Serum homocysteine, folate and vitamin B12 in patients with Paget’s disease of bone: the effect of zoledronic acid View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-05

AUTHORS

Stergios A. Polyzos, Athanasios D. Anastasilakis, Zoe Efstathiadou, Ioannis Litsas, Marina Kita, Athanasios Panagiotou, Athanasios Papatheodorou, Georgios Arsos, Efstratios Moralidis, Georgios Barmpalios, Efthimia Zafeiriadou, Efthimia Triantafillidou, Eleni Makrigiannaki, Evangelos Terpos

ABSTRACT

High serum homocysteine (HCY) and indirectly deficiency of folate and/or vitamin B(12) stimulate bone resorption and adversely affect collagen cross-linking. The aim of this study was the evaluation of serum levels of HCY, folate and vitamin B(12) in patients with Paget's disease of bone (PDB) and the effect of zoledronic acid (ZOL) on their serum levels. Nine consecutive patients with polyostotic PDB (median age 66 years) received a single 5-mg ZOL infusion. Blood samples for HCY, folate, vitamin B(12), 25-hydroxyvitamin D (25-OH-D), total serum alkaline phosphatase (TSAP), bone-specific serum alkaline phosphatase (BSAP) and C-terminal cross-linking telopeptide of type I collagen (CTX) were obtained at baseline and 3, 6 and 12 months after ZOL infusion. Twelve age-, gender- and BMI-matched healthy individuals were recruited for the control group at baseline assessment. Patients with PDB had significantly higher serum HCY (p = 0.028), folate (p < 0.001) and bone markers [TSAP (p < 0.001), BSAP (p < 0.001) and CTX (p < 0.001)] compared with the control group at baseline. In the pagetic group, serum HCY significantly decreased 3 months after ZOL infusion and remained essentially unchanged up to the end of the study (p = 0.005). Serum vitamin B(12) and folate remained unaffected throughout the study. Our data suggest that serum HCY levels are increased in patients with PDB. A single ZOL infusion results in a decrease in HCY levels that might represent another mechanism for the reduction of the activity of PDB achieved by ZOL. More... »

PAGES

314-319

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00774-009-0131-1

DOI

http://dx.doi.org/10.1007/s00774-009-0131-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013229359

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19841860


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