Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-05-24

AUTHORS

Noriko Koitaya, Mariko Sekiguchi, Yuko Tousen, Yoriko Nishide, Akemi Morita, Jun Yamauchi, Yuko Gando, Motohiko Miyachi, Mami Aoki, Miho Komatsu, Fumiko Watanabe, Koji Morishita, Yoshiko Ishimi

ABSTRACT

Menaquinone-4 (MK-4) administered at a pharmacological dosage of 45 mg/day has been used for the treatment of osteoporosis in Japan. However, it is not known whether a lower dose of MK-4 supplementation is beneficial for bone health in healthy postmenopausal women. The aim of this study was to examine the long-term effects of 1.5-mg daily supplementation of MK-4 on the various markers of bone turnover and bone mineral density (BMD). The study was performed as a randomized, double-blind, placebo-controlled trial. The participants (aged 50–65 years) were randomly assigned to one of two groups according to the MK-4 dose received: the placebo-control group (n = 24) and the 1.5-mg MK-4 group (n = 24). The baseline concentrations of undercarboxylated osteocalcin (ucOC) were high in both groups (>5.1 ng/ml). After 6 and 12 months, the serum ucOC concentrations were significantly lower in the MK-4 group than in the control group. In the control group, there was no significant change in serum pentosidine concentrations. However, in the MK-4 group, the concentration of pentosidine at 6 and 12 months was significantly lower than that at baseline. The forearm BMD was significantly lower after 12 months than at 6 months in the control group. However, there was no significant decrease in BMD in the MK-4 group during the study period. These results suggest that low-dose MK-4 supplementation for 6–12 months improved bone quality in the postmenopausal Japanese women by decreasing the serum ucOC and pentosidine concentrations, without any substantial adverse effects. More... »

PAGES

142-150

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00774-013-0472-7

DOI

http://dx.doi.org/10.1007/s00774-013-0472-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045968183

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23702931


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30 schema:description Menaquinone-4 (MK-4) administered at a pharmacological dosage of 45 mg/day has been used for the treatment of osteoporosis in Japan. However, it is not known whether a lower dose of MK-4 supplementation is beneficial for bone health in healthy postmenopausal women. The aim of this study was to examine the long-term effects of 1.5-mg daily supplementation of MK-4 on the various markers of bone turnover and bone mineral density (BMD). The study was performed as a randomized, double-blind, placebo-controlled trial. The participants (aged 50–65 years) were randomly assigned to one of two groups according to the MK-4 dose received: the placebo-control group (n = 24) and the 1.5-mg MK-4 group (n = 24). The baseline concentrations of undercarboxylated osteocalcin (ucOC) were high in both groups (>5.1 ng/ml). After 6 and 12 months, the serum ucOC concentrations were significantly lower in the MK-4 group than in the control group. In the control group, there was no significant change in serum pentosidine concentrations. However, in the MK-4 group, the concentration of pentosidine at 6 and 12 months was significantly lower than that at baseline. The forearm BMD was significantly lower after 12 months than at 6 months in the control group. However, there was no significant decrease in BMD in the MK-4 group during the study period. These results suggest that low-dose MK-4 supplementation for 6–12 months improved bone quality in the postmenopausal Japanese women by decreasing the serum ucOC and pentosidine concentrations, without any substantial adverse effects.
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39 K2 supplementation
40 MK-4
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42 MK-4 supplementation
43 adverse effects
44 aim
45 baseline
46 baseline concentrations
47 bone health
48 bone loss
49 bone metabolism
50 bone mineral density
51 bone quality
52 bone turnover
53 changes
54 concentration
55 concentration of pentosidine
56 control group
57 daily supplementation
58 days
59 decrease
60 density
61 dosage
62 dose
63 effect
64 forearm bone mineral density
65 group
66 health
67 healthy postmenopausal women
68 long-term effects
69 loss
70 low dose
71 markers
72 menaquinone-4
73 metabolism
74 mineral density
75 months
76 osteocalcin
77 osteoporosis
78 participants
79 pentosidine
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85 postmenopausal Japanese women
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87 quality
88 results
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