Efficient synthesis of amino acids capped gold nanoparticles from easily reducible aryldiazonium tetrachloroaurate(III) salts for cellular uptake study View Full Text


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Article Info

DATE

2020-06-30

AUTHORS

Mehavesh K. Hameed, Islam M. Ahmady, Changseok Han, Ahmed A. Mohamed

ABSTRACT

Biomimetic synthesis of gold nanoparticles (GNPs) is critical in biomedical applications. Gold bioconjugates were fabricated by capping the water-dispersible gold-carbon nanoparticles with tyrosine, tryptophan and cysteine amino acids. Incubation of the water-soluble and easily reducible aryldiazonium gold(III) salt [HOOC-4-C6H4N≡N]AuCl4 with amino acids at room temperature formed a purple color over a few minutes with tryptophan and tyrosine and over two hours with cysteine. Rarely that cysteine is capable of reducing gold(III) precursors; however, a cysteine capped gold bioconjugate was synthesized and characterized in this study. Capping GNPs with amino acids was confirmed by high resolution transmission electron microscopy (TEM) and agarose gel electrophoresis. Depending on the amino acid, synthesized particles size was 27.2 ± 5.4 nm, 14.6 ± 7.7 nm and 8.6 ± 2.6 nm for tyrosine, tryptophan and cysteine, respectively. The amino acids capped GNPs showed negligible cytotoxicity to human dermal normal fibroblast cell lines. The highly water dispersible bioconjugates were studied for in vitro cellular uptake by HeLa cancer cells using confocal laser scan microscopy (CLSM) after being labelled with FITC (GNPs-COOH-FITC) and the nuclei were counter stained with DAPI fluorescent dyes. The biomimetic route for the synthesis of the amino acids reduced gold-carbon nanoparticles will benefit the applications in biomedical devices and biosensors. More... »

PAGES

941-953

References to SciGraph publications

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  • 2019-09-28. Light-driven formation of gold/tryptophan nanoparticles in APPLIED NANOSCIENCE
  • 2010-02-11. Study of tryptophan assisted synthesis of gold nanoparticles by combining UV–Vis, fluorescence, and SERS spectroscopy in JOURNAL OF NANOPARTICLE RESEARCH
  • 2019-07-06. Gold nanoparticles stabilized with four kinds of amino acid-derived carbon dots for colorimetric and visual discrimination of proteins and microorganisms in MICROCHIMICA ACTA
  • 2003-04-01. Identification of oxidation products and free radicals of tryptophan by mass spectrometry in JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
  • 2013-07-23. Preparation and Characterization of Gold Nanoparticles with Amino Acids, Examination of Their Stability in INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
  • 2015-07-21. Tyrosine- and tryptophan-coated gold nanoparticles inhibit amyloid aggregation of insulin in AMINO ACIDS
  • 2013-12-31. Comparison of amino acids interaction with gold nanoparticle in AMINO ACIDS
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  • 2019-07-10. Simultaneous recognition of cysteine and cytosine using thiophene-based organic nanoparticles decorated with Au NPs and bio-imaging of cells in PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
  • 2010-04-06. Toxicity and cellular uptake of gold nanoparticles: what we have learned so far? in JOURNAL OF NANOPARTICLE RESEARCH
  • 2016-02-24. The pH-Dependent Stucture and Properties of Au and Ag Nanoparticles Produced by Tryptophan Reduction in NANOSCALE RESEARCH LETTERS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00726-020-02862-z

    DOI

    http://dx.doi.org/10.1007/s00726-020-02862-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1128873256

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/32607864


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