Choice of study phenotype in osteoporosis genetic research View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-02-03

AUTHORS

Yuan Chen, Hui Shen, Fang Yang, Peng-Yuan Liu, Nelson Tang, Robert R. Recker, Hong-Wen Deng

ABSTRACT

Osteoporosis is a common disease characterized by compromised bone strength predisposing a person to an increased risk of osteoporotic fracture (OF). Recently, extensive efforts have been made to identify candidate genes underlying osteoporosis by the use of surrogate phenotypes, such as bone mineral density (BMD) and bone geometry. Among them, BMD is a suitable choice if we aim to classify the role of biological pathways for bone strength and to understand the bone conditions in the development of osteoporosis. However, evidences show that the genetic correlation between BMD and OF is very limited. In this review, we are mainly concerned with an important issue, i.e., phenotype choice in osteoporosis genetic research. For clarity, we address this issue with several arguments, and comments are made on most representative literature. More... »

PAGES

121-126

References to SciGraph publications

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  • 2002-01-30. A comprehensive linkage analysis for myocardial infarction and its related risk factors in NATURE GENETICS
  • 2004-01-22. Can geometry-based parameters from pQCT and material parameters from quantitative ultrasound (QUS) improve the prediction of radial bone strength over that by bone mass (DXA)? in OSTEOPOROSIS INTERNATIONAL
  • 2005-02. Bigger is better, but it's not just size that counts: The estrogen receptor gene and osteoporosis in BONEKEY REPORTS
  • 2002-07. Biochemical Indices of Bone Turnover and the Assessment of Fracture Probability in OSTEOPOROSIS INTERNATIONAL
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  • 2003-09. pQCT bone strength index may serve as a better predictor than bone mineral density for long bone breaking strength in JOURNAL OF BONE AND MINERAL METABOLISM
  • 2004-01. Bone mineral density in elderly Chinese: effects of age, sex, weight, height, and body mass index in JOURNAL OF BONE AND MINERAL METABOLISM
  • 2007-05-30. Searching for genes underlying susceptibility to osteoporotic fracture: current progress and future prospect in OSTEOPOROSIS INTERNATIONAL
  • 2007-04-25. Genetic determination in onset age of wrist fracture in JOURNAL OF HUMAN GENETICS
  • 1999-08. Family History of Appendicular Fracture and Risk of Osteoporosis: A Population-Based Study in OSTEOPOROSIS INTERNATIONAL
  • 1998-08. Comparative Assessment of Bone Mineral Measurements Using Dual X-ray Absorptiometry and Peripheral Quantitative Computed Tomography in OSTEOPOROSIS INTERNATIONAL
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    URI

    http://scigraph.springernature.com/pub.10.1007/s00774-008-0020-z

    DOI

    http://dx.doi.org/10.1007/s00774-008-0020-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044856623

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19184673


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