Synthesis, characterization, antitumoral and osteogenic activities of quercetin vanadyl(IV) complexes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-07-05

AUTHORS

Evelina G. Ferrer, María V. Salinas, María J. Correa, Luciana Naso, Daniel A. Barrio, Susana B. Etcheverry, Luis Lezama, Teófilo Rojo, Patricia A. M. Williams

ABSTRACT

The development of new vanadium derivatives with organic ligands, which improve the beneficial actions (insulin-mimetic, antitumoral) and decrease the toxic effects, is of great interest. A good candidate for the generation of a new vanadium compound is the flavonoid quercetin because of its own anticarcinogenic effect. The complex [VO(Quer)2EtOH]n (QuerVO) has been synthesized and characterized by means of different spectroscopic techniques (UV–vis, Fourier transform IR, electron paramagnetic resonance) and its magnetic and stability properties. The inhibitory effect on bovine alkaline phosphatase (ALP) activity has been tested for the free ligand, the complex as well as for the vanadyl(IV) (comparative purposes). The biological activity of the complex on the proliferation of two osteoblast-like cells in culture, a normal one (MC3T3E1) and a tumoral one (UMR106), has been compared with that of the vanadyl(IV) cation and quercetin. The differentiation osteoblast markers ALP specific activity and collagen synthesis have been also tested. In addition, the effect of QuerVO on the activation of the extracellular regulated kinase (ERK) pathway is reported. The bone antitumoral effect of quercetin alone was established with the cell proliferation assays (it inhibits the proliferation of the tumoral cells and does not exert any effect on the normal osteoblasts). Moreover, the complex exerts osteogenic effects since it stimulates the type I collagen production and is a weak inhibitory agent upon ALP activity. Finally, QuerVO stimulated the ERK phosphorylation in a dose–response manner and this activation seems to be involved as one of the possible mechanisms for the biological effects of the complex. More... »

PAGES

791-801

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00775-006-0122-9

DOI

http://dx.doi.org/10.1007/s00775-006-0122-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005311966

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16821038


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33 schema:description The development of new vanadium derivatives with organic ligands, which improve the beneficial actions (insulin-mimetic, antitumoral) and decrease the toxic effects, is of great interest. A good candidate for the generation of a new vanadium compound is the flavonoid quercetin because of its own anticarcinogenic effect. The complex [VO(Quer)2EtOH]n (QuerVO) has been synthesized and characterized by means of different spectroscopic techniques (UV–vis, Fourier transform IR, electron paramagnetic resonance) and its magnetic and stability properties. The inhibitory effect on bovine alkaline phosphatase (ALP) activity has been tested for the free ligand, the complex as well as for the vanadyl(IV) (comparative purposes). The biological activity of the complex on the proliferation of two osteoblast-like cells in culture, a normal one (MC3T3E1) and a tumoral one (UMR106), has been compared with that of the vanadyl(IV) cation and quercetin. The differentiation osteoblast markers ALP specific activity and collagen synthesis have been also tested. In addition, the effect of QuerVO on the activation of the extracellular regulated kinase (ERK) pathway is reported. The bone antitumoral effect of quercetin alone was established with the cell proliferation assays (it inhibits the proliferation of the tumoral cells and does not exert any effect on the normal osteoblasts). Moreover, the complex exerts osteogenic effects since it stimulates the type I collagen production and is a weak inhibitory agent upon ALP activity. Finally, QuerVO stimulated the ERK phosphorylation in a dose–response manner and this activation seems to be involved as one of the possible mechanisms for the biological effects of the complex.
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41 ALP specific activity
42 ERK phosphorylation
43 QuerVO
44 action
45 activation
46 activity
47 addition
48 agents
49 alkaline phosphatase activity
50 anticarcinogenic effects
51 antitumoral effect
52 beneficial actions
53 biological activity
54 biological effects
55 bone antitumoral effect
56 bovine alkaline phosphatase (ALP) activity
57 candidates
58 cations
59 cell proliferation
60 cells
61 characterization
62 collagen synthesis
63 complex exerts osteogenic effects
64 complexes
65 compounds
66 culture
67 derivatives
68 development
69 different spectroscopic techniques
70 differentiation osteoblast
71 dose-response manner
72 effect
73 effect of QuerVO
74 exerts osteogenic effects
75 flavonoid quercetin
76 free ligand
77 generation
78 good candidate
79 great interest
80 inhibitory agents
81 inhibitory effect
82 interest
83 kinase pathway
84 ligands
85 manner
86 means
87 mechanism
88 new vanadium compounds
89 new vanadium derivatives
90 organic ligands
91 osteoblast-like cells
92 osteoblasts
93 osteogenic activity
94 osteogenic effect
95 own anticarcinogenic effect
96 pathway
97 phosphatase activity
98 phosphorylation
99 possible mechanism
100 production
101 proliferation
102 properties
103 quercetin
104 specific activity
105 spectroscopic techniques
106 stability properties
107 synthesis
108 technique
109 toxic effects
110 type I
111 vanadium compounds
112 vanadium derivatives
113 weak inhibitory agent
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