The role of leucine and its metabolites in protein and energy metabolism View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-08-09

AUTHORS

Yehui Duan, Fengna Li, Yinghui Li, Yulong Tang, Xiangfeng Kong, Zemeng Feng, Tracy G. Anthony, Malcolm Watford, Yongqing Hou, Guoyao Wu, Yulong Yin

ABSTRACT

Leucine (Leu) is a nutritionally essential branched-chain amino acid (BCAA) in animal nutrition. It is usually one of the most abundant amino acids in high-quality protein foods. Leu increases protein synthesis through activation of the mammalian target of rapamycin (mTOR) signaling pathway in skeletal muscle, adipose tissue and placental cells. Leu promotes energy metabolism (glucose uptake, mitochondrial biogenesis, and fatty acid oxidation) to provide energy for protein synthesis, while inhibiting protein degradation. Approximately 80 % of Leu is normally used for protein synthesis, while the remainder is converted to α-ketoisocaproate (α-KIC) and β-hydroxy-β-methylbutyrate (HMB) in skeletal muscle. Therefore, it has been hypothesized that some of the functions of Leu are modulated by its metabolites. Both α-KIC and HMB have recently received considerable attention as nutritional supplements used to increase protein synthesis, inhibit protein degradation, and regulate energy homeostasis in a variety of in vitro and in vivo models. Leu and its metabolites hold great promise to enhance the growth and health of animals (including humans, birds and fish). More... »

PAGES

41-51

References to SciGraph publications

  • 2011-02-23. β-Hydroxy-β-methylbutyrate (HMβ) supplementation stimulates skeletal muscle hypertrophy in rats via the mTOR pathway in NUTRITION & METABOLISM
  • 2015-01-01. l-Leucine and NO-mediated cardiovascular function in AMINO ACIDS
  • 2013-09-22. Beta-hydroxy-beta-methylbutyrate supplementation in health and disease: a systematic review of randomized trials in AMINO ACIDS
  • 2011-11-11. Metabolic and functional effects of beta-hydroxy-beta-methylbutyrate (HMB) supplementation in skeletal muscle in EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
  • 2015-02-21. Key mediators of intracellular amino acids signaling to mTORC1 activation in AMINO ACIDS
  • 2010-05-15. Supplementing l-leucine to a low-protein diet increases tissue protein synthesis in weanling pigs in AMINO ACIDS
  • 2014-11-20. Leucine is a major regulator of muscle protein synthesis in neonates in AMINO ACIDS
  • 2011-07-20. Leucine nutrition in animals and humans: mTOR signaling and beyond in AMINO ACIDS
  • 2014-06-14. Dietary requirements of synthesizable amino acids by animals: a paradigm shift in protein nutrition in JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
  • 2015-05-05. Dietary l-leucine supplementation enhances intestinal development in suckling piglets in AMINO ACIDS
  • 2010-08-20. Effects of β-hydroxy-β-methylbutyrate treatment in different types of skeletal muscle of intact and septic rats in JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
  • 2010-09-15. Composition of amino acids in feed ingredients for animal diets in AMINO ACIDS
  • 2000-08. β-Hydroxy-β-Methylbutyrate (HMB) Supplementation and the Promotion of Muscle Growth and Strength in SPORTS MEDICINE
  • 2012-12-18. Dietary requirements of “nutritionally non-essential amino acids” by animals and humans in AMINO ACIDS
  • 2012-06-17. Hormonal regulation of leucine catabolism in mammary epithelial cells in AMINO ACIDS
  • 2008-01-03. Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review in NUTRITION & METABOLISM
  • 2012-04-28. Regulation of leucine catabolism by metabolic fuels in mammary epithelial cells in AMINO ACIDS
  • 2011-08-23. Alpha-ketoglutarate inhibits glutamine degradation and enhances protein synthesis in intestinal porcine epithelial cells in AMINO ACIDS
  • 2009-11-01. Distinct anabolic signalling responses to amino acids in C2C12 skeletal muscle cells in AMINO ACIDS
  • 2009-06-05. Leucine modulation of mitochondrial mass and oxygen consumption in skeletal muscle cells and adipocytes in NUTRITION & METABOLISM
  • 2006-09-27. Suppression of myofibrillar proteolysis in chick skeletal muscles by α-ketoisocaproate in AMINO ACIDS
  • 2009-04-30. Mechanism of attenuation by β-hydroxy-β-methylbutyrate of muscle protein degradation induced by lipopolysaccharide in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2013-04-18. Functional amino acids in nutrition and health in AMINO ACIDS
  • 2014-05-08. Leucine facilitates the insulin-stimulated glucose uptake and insulin signaling in skeletal muscle cells: involving mTORC1 and mTORC2 in AMINO ACIDS
  • 2008-08-06. Dietary l-arginine supplementation increases muscle gain and reduces body fat mass in growing-finishing pigs in AMINO ACIDS
  • 2010-07-06. HMB supplementation: clinical and athletic performance-related effects and mechanisms of action in AMINO ACIDS
  • 1980-11. L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase in NATURE
  • 2013-06-04. Impacts of arginine nutrition on embryonic and fetal development in mammals in AMINO ACIDS
  • 2009-01-08. Glutamine, arginine, and leucine signaling in the intestine in AMINO ACIDS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00726-015-2067-1

    DOI

    http://dx.doi.org/10.1007/s00726-015-2067-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041340932

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26255285


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