Ontology type: schema:ScholarlyArticle
2010-11
AUTHORSStergios A. Polyzos, Athanasios D. Anastasilakis, Ioannis Litsas, Zoe Efstathiadou, Marina Kita, Georgios Arsos, Efstratios Moralidis, Athanasios Papatheodorou, Evangelos Terpos
ABSTRACTJuvenile Paget's disease (JPD) is a rare, autosomal recessive osteopathy. Although it has phenotypic overlap with Paget's disease of bone (PDB), it is probably a distinct entity. Because of its rarity, optimal disease management has not yet been established by randomized controlled trials. However, clinical, biochemical, and radiographic improvement has been reported after treatment with antiresorptive agents, including calcitonin and bisphosphonates (BPs). Compared with other BPs, zoledronic acid (ZOL) has a higher affinity to bone mineral and is a stronger inhibitor of the enzyme farnesyl pyrophosphate synthase (the main target of nitrogen-containing BPs), properties that explain the prolonged effect of ZOL on bone turnover and render it a therapeutic option for JPD, similar to PDB. We describe hereby, for the first time in the literature, the case of a patient with JPD who developed severe hypocalcemia and secondary hyperparathyroidism following effective treatment with ZOL. More... »
PAGES706-712
http://scigraph.springernature.com/pub.10.1007/s00774-010-0198-8
DOIhttp://dx.doi.org/10.1007/s00774-010-0198-8
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1007886839
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/20533067
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bone Density Conservation Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bone and Bones",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Diphosphonates",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Monitoring",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hyperparathyroidism, Secondary",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hypocalcemia",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Imidazoles",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Osteitis Deformans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Radiography",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Zoledronic Acid",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"name": [
"Department of Endocrinology, Ippokration General Hospital, 13 Simou Lianidi, 551 34, Thessaloniki, Greece"
],
"type": "Organization"
},
"familyName": "Polyzos",
"givenName": "Stergios A.",
"id": "sg:person.0720405206.87",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720405206.87"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "424 General Military Hospital",
"id": "https://www.grid.ac/institutes/grid.413162.3",
"name": [
"Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Greece"
],
"type": "Organization"
},
"familyName": "Anastasilakis",
"givenName": "Athanasios D.",
"id": "sg:person.0665320523.06",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665320523.06"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Endocrinology, Ippokration General Hospital, 13 Simou Lianidi, 551 34, Thessaloniki, Greece"
],
"type": "Organization"
},
"familyName": "Litsas",
"givenName": "Ioannis",
"id": "sg:person.01145254441.25",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145254441.25"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Endocrinology, Ippokration General Hospital, 13 Simou Lianidi, 551 34, Thessaloniki, Greece"
],
"type": "Organization"
},
"familyName": "Efstathiadou",
"givenName": "Zoe",
"id": "sg:person.01105712243.88",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105712243.88"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Endocrinology, Ippokration General Hospital, 13 Simou Lianidi, 551 34, Thessaloniki, Greece"
],
"type": "Organization"
},
"familyName": "Kita",
"givenName": "Marina",
"id": "sg:person.0753461143.67",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753461143.67"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Aristotle University of Thessaloniki",
"id": "https://www.grid.ac/institutes/grid.4793.9",
"name": [
"Department of Nuclear Medicine, Ippokration General Hospital, Aristotle University, Thessaloniki, Greece"
],
"type": "Organization"
},
"familyName": "Arsos",
"givenName": "Georgios",
"id": "sg:person.01070072342.28",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070072342.28"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Aristotle University of Thessaloniki",
"id": "https://www.grid.ac/institutes/grid.4793.9",
"name": [
"Department of Nuclear Medicine, Ippokration General Hospital, Aristotle University, Thessaloniki, Greece"
],
"type": "Organization"
},
"familyName": "Moralidis",
"givenName": "Efstratios",
"id": "sg:person.01167453050.88",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167453050.88"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hellenic Airforce General Hospital",
"id": "https://www.grid.ac/institutes/grid.413129.c",
"name": [
"Department of Medical Research, 251 General Airforce Hospital, Athens, Greece"
],
"type": "Organization"
},
"familyName": "Papatheodorou",
"givenName": "Athanasios",
"id": "sg:person.0764402627.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764402627.02"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "National and Kapodistrian University of Athens",
"id": "https://www.grid.ac/institutes/grid.5216.0",
"name": [
"Department of Clinical Therapeutics, University of Athens School of Medicine, Athens, Greece"
],
"type": "Organization"
},
"familyName": "Terpos",
"givenName": "Evangelos",
"id": "sg:person.01243746204.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243746204.24"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1359/jbmr.06s204",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006097337"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s8756-3282(98)00163-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014262911"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/hmg/11.18.2119",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015873036"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa044241",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016135081"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bone.2006.04.032",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017980427"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1359/jbmr.040127",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019091210"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jbmr.5650110206",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020983086"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jbmr.5650110206",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020983086"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa013096",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025418560"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1515/jpem.2000.13.2.217",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027274616"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1586/eem.09.35",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030017959"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1586/eem.09.35",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030017959"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00774-008-0852-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033863898",
"https://doi.org/10.1007/s00774-008-0852-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00774-008-0852-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033863898",
"https://doi.org/10.1007/s00774-008-0852-6"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1359/jbmr.2001.16.9.1719",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035442623"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa050893",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039425874"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bone.2005.05.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041542072"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.berh.2007.11.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041883207"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/07315724.2003.10719287",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043273084"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00520-009-0704-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043496933",
"https://doi.org/10.1007/s00520-009-0704-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00520-009-0704-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043496933",
"https://doi.org/10.1007/s00520-009-0704-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00520-009-0704-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043496933",
"https://doi.org/10.1007/s00520-009-0704-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00198-008-0629-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048245372",
"https://doi.org/10.1007/s00198-008-0629-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00198-008-0629-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048245372",
"https://doi.org/10.1007/s00198-008-0629-8"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jbmr.5650090519",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050295220"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jbmr.5650090519",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050295220"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bone.2004.03.013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052239074"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1055/s-0029-1233491",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1057203198"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/154405910708601102",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064058449"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/154405910708601102",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064058449"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.2006-0479",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064289181"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1259/0007-1285-47-553-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064550126"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.14310/horm.2002.1226",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1067262245",
"https://doi.org/10.14310/horm.2002.1226"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077061543",
"type": "CreativeWork"
}
],
"datePublished": "2010-11",
"datePublishedReg": "2010-11-01",
"description": "Juvenile Paget's disease (JPD) is a rare, autosomal recessive osteopathy. Although it has phenotypic overlap with Paget's disease of bone (PDB), it is probably a distinct entity. Because of its rarity, optimal disease management has not yet been established by randomized controlled trials. However, clinical, biochemical, and radiographic improvement has been reported after treatment with antiresorptive agents, including calcitonin and bisphosphonates (BPs). Compared with other BPs, zoledronic acid (ZOL) has a higher affinity to bone mineral and is a stronger inhibitor of the enzyme farnesyl pyrophosphate synthase (the main target of nitrogen-containing BPs), properties that explain the prolonged effect of ZOL on bone turnover and render it a therapeutic option for JPD, similar to PDB. We describe hereby, for the first time in the literature, the case of a patient with JPD who developed severe hypocalcemia and secondary hyperparathyroidism following effective treatment with ZOL.",
"genre": "research_article",
"id": "sg:pub.10.1007/s00774-010-0198-8",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1312216",
"issn": [
"0914-8779",
"1435-5604"
],
"name": "Journal of Bone and Mineral Metabolism",
"type": "Periodical"
},
{
"issueNumber": "6",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "28"
}
],
"name": "Profound hypocalcemia following effective response to zoledronic acid treatment in a patient with juvenile Paget\u2019s disease",
"pagination": "706-712",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"2591e7915e1d154358aae77590ba861cc1e1da777df9782b80de141379682fa2"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"20533067"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9436705"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00774-010-0198-8"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1007886839"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00774-010-0198-8",
"https://app.dimensions.ai/details/publication/pub.1007886839"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T10:31",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113650_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007%2Fs00774-010-0198-8"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00774-010-0198-8'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00774-010-0198-8'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00774-010-0198-8'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00774-010-0198-8'
This table displays all metadata directly associated to this object as RDF triples.
275 TRIPLES
21 PREDICATES
68 URIs
34 LITERALS
22 BLANK NODES