Stage-related treatment concept of medication-related osteonecrosis of the jaw—a case series View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-12-17

AUTHORS

Petra Rugani, Stephan Acham, Barbara Kirnbauer, Astrid Truschnegg, Barbara Obermayer-Pietsch, Norbert Jakse

ABSTRACT

ObjectivesThere is no general consensus for treatment of medication-related osteonecrosis of the jaw (MRONJ). A stage-related approach that primarily aims to minimize morbidity and preserve function was prospectively evaluated.Patients and methodsTreatment goals are stable mucosal closure and absence of clinical symptoms. Patients were enrolled between March 2010 and October 2011. MRONJ lesions were treated either by conservative means or surgically by debridement or resective surgery.ResultsIn total, 38 patients were treated. Six patients were healed by undergoing conservative measures; nine were treated palliatively. Four patients dropped out after surgery in the recall phase. In 17 of 19 patients (89.5 %) surgical treatment was successful. After a 1-year observation period, the success rate was 92 % (23 of 25), including all patients treated as per protocol.ConclusionIn stage-related treatment, conservative means or surgical debridement can be successful at early stages. Extensive resection is solely indicated in cases of extended necrosis.Clinical relevanceThe number of patients with MRONJ is steadily increasing. Guidelines to deal with this condition are helpful for both clinicians and dental practitioners. More... »

PAGES

1329-1338

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00784-014-1384-1

DOI

http://dx.doi.org/10.1007/s00784-014-1384-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016509132

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25511385


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