Molekulare Pathologie des kolorektalen Karzinoms View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-09

AUTHORS

Jens H.L. Neumann, Andreas Jung, Thomas Kirchner

ABSTRACT

In den letzten Jahren konnten beim kolorektalen Karzinom (KRK) mehrere prädiktive und prognostische Biomarker etabliert werden. Der RAS-Mutationsstatus ist ein in der täglichen Routine breit angewendeter prädiktiver Biomarker für eine Therapie mit Epidermal-Growth-Factor-Receptor(EGFR)-Inhibitoren. Eine BRAF-Mutation besitzt in diesem Kontext hingegen keine prädiktive Aussagekraft. Der Nachweis einer hochgradigen Mikrosatelliteninstabilität (MSI-H) ist prädiktiv für das Ansprechen auf eine 5-Fluoruracil-Monotherapie. Prognostische Biomarker beim KRK sind der MSI-Status sowie der Nachweis einer BRAF-Mutation. Nach der aktuellen WHO-Klassifikation werden wenig und undifferenzierte KRK sowie MSI-assoziierte morphologische Sonderformen anhand des MSI-Status molekular graduiert. Der Nachweis einer BRAF-Mutation vor dem Hintergrund einer Mikrosatellitenstabilität (MSS) ist mit einer sehr schlechten Prognose assoziiert und stellt somit den aggressivsten molekularen Subtyp des KRK dar. Für die Abklärung eines begründeten Verdachts auf eine Assoziation eines KRK mit einem hereditären nichtpolipösen kolorektalen Karzinom (HNPCC-Syndrom) wird aktuell eine immunhistochemische und molekularpathologische Stufendiagnostik empfohlen. More... »

PAGES

140-148

References to SciGraph publications

Journal

TITLE

Wiener klinisches Magazin

ISSUE

4

VOLUME

18

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00740-015-0061-6

DOI

http://dx.doi.org/10.1007/s00740-015-0061-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010998230


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00740-015-0061-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00740-015-0061-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00740-015-0061-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00740-015-0061-6'


 

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