbfe5890799d
197 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
198 schema:name Medical and Health Sciences
199 rdf:type schema:DefinedTerm
200 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
201 schema:name Clinical Sciences
202 rdf:type schema:DefinedTerm
203 sg:grant.8040592 http://pending.schema.org/fundedItem sg:pub.10.1007/s00784-017-2202-3
204 rdf:type schema:MonetaryGrant
205 sg:journal.1116831 schema:issn 1432-6981
206 1436-3771
207 schema:name Clinical Oral Investigations
208 schema:publisher Springer Nature
209 rdf:type schema:Periodical
210 sg:person.011330373673.78 schema:affiliation grid-institutes:grid.7450.6
211 schema:familyName Kauffmann
212 schema:givenName Phillip
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011330373673.78
214 rdf:type schema:Person
215 sg:person.011342402346.80 schema:affiliation grid-institutes:grid.5718.b
216 schema:familyName Epple
217 schema:givenName Matthias
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011342402346.80
219 rdf:type schema:Person
220 sg:person.01222177644.57 schema:affiliation grid-institutes:grid.7450.6
221 schema:familyName Schliephake
222 schema:givenName Henning
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222177644.57
224 rdf:type schema:Person
225 sg:person.01345455432.60 schema:affiliation grid-institutes:grid.7450.6
226 schema:familyName Moser
227 schema:givenName Norman
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345455432.60
229 rdf:type schema:Person
230 sg:pub.10.1007/s00441-009-0832-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019823184
231 https://doi.org/10.1007/s00441-009-0832-8
232 rdf:type schema:CreativeWork
233 sg:pub.10.1007/s10006-014-0463-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007563721
234 https://doi.org/10.1007/s10006-014-0463-4
235 rdf:type schema:CreativeWork
236 grid-institutes:grid.5718.b schema:alternateName Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117, Essen, Germany
237 schema:name Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117, Essen, Germany
238 rdf:type schema:Organization
239 grid-institutes:grid.7450.6 schema:alternateName Department of Oral and Maxillofacial Surgery, George Augusta University, Robert-Koch-Str. 40, 37075, Göttingen, Germany
240 schema:name Department of Oral and Maxillofacial Surgery, George Augusta University, Robert-Koch-Str. 40, 37075, Göttingen, Germany
241 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...