Mass spectrometric studies on the interaction of cisplatin and insulin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-04

AUTHORS

Jing Li, Lei Yue, Yaqin Liu, Xinchi Yin, Qi Yin, Yuanjiang Pan, Lirong Yang

ABSTRACT

The interaction of antitumor drug, cisplatin (cis-[PtCl2(NH3)2], CDDP) with insulin from porcine pancreas has been investigated by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and high resolution hybrid ion trap/time-of-flight mass spectrometry (MALIDI-TOF/TOF-MS and ESI-IT/TOF MS). The MALDI-TOF/TOF-MS results demonstrated that the presence of cisplatin complex resulted in the reduction of the disulfide bond in porcine pancreas after the incubations of the two substances were performed in vitro. It indicated that the presence of cisplatin would destroy the native configuration of insulin, which may lead to the inactivation of insulin. High resolution mass values and the characteristic isotopic pattern of the platinated insulin ions allowed the analysis of platinated mono-, di- and triadducts of cisplatin and insulin in the incubations under different conditions. The laser-induced dissociation of the monoadduct obtained in MALDI source was carried out and one platinum was found to bind to insulin B chain was determined. The platinum binding sites were further identified to be the N terminus (B chain), cysteine 7 (B chain) and cysteine 19 (B chain) residues by electrospray ionization tandem mass spectrometry. The identification of the interaction between insulin and cisplatin broadens the horizon of the knowledge in the interaction of the proteins and metallodrugs. More... »

PAGES

1033-1043

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00726-015-2159-y

    DOI

    http://dx.doi.org/10.1007/s00726-015-2159-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1013849534

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26724920


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