Bone marrow lesion is associated with disability for activities of daily living in patients with early stage knee osteoarthritis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-09-05

AUTHORS

Ryo Sadatsuki, Muneaki Ishijima, Haruka Kaneko, Lizu Liu, Ippei Futami, Shinnosuke Hada, Mayuko Kinoshita, Mitsuaki Kubota, Takako Aoki, Yuji Takazawa, Hiroshi Ikeda, Yasunori Okada, Kazuo Kaneko

ABSTRACT

Osteoarthritis of the knee (knee OA) induces pain, loss of mobility and diminished activities of daily living (ADL). Although an understanding of the pathophysiology of early stage knee OA has been developed, the structural changes associated with disability for ADL in early stage knee OA are still unclear. The aim of the present study was to examine magnetic resonance imaging (MRI)-detected changes associated with disability for ADL in patients with early stage knee OA. One hundred and thirty-two patients with early stage medial knee OA (Kellgren–Lawrence grade ≤ 2) who first visited the outpatient clinic at our university hospital were included. They were also examined by 3.0-Tesla knee MRI. The OA-associated structural changes were scored using the Whole-Organ Magnetic Resonance Imaging Score (WORMS), and clinical manifestations were evaluated by the Japanese Knee Osteoarthritis Measure (JKOM). Median quartile regression was used for the analysis. Cartilage lesion, subchondral bone attrition and osteophytes were observed in all patients. Bone marrow lesions (BMLs) and synovitis were observed in 60% and 55% of the patients, respectively. Subchondral cysts and ligament changes were observed in 6% and 17% of the patients, respectively. Pain severity of the patients was associated with medial cartilage lesions (coefficient 2.50, 95% confidence interval 0.61–4.40, p < 0.01). Disability for ADL of the patients was associated with BMLs in the medial side of the knee joint (0.82, 0.21–1.02, p = 0.04). BMLs in the medial side of the knee joint were associated with disability for ADL of patients with early stage medial knee OA. More... »

PAGES

529-536

References to SciGraph publications

  • 2016-05-27. Osteoarthritis as a Cause of Locomotive Syndrome: Its Influence on Functional Mobility and Activities of Daily Living in CLINICAL REVIEWS IN BONE AND MINERAL METABOLISM
  • 2010-06-22. Correlation between synovitis detected on enhanced-magnetic resonance imaging and a histological analysis with a patient-oriented outcome measure for Japanese patients with end-stage knee osteoarthritis receiving joint replacement surgery in CLINICAL RHEUMATOLOGY
  • 2011-02-14. Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis in ARTHRITIS RESEARCH & THERAPY
  • 2016-09-22. Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage–bone crosstalk in NATURE REVIEWS RHEUMATOLOGY
  • 2010-09. A longitudinal study of the relationship between the status of bone marrow abnormalities and progression of knee osteoarthritis in JOURNAL OF ORTHOPAEDIC SCIENCE
  • 2012-05-22. Meniscus pathology, osteoarthritis and the treatment controversy in NATURE REVIEWS RHEUMATOLOGY
  • 2017-09-12. Association of medial meniscal extrusion with medial tibial osteophyte distance detected by T2 mapping MRI in patients with early-stage knee osteoarthritis in ARTHRITIS RESEARCH & THERAPY
  • 2017-09-12. Serum interleukin 6 levels are associated with depressive state of the patients with knee osteoarthritis irrespective of disease severity in CLINICAL RHEUMATOLOGY
  • 2010-12-29. Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adults in ARTHRITIS RESEARCH & THERAPY
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/s00774-018-0950-z

    DOI

    http://dx.doi.org/10.1007/s00774-018-0950-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1106679602

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30187274


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