The 1.13-Å structure of iron-free cytochrome c peroxidase View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-06

AUTHORS

B. Bhaskar, Thomas L. Poulos

ABSTRACT

The iron-free cytochrome c peroxidase (CCP) crystal structure has been determined to 1.13 A and compared with the 1.2-A ferric-CCP structure. Quite unexpectedly, removal of the iron has no effect on porphyrin geometry and distortion, indicating that protein-porphyrin interactions and not iron coordination or formation of the axial His-Fe bond determines porphyrin conformation. However, there are changes in solvent structure in the distal pocket, which lead to changes in the distal His52 acid-base catalyst. The observed ability of His52 to move in response to small changes in solvent structure is very likely important for its role as a catalyst in assisting in the heterolytic fission of the peroxide O-O bond. More... »

PAGES

425-430

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00775-005-0654-4

DOI

http://dx.doi.org/10.1007/s00775-005-0654-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017878860

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15900441


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