Higher serum uric acid is associated with higher lumbar spine bone mineral density in male health-screening examinees: a cross-sectional study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-01-25

AUTHORS

Jiwon Hwang, Jung Hye Hwang, Seungho Ryu, Joong Kyong Ahn

ABSTRACT

Bone health has been associated with oxidative stress and antioxidants have received interest to this end. Serum uric acid (SUA), an end product of purine metabolism in humans, has recently shown antioxidant properties regarding bone health, but there are conflicting results. The aim of this study was to investigate the relationship between SUA levels and lumbar spine bone mineral density (BMD) in clinically apparently healthy males aged 40–60 years. We performed a cross-sectional study of 6588 Korean males who completed a health-screening program from January 2011 to December 2014. Of the study participants, the mean age was 48.2 ± 10.7 years. Multiple regression analyses resulted in a significant positive association with lumbar spine BMD across SUA quintiles in a dose–response manner after adjusting for various confounding factors (p = 0.013); for each 1 mg/dl increase of SUA, BMD rose by 0.0054 g/cm2 (p = 0.004). Stratified analyses revealed that this association between SUA and lumbar spine BMD was consistently observed across all clinically relevant subgroups. The present study demonstrated a positive association in males between SUA and lumbar spine BMD, suggesting that SUA could have a profitable effect on bone metabolism. More... »

PAGES

142-151

References to SciGraph publications

  • 2014-09-25. Association of body composition with bone mineral density in northern Chinese men by different criteria for obesity in JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • 2012-09-04. Uric acid as a danger signal in gout and its comorbidities in NATURE REVIEWS RHEUMATOLOGY
  • 2013-04-04. The effect of physical exercise on bone density in middle-aged and older men: A systematic review in OSTEOPOROSIS INTERNATIONAL
  • 2008-03-29. Safety of parathyroid hormone for the treatment of osteoporosis in CURRENT OSTEOPOROSIS REPORTS
  • 1998. Decreased Serum Concentrations of 1,25(OH)2-Vitamin D3 in Patients with Gout in PURINE AND PYRIMIDINE METABOLISM IN MAN IX
  • 2013-05-04. Higher serum uric acid is associated with higher bone mass, lower bone turnover, and lower prevalence of vertebral fracture in healthy postmenopausal women in OSTEOPOROSIS INTERNATIONAL
  • 2014-03-26. Higher serum uric acid as a protective factor against incident osteoporotic fractures in Korean men: a longitudinal study using the National Claim Registry in OSTEOPOROSIS INTERNATIONAL
  • 2007-02-07. Validation and reproducibility of food frequency questionnaire for Korean genome epidemiologic study in EUROPEAN JOURNAL OF CLINICAL NUTRITION
  • 2013-12-07. Association between serum uric acid and lumbar spine bone mineral density in peri- and postmenopausal Japanese women in OSTEOPOROSIS INTERNATIONAL
  • 2015-03-03. Serum uric acid is associated with quantitative ultrasound parameters in men: data from the Camargo cohort in OSTEOPOROSIS INTERNATIONAL
  • 2006-08-29. Lycopene consumption decreases oxidative stress and bone resorption markers in postmenopausal women in OSTEOPOROSIS INTERNATIONAL
  • 2011-08-19. Male Osteoporosis: Epidemiology and the Pathogenesis of Aging Bones in CURRENT OSTEOPOROSIS REPORTS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00774-018-0905-4

    DOI

    http://dx.doi.org/10.1007/s00774-018-0905-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1100621532

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29372335


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Alcoholism", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ascorbic Acid", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Body Mass Index", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bone Density", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "C-Reactive Protein", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Calcium", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cross-Sectional Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diet", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Exercise", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glomerular Filtration Rate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Insulin Resistance", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lumbar Vertebrae", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mass Screening", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Smoking", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Uric Acid", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Internal Medicine, National Police Hospital, Seoul, Republic of Korea", 
              "id": "http://www.grid.ac/institutes/grid.415671.0", 
              "name": [
                "Department of Internal Medicine, National Police Hospital, Seoul, Republic of Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hwang", 
            "givenName": "Jiwon", 
            "id": "sg:person.01166345411.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166345411.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Health Promotion, Samsung Medical Center, Seoul, Republic of Korea", 
              "id": "http://www.grid.ac/institutes/grid.414964.a", 
              "name": [
                "Center for Health Promotion, Samsung Medical Center, Seoul, Republic of Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hwang", 
            "givenName": "Jung Hye", 
            "id": "sg:person.014120327353.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014120327353.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea", 
              "id": "http://www.grid.ac/institutes/grid.264381.a", 
              "name": [
                "Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Samsung Main Building B2, 67 Sejong-daero, Jung-gu, 04514, Seoul, Republic of Korea", 
                "Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea", 
                "Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ryu", 
            "givenName": "Seungho", 
            "id": "sg:person.0663521553.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663521553.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Rheumatology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, 03181, Seoul, Republic of Korea", 
              "id": "http://www.grid.ac/institutes/grid.264381.a", 
              "name": [
                "Division of Rheumatology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, 03181, Seoul, Republic of Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ahn", 
            "givenName": "Joong Kyong", 
            "id": "sg:person.01224131256.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224131256.76"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00198-006-0205-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049224357", 
              "https://doi.org/10.1007/s00198-006-0205-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrrheum.2012.143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026279140", 
              "https://doi.org/10.1038/nrrheum.2012.143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-013-2571-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048776057", 
              "https://doi.org/10.1007/s00198-013-2571-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-015-3083-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011444020", 
              "https://doi.org/10.1007/s00198-015-3083-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ejcn.1602657", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042466608", 
              "https://doi.org/10.1038/sj.ejcn.1602657"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11914-008-0003-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033941038", 
              "https://doi.org/10.1007/s11914-008-0003-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11914-011-0066-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010310284", 
              "https://doi.org/10.1007/s11914-011-0066-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-014-2697-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017715580", 
              "https://doi.org/10.1007/s00198-014-2697-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-013-2346-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036688328", 
              "https://doi.org/10.1007/s00198-013-2346-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-013-2377-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049259339", 
              "https://doi.org/10.1007/s00198-013-2377-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4615-5381-6_11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013340602", 
              "https://doi.org/10.1007/978-1-4615-5381-6_11"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40618-014-0167-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050389628", 
              "https://doi.org/10.1007/s40618-014-0167-5"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-01-25", 
        "datePublishedReg": "2018-01-25", 
        "description": "Bone health has been associated with oxidative stress and antioxidants have received interest to this end. Serum uric acid (SUA), an end product of purine metabolism in humans, has recently shown antioxidant properties regarding bone health, but there are conflicting results. The aim of this study was to investigate the relationship between SUA levels and lumbar spine bone mineral density (BMD) in clinically apparently healthy males aged 40\u201360\u00a0years. We performed a cross-sectional study of 6588 Korean males who completed a health-screening program from January 2011 to December 2014. Of the study participants, the mean age was 48.2\u00a0\u00b1\u00a010.7\u00a0years. Multiple regression analyses resulted in a significant positive association with lumbar spine BMD across SUA quintiles in a dose\u2013response manner after adjusting for various confounding factors (p\u00a0=\u00a00.013); for each 1\u00a0mg/dl increase of SUA, BMD rose by 0.0054\u00a0g/cm2 (p\u00a0=\u00a00.004). Stratified analyses revealed that this association between SUA and lumbar spine BMD was consistently observed across all clinically relevant subgroups. The present study demonstrated a positive association in males between SUA and lumbar spine BMD, suggesting that SUA could have a profitable effect on bone metabolism.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00774-018-0905-4", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1312216", 
            "issn": [
              "0914-8779", 
              "1435-5604"
            ], 
            "name": "Journal of Bone and Mineral Metabolism", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "37"
          }
        ], 
        "keywords": [
          "lumbar spine bone mineral density", 
          "spine bone mineral density", 
          "serum uric acid", 
          "bone mineral density", 
          "cross-sectional study", 
          "bone health", 
          "mineral density", 
          "higher lumbar spine bone mineral density", 
          "health-screening program", 
          "higher serum uric acid", 
          "dose-response manner", 
          "uric acid", 
          "positive association", 
          "significant positive association", 
          "dL increase", 
          "SUA levels", 
          "mean age", 
          "bone metabolism", 
          "healthy males", 
          "stratified analysis", 
          "SUA quintiles", 
          "confounding factors", 
          "study participants", 
          "relevant subgroups", 
          "Korean males", 
          "oxidative stress", 
          "multiple regression analysis", 
          "purine metabolism", 
          "regression analysis", 
          "males", 
          "present study", 
          "association", 
          "antioxidant properties", 
          "health", 
          "metabolism", 
          "end products", 
          "years", 
          "study", 
          "quintile", 
          "age", 
          "subgroups", 
          "profitable effects", 
          "participants", 
          "humans", 
          "aim", 
          "antioxidants", 
          "acid", 
          "factors", 
          "levels", 
          "increase", 
          "effect", 
          "analysis", 
          "manner", 
          "examinees", 
          "program", 
          "stress", 
          "relationship", 
          "end", 
          "results", 
          "interest", 
          "density", 
          "products", 
          "cm2", 
          "properties", 
          "male health-screening examinees", 
          "health-screening examinees"
        ], 
        "name": "Higher serum uric acid is associated with higher lumbar spine bone mineral density in male health-screening examinees: a cross-sectional study", 
        "pagination": "142-151", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1100621532"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00774-018-0905-4"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29372335"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00774-018-0905-4", 
          "https://app.dimensions.ai/details/publication/pub.1100621532"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-12-01T19:40", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_763.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00774-018-0905-4"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00774-018-0905-4'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00774-018-0905-4'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00774-018-0905-4'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00774-018-0905-4'


     

    This table displays all metadata directly associated to this object as RDF triples.

    279 TRIPLES      22 PREDICATES      122 URIs      102 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00774-018-0905-4 schema:about N0634518aea4e4708b820b0f5e095a25e
    2 N0993a71efa3b4572961de8ada03d0bd4
    3 N250cb219fc6140f38c0afe91ef1d2b87
    4 N305947fbffef490cb774a282dccb042a
    5 N32cbd53c2c664415a988459b1ce71c4f
    6 N4bcbdc6c24cf4e2f98657711712ff70e
    7 N545656e029734cda8078ce2946b7a9e6
    8 N63d807af736f48f6bbce715d74d981e4
    9 N80f053132e854d26819796b5ec64c1ff
    10 N9716ae385dc54d45a98791c6641e80e9
    11 N9cadfbf4a9b942d5af6a91bd38b6c746
    12 Nb30520f785d6438ea10aa3e0110ff332
    13 Nb6ee037704894a70a985ecba7914b000
    14 Nd01b887fd97a403288fff9fc0da535bc
    15 Ndf58e01399b04c15b695fed2c23f52d8
    16 Neb450e63d98743e39d86d05a61a13ba6
    17 Ned86d6204759429e8b80151870299344
    18 Nf34f42742ec34b6abc8a3ddfe72e36ed
    19 anzsrc-for:11
    20 anzsrc-for:1103
    21 schema:author Necc6c754f190411e9247eab309a4ea56
    22 schema:citation sg:pub.10.1007/978-1-4615-5381-6_11
    23 sg:pub.10.1007/s00198-006-0205-z
    24 sg:pub.10.1007/s00198-013-2346-1
    25 sg:pub.10.1007/s00198-013-2377-7
    26 sg:pub.10.1007/s00198-013-2571-7
    27 sg:pub.10.1007/s00198-014-2697-2
    28 sg:pub.10.1007/s00198-015-3083-4
    29 sg:pub.10.1007/s11914-008-0003-y
    30 sg:pub.10.1007/s11914-011-0066-z
    31 sg:pub.10.1007/s40618-014-0167-5
    32 sg:pub.10.1038/nrrheum.2012.143
    33 sg:pub.10.1038/sj.ejcn.1602657
    34 schema:datePublished 2018-01-25
    35 schema:datePublishedReg 2018-01-25
    36 schema:description Bone health has been associated with oxidative stress and antioxidants have received interest to this end. Serum uric acid (SUA), an end product of purine metabolism in humans, has recently shown antioxidant properties regarding bone health, but there are conflicting results. The aim of this study was to investigate the relationship between SUA levels and lumbar spine bone mineral density (BMD) in clinically apparently healthy males aged 40–60 years. We performed a cross-sectional study of 6588 Korean males who completed a health-screening program from January 2011 to December 2014. Of the study participants, the mean age was 48.2 ± 10.7 years. Multiple regression analyses resulted in a significant positive association with lumbar spine BMD across SUA quintiles in a dose–response manner after adjusting for various confounding factors (p = 0.013); for each 1 mg/dl increase of SUA, BMD rose by 0.0054 g/cm2 (p = 0.004). Stratified analyses revealed that this association between SUA and lumbar spine BMD was consistently observed across all clinically relevant subgroups. The present study demonstrated a positive association in males between SUA and lumbar spine BMD, suggesting that SUA could have a profitable effect on bone metabolism.
    37 schema:genre article
    38 schema:inLanguage en
    39 schema:isAccessibleForFree false
    40 schema:isPartOf N23c259943d7646239eda73cc4d4f1e0b
    41 N47dc403b3e134d1a9481164f03656d1f
    42 sg:journal.1312216
    43 schema:keywords Korean males
    44 SUA levels
    45 SUA quintiles
    46 acid
    47 age
    48 aim
    49 analysis
    50 antioxidant properties
    51 antioxidants
    52 association
    53 bone health
    54 bone metabolism
    55 bone mineral density
    56 cm2
    57 confounding factors
    58 cross-sectional study
    59 dL increase
    60 density
    61 dose-response manner
    62 effect
    63 end
    64 end products
    65 examinees
    66 factors
    67 health
    68 health-screening examinees
    69 health-screening program
    70 healthy males
    71 higher lumbar spine bone mineral density
    72 higher serum uric acid
    73 humans
    74 increase
    75 interest
    76 levels
    77 lumbar spine bone mineral density
    78 male health-screening examinees
    79 males
    80 manner
    81 mean age
    82 metabolism
    83 mineral density
    84 multiple regression analysis
    85 oxidative stress
    86 participants
    87 positive association
    88 present study
    89 products
    90 profitable effects
    91 program
    92 properties
    93 purine metabolism
    94 quintile
    95 regression analysis
    96 relationship
    97 relevant subgroups
    98 results
    99 serum uric acid
    100 significant positive association
    101 spine bone mineral density
    102 stratified analysis
    103 stress
    104 study
    105 study participants
    106 subgroups
    107 uric acid
    108 years
    109 schema:name Higher serum uric acid is associated with higher lumbar spine bone mineral density in male health-screening examinees: a cross-sectional study
    110 schema:pagination 142-151
    111 schema:productId N428ac8b7a5a642ea89f5ff4d6526f863
    112 N42d6084cf9bd48f1bf38c988e5eb9a78
    113 Na801915c5fc84d52a9ce261d468ede1c
    114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100621532
    115 https://doi.org/10.1007/s00774-018-0905-4
    116 schema:sdDatePublished 2021-12-01T19:40
    117 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    118 schema:sdPublisher N164dd83d3b5d43d2a2761c0c81e0e407
    119 schema:url https://doi.org/10.1007/s00774-018-0905-4
    120 sgo:license sg:explorer/license/
    121 sgo:sdDataset articles
    122 rdf:type schema:ScholarlyArticle
    123 N0634518aea4e4708b820b0f5e095a25e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Calcium
    125 rdf:type schema:DefinedTerm
    126 N0993a71efa3b4572961de8ada03d0bd4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Middle Aged
    128 rdf:type schema:DefinedTerm
    129 N164dd83d3b5d43d2a2761c0c81e0e407 schema:name Springer Nature - SN SciGraph project
    130 rdf:type schema:Organization
    131 N23c259943d7646239eda73cc4d4f1e0b schema:volumeNumber 37
    132 rdf:type schema:PublicationVolume
    133 N250cb219fc6140f38c0afe91ef1d2b87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Mass Screening
    135 rdf:type schema:DefinedTerm
    136 N305947fbffef490cb774a282dccb042a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Insulin Resistance
    138 rdf:type schema:DefinedTerm
    139 N32cbd53c2c664415a988459b1ce71c4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Smoking
    141 rdf:type schema:DefinedTerm
    142 N428ac8b7a5a642ea89f5ff4d6526f863 schema:name doi
    143 schema:value 10.1007/s00774-018-0905-4
    144 rdf:type schema:PropertyValue
    145 N42d6084cf9bd48f1bf38c988e5eb9a78 schema:name dimensions_id
    146 schema:value pub.1100621532
    147 rdf:type schema:PropertyValue
    148 N44399f883e164a6ea89247110ba9dfb9 rdf:first sg:person.01224131256.76
    149 rdf:rest rdf:nil
    150 N47dc403b3e134d1a9481164f03656d1f schema:issueNumber 1
    151 rdf:type schema:PublicationIssue
    152 N4bcbdc6c24cf4e2f98657711712ff70e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Bone Density
    154 rdf:type schema:DefinedTerm
    155 N545656e029734cda8078ce2946b7a9e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Exercise
    157 rdf:type schema:DefinedTerm
    158 N63d807af736f48f6bbce715d74d981e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Glomerular Filtration Rate
    160 rdf:type schema:DefinedTerm
    161 N80f053132e854d26819796b5ec64c1ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name C-Reactive Protein
    163 rdf:type schema:DefinedTerm
    164 N951080e265864c5c9f11147ba1fa3550 rdf:first sg:person.0663521553.03
    165 rdf:rest N44399f883e164a6ea89247110ba9dfb9
    166 N9716ae385dc54d45a98791c6641e80e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Lumbar Vertebrae
    168 rdf:type schema:DefinedTerm
    169 N9cadfbf4a9b942d5af6a91bd38b6c746 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Humans
    171 rdf:type schema:DefinedTerm
    172 Na801915c5fc84d52a9ce261d468ede1c schema:name pubmed_id
    173 schema:value 29372335
    174 rdf:type schema:PropertyValue
    175 Nb30520f785d6438ea10aa3e0110ff332 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Cross-Sectional Studies
    177 rdf:type schema:DefinedTerm
    178 Nb6ee037704894a70a985ecba7914b000 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Male
    180 rdf:type schema:DefinedTerm
    181 Nd01b887fd97a403288fff9fc0da535bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Alcoholism
    183 rdf:type schema:DefinedTerm
    184 Nd8d6b26a5d2e4b39b29dc9a54c36ea0c rdf:first sg:person.014120327353.59
    185 rdf:rest N951080e265864c5c9f11147ba1fa3550
    186 Ndf58e01399b04c15b695fed2c23f52d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Uric Acid
    188 rdf:type schema:DefinedTerm
    189 Neb450e63d98743e39d86d05a61a13ba6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Ascorbic Acid
    191 rdf:type schema:DefinedTerm
    192 Necc6c754f190411e9247eab309a4ea56 rdf:first sg:person.01166345411.20
    193 rdf:rest Nd8d6b26a5d2e4b39b29dc9a54c36ea0c
    194 Ned86d6204759429e8b80151870299344 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Diet
    196 rdf:type schema:DefinedTerm
    197 Nf34f42742ec34b6abc8a3ddfe72e36ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Body Mass Index
    199 rdf:type schema:DefinedTerm
    200 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    201 schema:name Medical and Health Sciences
    202 rdf:type schema:DefinedTerm
    203 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    204 schema:name Clinical Sciences
    205 rdf:type schema:DefinedTerm
    206 sg:journal.1312216 schema:issn 0914-8779
    207 1435-5604
    208 schema:name Journal of Bone and Mineral Metabolism
    209 schema:publisher Springer Nature
    210 rdf:type schema:Periodical
    211 sg:person.01166345411.20 schema:affiliation grid-institutes:grid.415671.0
    212 schema:familyName Hwang
    213 schema:givenName Jiwon
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166345411.20
    215 rdf:type schema:Person
    216 sg:person.01224131256.76 schema:affiliation grid-institutes:grid.264381.a
    217 schema:familyName Ahn
    218 schema:givenName Joong Kyong
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224131256.76
    220 rdf:type schema:Person
    221 sg:person.014120327353.59 schema:affiliation grid-institutes:grid.414964.a
    222 schema:familyName Hwang
    223 schema:givenName Jung Hye
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014120327353.59
    225 rdf:type schema:Person
    226 sg:person.0663521553.03 schema:affiliation grid-institutes:grid.264381.a
    227 schema:familyName Ryu
    228 schema:givenName Seungho
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663521553.03
    230 rdf:type schema:Person
    231 sg:pub.10.1007/978-1-4615-5381-6_11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013340602
    232 https://doi.org/10.1007/978-1-4615-5381-6_11
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1007/s00198-006-0205-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1049224357
    235 https://doi.org/10.1007/s00198-006-0205-z
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1007/s00198-013-2346-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036688328
    238 https://doi.org/10.1007/s00198-013-2346-1
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1007/s00198-013-2377-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049259339
    241 https://doi.org/10.1007/s00198-013-2377-7
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1007/s00198-013-2571-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048776057
    244 https://doi.org/10.1007/s00198-013-2571-7
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1007/s00198-014-2697-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017715580
    247 https://doi.org/10.1007/s00198-014-2697-2
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1007/s00198-015-3083-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011444020
    250 https://doi.org/10.1007/s00198-015-3083-4
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1007/s11914-008-0003-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1033941038
    253 https://doi.org/10.1007/s11914-008-0003-y
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1007/s11914-011-0066-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1010310284
    256 https://doi.org/10.1007/s11914-011-0066-z
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1007/s40618-014-0167-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050389628
    259 https://doi.org/10.1007/s40618-014-0167-5
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/nrrheum.2012.143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026279140
    262 https://doi.org/10.1038/nrrheum.2012.143
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/sj.ejcn.1602657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042466608
    265 https://doi.org/10.1038/sj.ejcn.1602657
    266 rdf:type schema:CreativeWork
    267 grid-institutes:grid.264381.a schema:alternateName Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea
    268 Division of Rheumatology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, 03181, Seoul, Republic of Korea
    269 schema:name Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    270 Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea
    271 Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Samsung Main Building B2, 67 Sejong-daero, Jung-gu, 04514, Seoul, Republic of Korea
    272 Division of Rheumatology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, 03181, Seoul, Republic of Korea
    273 rdf:type schema:Organization
    274 grid-institutes:grid.414964.a schema:alternateName Center for Health Promotion, Samsung Medical Center, Seoul, Republic of Korea
    275 schema:name Center for Health Promotion, Samsung Medical Center, Seoul, Republic of Korea
    276 rdf:type schema:Organization
    277 grid-institutes:grid.415671.0 schema:alternateName Department of Internal Medicine, National Police Hospital, Seoul, Republic of Korea
    278 schema:name Department of Internal Medicine, National Police Hospital, Seoul, Republic of Korea
    279 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...