Stellenwert der isolierten Extremitätenperfusion bei Sarkomen View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-03

AUTHORS

L. E. Podleska, F. Farzaliyev, G. Täger

ABSTRACT

Die isolierte Extremitätenperfusion mit Tumornekrosefaktor-α (TNF-α) und Melphalan (TM-ILP [ILP: „isolated limb perfusion“]) ist eines der wirksamsten Therapieverfahren zur neoadjuvanten Therapie von nicht resektablen Weichgewebesarkomen der Extremitäten. Diese Übersichtsarbeit beschreibt die Zusammenhänge und Wirkungsweise der TM-ILP, v. a. im Hinblick auf die Einhaltung der Sicherheitsabstände und die Möglichkeiten der TM-ILP, diese durch Devitalisierung der Tumorzellen in den Randbereichen bzw. den zukünftigen Resektionsrändern zu verbessern. Es wurden eine Recherche und Auswertung aktueller Literatur durchgeführt. Durch die Vorbehandlung mittels TM-ILP kann eine sonst notwendige Amputation in 80 % der Fälle vermieden werden. Im Rahmen eines kurativen, multimodalen Therapieansatzes kann der Tumor nach der initialen TM-ILP 6–8 Wochen später mit knappen Sicherheitsabständen unter Erhalt der Extremität entfernt werden. Auch in palliativer Therapieintention kann die TM-ILP Anwendung finden. Hierdurch kann, insbesondere in Kombination mit einer anschließenden systemischen Chemotherapie, ein längerfristiger Wachstumsarrest des Tumors erreicht werden. In Kombination mit einer anschließenden Strahlentherapie kann dieser Effekt noch verstärkt werden. Trotz der bestehenden Amputationsindikation zeigen Patienten nach ILP hervorragende Lebensqualität, die auch im längerfristigen Verlauf konstant bleibt. More... »

PAGES

216-223

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  • Journal

    TITLE

    Der Onkologe

    ISSUE

    3

    VOLUME

    24

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00761-017-0328-1

    DOI

    http://dx.doi.org/10.1007/s00761-017-0328-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1100619542


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