No association of oral lichen planus and hepatitis C virus infection in central Germany View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-09-28

AUTHORS

Torsten W. Remmerbach, Jan Liese, Sarah Krause, Ingolf Schiefke, Franziska Schiefke, Melanie Maier, Uwe G. Liebert

ABSTRACT

ObjectivesCo-occurrence of oral lichen planus (OLP) and chronic hepatitis C virus (HCV) infection suggests a strong association, but the relation between mucocutaneus, autoimmune lichen planus and HCV infection remains unclear. In areas with higher prevalence of HCV infection in general population, like Japan and southern Europe, 20 to 40 % of patients with OLP test positive for anti-HCV antibodies, whereas in German populations, a co-occurrence of 4.2 to 16 % was reported.Material and methodsWe screened 143 patients with histopathologically proven OLP for prevalence of anti-HCV antibodies. Additionally, we examined 51 anti-HCV-positive subjects with current or past HCV infection for clinical symptoms of OLP. In all patients, confirmatory diagnosis was made by the detection of HCV RNA via reverse transcription-polymerase chain reaction (RT-PCR). A randomized control group comprised 109 blood sera samples of patients without any characteristics of OLP.ResultsThe results of all patients showed no co-occurrence in either cohort.ConclusionIn conclusion, no association between oral lichen planus and chronic HCV infection in our study population was found.Clinical relevanceAnti-HCV antibody screening in patients with confirmed oral lichen planus is not indicated routinely in central Germany. More... »

PAGES

193-197

References to SciGraph publications

  • 2008-12-24. How common is oral lichen planus? in EVIDENCE-BASED DENTISTRY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00784-015-1602-5

    DOI

    http://dx.doi.org/10.1007/s00784-015-1602-5

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    https://app.dimensions.ai/details/publication/pub.1023459423

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26411858


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