Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-08

AUTHORS

Lukas K. Filak, Gerhard Mühlgassner, Michael A. Jakupec, Petra Heffeter, Walter Berger, Vladimir B. Arion, Bernhard K. Keppler

ABSTRACT

The synthesis of ruthenium(II) and osmium(II) arene complexes with the closely related indolo[3,2-c]quinolines N-(11H-indolo[3,2-c]quinolin-6-yl)-ethane-1,2-diamine (L ( 1 )) and N'-(11H-indolo[3,2-c]quinolin-6-yl)-N,N-dimethylethane-1,2-diamine (L ( 2 )) and indolo[3,2-d]benzazepines N-(7,12-dihydroindolo-[3,2-d][1]benzazepin-6-yl)-ethane-1,2-diamine (L ( 3 )) and N'-(7,12-dihydroindolo-[3,2-d][1]benzazepin-6-yl)-N,N-dimethylethane-1,2-diamine (L ( 4 )) of the general formulas [(eta(6)-p-cymene)M(II)(L ( 1 ))Cl]Cl, where M is Ru (4) and Os (6), [(eta(6)-p-cymene)M(II)(L ( 2 ))Cl]Cl, where M is Ru (5) and Os (7), [(eta(6)-p-cymene)M(II)(L ( 3 ))Cl]Cl, where M is Ru (8) and Os (10), and [(eta(6)-p-cymene)M(II)(L ( 4 ))Cl]Cl, where M is Ru (9) and Os (11), is reported. The compounds have been comprehensively characterized by elemental analysis, electrospray ionization mass spectrometry, spectroscopy (IR, UV-vis, and NMR), and X-ray crystallography (L ( 1 ).HCl, 4.H(2)O, 5, and 9.2.5H(2)O). Structure-activity relationships with regard to cytotoxicity and cell cycle effects in human cancer cells as well as cyclin-dependent kinase (cdk) inhibition and DNA intercalation in cell-free settings have been established. The metal-free indolo[3,2-c]quinolines inhibit cancer cell growth in vitro, with IC(50) values in the high nanomolar range, whereas those of the related indolo[3,2-d]benzazepines are in the low micromolar range. In cell-free experiments, these classes of compounds inhibit the activity of cdk2/cyclin E, but the much higher cytotoxicity and stronger cell cycle effects of indoloquinolines L ( 1 ) and 7 are not paralleled by a substantially higher kinase inhibition compared with indolobenzazepines L ( 4 ) and 11, arguing for additional targets and molecular effects, such as intercalation into DNA. More... »

PAGES

903-918

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00775-010-0653-y

DOI

http://dx.doi.org/10.1007/s00775-010-0653-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036897686

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20369265


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Benzazepines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Crystallography, X-Ray", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inhibitory Concentration 50", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intercalating Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ligands", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organometallic Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quinolines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spectrum Analysis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.10420.37", 
          "name": [
            "Institute of Inorganic Chemistry, University of Vienna, W\u00e4hringer Stra\u00dfe 42, 1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Filak", 
        "givenName": "Lukas K.", 
        "id": "sg:person.011547735511.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011547735511.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.10420.37", 
          "name": [
            "Institute of Inorganic Chemistry, University of Vienna, W\u00e4hringer Stra\u00dfe 42, 1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "M\u00fchlgassner", 
        "givenName": "Gerhard", 
        "id": "sg:person.01163020375.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163020375.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.10420.37", 
          "name": [
            "Institute of Inorganic Chemistry, University of Vienna, W\u00e4hringer Stra\u00dfe 42, 1090, Vienna, Austria", 
            "Research Platform \u201cTranslational Cancer Therapy Research\u201d, University of Vienna, W\u00e4hringer Stra\u00dfe 42, 1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jakupec", 
        "givenName": "Michael A.", 
        "id": "sg:person.0612530166.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612530166.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria", 
            "Research Platform \u201cTranslational Cancer Therapy Research\u201d, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heffeter", 
        "givenName": "Petra", 
        "id": "sg:person.01204222651.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204222651.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria", 
            "Research Platform \u201cTranslational Cancer Therapy Research\u201d, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berger", 
        "givenName": "Walter", 
        "id": "sg:person.0735503622.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735503622.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.10420.37", 
          "name": [
            "Institute of Inorganic Chemistry, University of Vienna, W\u00e4hringer Stra\u00dfe 42, 1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arion", 
        "givenName": "Vladimir B.", 
        "id": "sg:person.01243342347.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243342347.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.10420.37", 
          "name": [
            "Institute of Inorganic Chemistry, University of Vienna, W\u00e4hringer Stra\u00dfe 42, 1090, Vienna, Austria", 
            "Research Platform \u201cTranslational Cancer Therapy Research\u201d, University of Vienna, W\u00e4hringer Stra\u00dfe 42, 1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Keppler", 
        "givenName": "Bernhard K.", 
        "id": "sg:person.0606573400.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606573400.82"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.drudis.2008.06.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001512517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00810876", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002477305", 
          "https://doi.org/10.1007/bf00810876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jorganchem.2008.09.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005783855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.leukres.2007.02.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005975972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/cpb.29.2166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006117703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2478/s11532-008-0048-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007143920", 
          "https://doi.org/10.2478/s11532-008-0048-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-328x(90)85149-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007539445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0031-9422(96)00545-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010695981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/cpb.31.1151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012551922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-894x(00)00427-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016626096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0040-4020(01)81384-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017297826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10565-006-0098-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019632488", 
          "https://doi.org/10.1007/s10565-006-0098-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10565-006-0098-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019632488", 
          "https://doi.org/10.1007/s10565-006-0098-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029467419", 
          "https://doi.org/10.1038/nbt1358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/chem.200304724", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029795012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/cpb.31.798", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031619359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2003.09.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032868154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2003.09.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032868154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cbi.2008.06.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036096700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0968-0896(02)00111-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037516157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0968-0896(02)00111-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037516157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00810043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040618486", 
          "https://doi.org/10.1007/bf00810043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0040-4020(02)01647-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043036551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0040-4020(02)01647-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043036551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/dt9740000233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048218195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2005.11.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050490196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1040-8428(00)00124-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051268563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1054/bjoc.2000.1546", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052492117", 
          "https://doi.org/10.1054/bjoc.2000.1546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1007534416561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052759314", 
          "https://doi.org/10.1023/a:1007534416561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ejic.200700206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052904677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2125.1997.tb00130.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053478777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi981990s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055216639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi981990s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055216639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ic0511120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055558239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ic0511120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055558239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ic070098j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055560390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ic070098j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055560390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ic902042a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055585205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ic902042a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055585205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja01542a035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055805901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja017482e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055818804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja017482e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055818804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja055886r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055840281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja055886r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055840281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja971707x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055867814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm00098a003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055934934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm00118a034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055935793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm00123a011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055935937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm010051m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055946461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm010051m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055946461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm060495o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055950485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm060495o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055950485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm701042w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055955135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm701042w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055955135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm9900570", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055959356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm9900570", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055959356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jo901641k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056034224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jo901641k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056034224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/om049022a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056273049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/om700813c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056280571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/om800899e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056281572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0028-1088014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057107709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2125.1997.tb00025.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061925869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074474449", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-08", 
    "datePublishedReg": "2010-08-01", 
    "description": "The synthesis of ruthenium(II) and osmium(II) arene complexes with the closely related indolo[3,2-c]quinolines N-(11H-indolo[3,2-c]quinolin-6-yl)-ethane-1,2-diamine (L ( 1 )) and N'-(11H-indolo[3,2-c]quinolin-6-yl)-N,N-dimethylethane-1,2-diamine (L ( 2 )) and indolo[3,2-d]benzazepines N-(7,12-dihydroindolo-[3,2-d][1]benzazepin-6-yl)-ethane-1,2-diamine (L ( 3 )) and N'-(7,12-dihydroindolo-[3,2-d][1]benzazepin-6-yl)-N,N-dimethylethane-1,2-diamine (L ( 4 )) of the general formulas [(eta(6)-p-cymene)M(II)(L ( 1 ))Cl]Cl, where M is Ru (4) and Os (6), [(eta(6)-p-cymene)M(II)(L ( 2 ))Cl]Cl, where M is Ru (5) and Os (7), [(eta(6)-p-cymene)M(II)(L ( 3 ))Cl]Cl, where M is Ru (8) and Os (10), and [(eta(6)-p-cymene)M(II)(L ( 4 ))Cl]Cl, where M is Ru (9) and Os (11), is reported. The compounds have been comprehensively characterized by elemental analysis, electrospray ionization mass spectrometry, spectroscopy (IR, UV-vis, and NMR), and X-ray crystallography (L ( 1 ).HCl, 4.H(2)O, 5, and 9.2.5H(2)O). Structure-activity relationships with regard to cytotoxicity and cell cycle effects in human cancer cells as well as cyclin-dependent kinase (cdk) inhibition and DNA intercalation in cell-free settings have been established. The metal-free indolo[3,2-c]quinolines inhibit cancer cell growth in vitro, with IC(50) values in the high nanomolar range, whereas those of the related indolo[3,2-d]benzazepines are in the low micromolar range. In cell-free experiments, these classes of compounds inhibit the activity of cdk2/cyclin E, but the much higher cytotoxicity and stronger cell cycle effects of indoloquinolines L ( 1 ) and 7 are not paralleled by a substantially higher kinase inhibition compared with indolobenzazepines L ( 4 ) and 11, arguing for additional targets and molecular effects, such as intercalation into DNA.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00775-010-0653-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6195505", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6190121", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1116242", 
        "issn": [
          "0949-8257", 
          "1432-1327"
        ], 
        "name": "JBIC Journal of Biological Inorganic Chemistry", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "15"
      }
    ], 
    "name": "Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy", 
    "pagination": "903-918", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "afc43cbe3913650bafacaf00364db8aa6fb38726af7678703c93645c884dca91"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20369265"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9616326"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00775-010-0653-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1036897686"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00775-010-0653-y", 
      "https://app.dimensions.ai/details/publication/pub.1036897686"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54302_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00775-010-0653-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00775-010-0653-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00775-010-0653-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00775-010-0653-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00775-010-0653-y'


 

This table displays all metadata directly associated to this object as RDF triples.

333 TRIPLES      21 PREDICATES      93 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00775-010-0653-y schema:about N06a89366f395462d8c065a8188702793
2 N3e68c569dab040a3ac1922443093f4fc
3 N47c5c27251d14912a8919611f5355dd0
4 N53d8a79b5ae94227a9bb70cfa66b3673
5 N6c888e76a12d4f4ea616d28762b01341
6 N87a5e0ce855f41f2b6a0ebdac4ce8f26
7 N8817e1c8b821453ab6bff7e42a43daf9
8 N8ba5dab6d6904a10b1e891721cf44b12
9 N92701273f82d435694b9c306f2c8f54b
10 Na08ab06b4e814b35bc2b7027f8a7daf1
11 Na58f5e6515a44d55b6e6a3652c79ce83
12 Ne2766a01aaf14f4fb4339e83cb9cd9a5
13 Ne624dc65909b4792b8aed65abb2689c8
14 Ne7cf6f655e974e64ab6d53555b2bf58a
15 Nf0827f40a55645c3b2165eb23f5b9324
16 anzsrc-for:06
17 anzsrc-for:0601
18 schema:author N49a9c71fe76743d28c4315fc9d51c010
19 schema:citation sg:pub.10.1007/bf00810043
20 sg:pub.10.1007/bf00810876
21 sg:pub.10.1007/s10565-006-0098-9
22 sg:pub.10.1023/a:1007534416561
23 sg:pub.10.1038/nbt1358
24 sg:pub.10.1054/bjoc.2000.1546
25 sg:pub.10.2478/s11532-008-0048-x
26 https://app.dimensions.ai/details/publication/pub.1074474449
27 https://doi.org/10.1002/chem.200304724
28 https://doi.org/10.1002/ejic.200700206
29 https://doi.org/10.1016/0022-328x(90)85149-s
30 https://doi.org/10.1016/j.bcp.2005.11.009
31 https://doi.org/10.1016/j.cbi.2008.06.008
32 https://doi.org/10.1016/j.cub.2003.09.024
33 https://doi.org/10.1016/j.drudis.2008.06.012
34 https://doi.org/10.1016/j.jorganchem.2008.09.023
35 https://doi.org/10.1016/j.leukres.2007.02.014
36 https://doi.org/10.1016/s0031-9422(96)00545-6
37 https://doi.org/10.1016/s0040-4020(01)81384-3
38 https://doi.org/10.1016/s0040-4020(02)01647-2
39 https://doi.org/10.1016/s0960-894x(00)00427-3
40 https://doi.org/10.1016/s0968-0896(02)00111-6
41 https://doi.org/10.1016/s1040-8428(00)00124-4
42 https://doi.org/10.1021/bi981990s
43 https://doi.org/10.1021/ic0511120
44 https://doi.org/10.1021/ic070098j
45 https://doi.org/10.1021/ic902042a
46 https://doi.org/10.1021/ja01542a035
47 https://doi.org/10.1021/ja017482e
48 https://doi.org/10.1021/ja055886r
49 https://doi.org/10.1021/ja971707x
50 https://doi.org/10.1021/jm00098a003
51 https://doi.org/10.1021/jm00118a034
52 https://doi.org/10.1021/jm00123a011
53 https://doi.org/10.1021/jm010051m
54 https://doi.org/10.1021/jm060495o
55 https://doi.org/10.1021/jm701042w
56 https://doi.org/10.1021/jm9900570
57 https://doi.org/10.1021/jo901641k
58 https://doi.org/10.1021/om049022a
59 https://doi.org/10.1021/om700813c
60 https://doi.org/10.1021/om800899e
61 https://doi.org/10.1039/dt9740000233
62 https://doi.org/10.1055/s-0028-1088014
63 https://doi.org/10.1111/j.1365-2125.1997.tb00025.x
64 https://doi.org/10.1111/j.1365-2125.1997.tb00130.x
65 https://doi.org/10.1248/cpb.29.2166
66 https://doi.org/10.1248/cpb.31.1151
67 https://doi.org/10.1248/cpb.31.798
68 schema:datePublished 2010-08
69 schema:datePublishedReg 2010-08-01
70 schema:description The synthesis of ruthenium(II) and osmium(II) arene complexes with the closely related indolo[3,2-c]quinolines N-(11H-indolo[3,2-c]quinolin-6-yl)-ethane-1,2-diamine (L ( 1 )) and N'-(11H-indolo[3,2-c]quinolin-6-yl)-N,N-dimethylethane-1,2-diamine (L ( 2 )) and indolo[3,2-d]benzazepines N-(7,12-dihydroindolo-[3,2-d][1]benzazepin-6-yl)-ethane-1,2-diamine (L ( 3 )) and N'-(7,12-dihydroindolo-[3,2-d][1]benzazepin-6-yl)-N,N-dimethylethane-1,2-diamine (L ( 4 )) of the general formulas [(eta(6)-p-cymene)M(II)(L ( 1 ))Cl]Cl, where M is Ru (4) and Os (6), [(eta(6)-p-cymene)M(II)(L ( 2 ))Cl]Cl, where M is Ru (5) and Os (7), [(eta(6)-p-cymene)M(II)(L ( 3 ))Cl]Cl, where M is Ru (8) and Os (10), and [(eta(6)-p-cymene)M(II)(L ( 4 ))Cl]Cl, where M is Ru (9) and Os (11), is reported. The compounds have been comprehensively characterized by elemental analysis, electrospray ionization mass spectrometry, spectroscopy (IR, UV-vis, and NMR), and X-ray crystallography (L ( 1 ).HCl, 4.H(2)O, 5, and 9.2.5H(2)O). Structure-activity relationships with regard to cytotoxicity and cell cycle effects in human cancer cells as well as cyclin-dependent kinase (cdk) inhibition and DNA intercalation in cell-free settings have been established. The metal-free indolo[3,2-c]quinolines inhibit cancer cell growth in vitro, with IC(50) values in the high nanomolar range, whereas those of the related indolo[3,2-d]benzazepines are in the low micromolar range. In cell-free experiments, these classes of compounds inhibit the activity of cdk2/cyclin E, but the much higher cytotoxicity and stronger cell cycle effects of indoloquinolines L ( 1 ) and 7 are not paralleled by a substantially higher kinase inhibition compared with indolobenzazepines L ( 4 ) and 11, arguing for additional targets and molecular effects, such as intercalation into DNA.
71 schema:genre research_article
72 schema:inLanguage en
73 schema:isAccessibleForFree true
74 schema:isPartOf Nb73d7cfbf05a4ce7b01d4eb6110e1599
75 Nd8de791fb7cc4493b35079e6bc5495af
76 sg:journal.1116242
77 schema:name Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy
78 schema:pagination 903-918
79 schema:productId N25164ddc60bb4007860a038818914aa2
80 N45414cd890fa4c09bcc8662beeaaf622
81 N7de12cdb729e443e97cc8591436eb9b3
82 N97f243a1e6b042078023d4eab30b4cf4
83 N9ffb8fba0dad44f48a0499ee9bf7839d
84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036897686
85 https://doi.org/10.1007/s00775-010-0653-y
86 schema:sdDatePublished 2019-04-11T10:16
87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
88 schema:sdPublisher N0483c2cb30684eebb3dffde489376fd5
89 schema:url http://link.springer.com/10.1007%2Fs00775-010-0653-y
90 sgo:license sg:explorer/license/
91 sgo:sdDataset articles
92 rdf:type schema:ScholarlyArticle
93 N0483c2cb30684eebb3dffde489376fd5 schema:name Springer Nature - SN SciGraph project
94 rdf:type schema:Organization
95 N06a89366f395462d8c065a8188702793 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Crystallography, X-Ray
97 rdf:type schema:DefinedTerm
98 N0993bde4988340e497d61aef85c01afa rdf:first sg:person.01243342347.40
99 rdf:rest N7af2d662da4c401db6f02c7c7a5ffe98
100 N1cdbaac643ae4b819ac71e23ad3a5b56 rdf:first sg:person.01163020375.79
101 rdf:rest N39ab86d988cf412ca28e5b0bdffca3f3
102 N25164ddc60bb4007860a038818914aa2 schema:name readcube_id
103 schema:value afc43cbe3913650bafacaf00364db8aa6fb38726af7678703c93645c884dca91
104 rdf:type schema:PropertyValue
105 N39ab86d988cf412ca28e5b0bdffca3f3 rdf:first sg:person.0612530166.50
106 rdf:rest N96108a3bc9c9435eb3c261a27753dab8
107 N3e68c569dab040a3ac1922443093f4fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Inhibitory Concentration 50
109 rdf:type schema:DefinedTerm
110 N45414cd890fa4c09bcc8662beeaaf622 schema:name nlm_unique_id
111 schema:value 9616326
112 rdf:type schema:PropertyValue
113 N47c5c27251d14912a8919611f5355dd0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Spectrum Analysis
115 rdf:type schema:DefinedTerm
116 N49a9c71fe76743d28c4315fc9d51c010 rdf:first sg:person.011547735511.34
117 rdf:rest N1cdbaac643ae4b819ac71e23ad3a5b56
118 N53d8a79b5ae94227a9bb70cfa66b3673 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Cell Line, Tumor
120 rdf:type schema:DefinedTerm
121 N579bd65b4c784481913383bfc291df4f rdf:first sg:person.0735503622.07
122 rdf:rest N0993bde4988340e497d61aef85c01afa
123 N6c888e76a12d4f4ea616d28762b01341 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Intercalating Agents
125 rdf:type schema:DefinedTerm
126 N7af2d662da4c401db6f02c7c7a5ffe98 rdf:first sg:person.0606573400.82
127 rdf:rest rdf:nil
128 N7de12cdb729e443e97cc8591436eb9b3 schema:name doi
129 schema:value 10.1007/s00775-010-0653-y
130 rdf:type schema:PropertyValue
131 N87a5e0ce855f41f2b6a0ebdac4ce8f26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Benzazepines
133 rdf:type schema:DefinedTerm
134 N8817e1c8b821453ab6bff7e42a43daf9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Quinolines
136 rdf:type schema:DefinedTerm
137 N8ba5dab6d6904a10b1e891721cf44b12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Cell Cycle
139 rdf:type schema:DefinedTerm
140 N92701273f82d435694b9c306f2c8f54b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name DNA
142 rdf:type schema:DefinedTerm
143 N96108a3bc9c9435eb3c261a27753dab8 rdf:first sg:person.01204222651.00
144 rdf:rest N579bd65b4c784481913383bfc291df4f
145 N97f243a1e6b042078023d4eab30b4cf4 schema:name pubmed_id
146 schema:value 20369265
147 rdf:type schema:PropertyValue
148 N9ffb8fba0dad44f48a0499ee9bf7839d schema:name dimensions_id
149 schema:value pub.1036897686
150 rdf:type schema:PropertyValue
151 Na08ab06b4e814b35bc2b7027f8a7daf1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Organometallic Compounds
153 rdf:type schema:DefinedTerm
154 Na58f5e6515a44d55b6e6a3652c79ce83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Ligands
156 rdf:type schema:DefinedTerm
157 Nb73d7cfbf05a4ce7b01d4eb6110e1599 schema:issueNumber 6
158 rdf:type schema:PublicationIssue
159 Nd8de791fb7cc4493b35079e6bc5495af schema:volumeNumber 15
160 rdf:type schema:PublicationVolume
161 Ne2766a01aaf14f4fb4339e83cb9cd9a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Animals
163 rdf:type schema:DefinedTerm
164 Ne624dc65909b4792b8aed65abb2689c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Cyclin-Dependent Kinases
166 rdf:type schema:DefinedTerm
167 Ne7cf6f655e974e64ab6d53555b2bf58a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Antineoplastic Agents
169 rdf:type schema:DefinedTerm
170 Nf0827f40a55645c3b2165eb23f5b9324 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Humans
172 rdf:type schema:DefinedTerm
173 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
174 schema:name Biological Sciences
175 rdf:type schema:DefinedTerm
176 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
177 schema:name Biochemistry and Cell Biology
178 rdf:type schema:DefinedTerm
179 sg:grant.6190121 http://pending.schema.org/fundedItem sg:pub.10.1007/s00775-010-0653-y
180 rdf:type schema:MonetaryGrant
181 sg:grant.6195505 http://pending.schema.org/fundedItem sg:pub.10.1007/s00775-010-0653-y
182 rdf:type schema:MonetaryGrant
183 sg:journal.1116242 schema:issn 0949-8257
184 1432-1327
185 schema:name JBIC Journal of Biological Inorganic Chemistry
186 rdf:type schema:Periodical
187 sg:person.011547735511.34 schema:affiliation https://www.grid.ac/institutes/grid.10420.37
188 schema:familyName Filak
189 schema:givenName Lukas K.
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011547735511.34
191 rdf:type schema:Person
192 sg:person.01163020375.79 schema:affiliation https://www.grid.ac/institutes/grid.10420.37
193 schema:familyName Mühlgassner
194 schema:givenName Gerhard
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163020375.79
196 rdf:type schema:Person
197 sg:person.01204222651.00 schema:affiliation https://www.grid.ac/institutes/grid.22937.3d
198 schema:familyName Heffeter
199 schema:givenName Petra
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204222651.00
201 rdf:type schema:Person
202 sg:person.01243342347.40 schema:affiliation https://www.grid.ac/institutes/grid.10420.37
203 schema:familyName Arion
204 schema:givenName Vladimir B.
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243342347.40
206 rdf:type schema:Person
207 sg:person.0606573400.82 schema:affiliation https://www.grid.ac/institutes/grid.10420.37
208 schema:familyName Keppler
209 schema:givenName Bernhard K.
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606573400.82
211 rdf:type schema:Person
212 sg:person.0612530166.50 schema:affiliation https://www.grid.ac/institutes/grid.10420.37
213 schema:familyName Jakupec
214 schema:givenName Michael A.
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612530166.50
216 rdf:type schema:Person
217 sg:person.0735503622.07 schema:affiliation https://www.grid.ac/institutes/grid.22937.3d
218 schema:familyName Berger
219 schema:givenName Walter
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735503622.07
221 rdf:type schema:Person
222 sg:pub.10.1007/bf00810043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040618486
223 https://doi.org/10.1007/bf00810043
224 rdf:type schema:CreativeWork
225 sg:pub.10.1007/bf00810876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002477305
226 https://doi.org/10.1007/bf00810876
227 rdf:type schema:CreativeWork
228 sg:pub.10.1007/s10565-006-0098-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019632488
229 https://doi.org/10.1007/s10565-006-0098-9
230 rdf:type schema:CreativeWork
231 sg:pub.10.1023/a:1007534416561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052759314
232 https://doi.org/10.1023/a:1007534416561
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/nbt1358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029467419
235 https://doi.org/10.1038/nbt1358
236 rdf:type schema:CreativeWork
237 sg:pub.10.1054/bjoc.2000.1546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052492117
238 https://doi.org/10.1054/bjoc.2000.1546
239 rdf:type schema:CreativeWork
240 sg:pub.10.2478/s11532-008-0048-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007143920
241 https://doi.org/10.2478/s11532-008-0048-x
242 rdf:type schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1074474449 schema:CreativeWork
244 https://doi.org/10.1002/chem.200304724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029795012
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1002/ejic.200700206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052904677
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/0022-328x(90)85149-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1007539445
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.bcp.2005.11.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050490196
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.cbi.2008.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036096700
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.cub.2003.09.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032868154
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.drudis.2008.06.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001512517
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.jorganchem.2008.09.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005783855
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.leukres.2007.02.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005975972
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/s0031-9422(96)00545-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010695981
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/s0040-4020(01)81384-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017297826
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/s0040-4020(02)01647-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043036551
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/s0960-894x(00)00427-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016626096
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/s0968-0896(02)00111-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037516157
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/s1040-8428(00)00124-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051268563
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1021/bi981990s schema:sameAs https://app.dimensions.ai/details/publication/pub.1055216639
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1021/ic0511120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055558239
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1021/ic070098j schema:sameAs https://app.dimensions.ai/details/publication/pub.1055560390
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1021/ic902042a schema:sameAs https://app.dimensions.ai/details/publication/pub.1055585205
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1021/ja01542a035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055805901
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1021/ja017482e schema:sameAs https://app.dimensions.ai/details/publication/pub.1055818804
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1021/ja055886r schema:sameAs https://app.dimensions.ai/details/publication/pub.1055840281
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1021/ja971707x schema:sameAs https://app.dimensions.ai/details/publication/pub.1055867814
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1021/jm00098a003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055934934
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1021/jm00118a034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055935793
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1021/jm00123a011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055935937
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1021/jm010051m schema:sameAs https://app.dimensions.ai/details/publication/pub.1055946461
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1021/jm060495o schema:sameAs https://app.dimensions.ai/details/publication/pub.1055950485
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1021/jm701042w schema:sameAs https://app.dimensions.ai/details/publication/pub.1055955135
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1021/jm9900570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055959356
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1021/jo901641k schema:sameAs https://app.dimensions.ai/details/publication/pub.1056034224
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1021/om049022a schema:sameAs https://app.dimensions.ai/details/publication/pub.1056273049
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1021/om700813c schema:sameAs https://app.dimensions.ai/details/publication/pub.1056280571
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1021/om800899e schema:sameAs https://app.dimensions.ai/details/publication/pub.1056281572
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1039/dt9740000233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048218195
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1055/s-0028-1088014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057107709
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1111/j.1365-2125.1997.tb00025.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1061925869
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1111/j.1365-2125.1997.tb00130.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053478777
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1248/cpb.29.2166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006117703
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1248/cpb.31.1151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012551922
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1248/cpb.31.798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031619359
325 rdf:type schema:CreativeWork
326 https://www.grid.ac/institutes/grid.10420.37 schema:alternateName University of Vienna
327 schema:name Institute of Inorganic Chemistry, University of Vienna, Währinger Straße 42, 1090, Vienna, Austria
328 Research Platform “Translational Cancer Therapy Research”, University of Vienna, Währinger Straße 42, 1090, Vienna, Austria
329 rdf:type schema:Organization
330 https://www.grid.ac/institutes/grid.22937.3d schema:alternateName Medical University of Vienna
331 schema:name Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria
332 Research Platform “Translational Cancer Therapy Research”, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria
333 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...