Agmatine prevents the Ca2+-dependent induction of permeability transition in rat brain mitochondria View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-02

AUTHORS

V. Battaglia, S. Grancara, J. Satriano, S. Saccoccio, E. Agostinelli, A. Toninello

ABSTRACT

The arginine metabolite agmatine is able to protect brain mitochondria against the drop in energy capacity by the Ca(2+)-dependent induction of permeability transition (MPT) in rat brain mitochondria. At normal levels, the amine maintains the respiratory control index and ADP/O ratio and prevents mitochondrial colloid-osmotic swelling and any electrical potential (DeltaPsi) drop. MPT is due to oxidative stress induced by the interaction of Ca(2+) with the mitochondrial membrane, leading to the production of hydrogen peroxide and, subsequently, other reactive oxygen species (ROS) such as hydroxyl radicals. This production of ROS induces oxidation of sulfhydryl groups, in particular those of two critical cysteines, most probably located on adenine nucleotide translocase, and also oxidation of pyridine nucleotides, resulting in transition pore opening. The protective effect of agmatine is attributable to a scavenging effect on the most toxic ROS, i.e., the hydroxyl radical, thus preventing oxidative stress and consequent bioenergetic collapse. More... »

PAGES

431-437

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00726-009-0402-0

DOI

http://dx.doi.org/10.1007/s00726-009-0402-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019366973

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20012118


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0399", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Other Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Agmatine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Membrane Permeability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Potential, Mitochondrial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondrial Membranes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reactive Oxygen Species", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Department of Biological Chemistry, University of Padua, Viale G. Colombo, 3, 35121, Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Battaglia", 
        "givenName": "V.", 
        "id": "sg:person.01154072330.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154072330.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Department of Biological Chemistry, University of Padua, Viale G. Colombo, 3, 35121, Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grancara", 
        "givenName": "S.", 
        "id": "sg:person.01315700751.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315700751.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Diego", 
          "id": "https://www.grid.ac/institutes/grid.266100.3", 
          "name": [
            "Division of Nephrology-Hypertension, Department of Medicine, The Veterans Administration San Diego Healthcare System, University of California, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Satriano", 
        "givenName": "J.", 
        "id": "sg:person.016370553324.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016370553324.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Research Council", 
          "id": "https://www.grid.ac/institutes/grid.5326.2", 
          "name": [
            "Department of Biochemical Sciences, SAPIENZA, University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy", 
            "CNR, Biology and Molecular Pathology Institutes, Piazzale Aldo Moro 5, 00185, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saccoccio", 
        "givenName": "S.", 
        "id": "sg:person.01132011746.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132011746.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Research Council", 
          "id": "https://www.grid.ac/institutes/grid.5326.2", 
          "name": [
            "Department of Biochemical Sciences, SAPIENZA, University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy", 
            "CNR, Biology and Molecular Pathology Institutes, Piazzale Aldo Moro 5, 00185, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Agostinelli", 
        "givenName": "E.", 
        "id": "sg:person.0774335205.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774335205.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Department of Biological Chemistry, University of Padua, Viale G. Colombo, 3, 35121, Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Toninello", 
        "givenName": "A.", 
        "id": "sg:person.062340273.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.062340273.35"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1046/j.1471-4159.2000.0742201.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000482005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00726-007-0513-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000730243", 
          "https://doi.org/10.1007/s00726-007-0513-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00726-007-0513-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000730243", 
          "https://doi.org/10.1007/s00726-007-0513-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00726-007-0513-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000730243", 
          "https://doi.org/10.1007/s00726-007-0513-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00726-003-0030-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000837026", 
          "https://doi.org/10.1007/s00726-003-0030-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.19.11140", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001993853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00084.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004583850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0704153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008026083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20060003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008028097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20060003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008028097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj1700511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011924523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj1700511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011924523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.abb.2009.03.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013251675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1432-1327.1999.00126.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014931787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20041260", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015486149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20041260", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015486149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(69)90064-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017746004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-4157(95)00003-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018462172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00529.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020482435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbabio.2008.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026883443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/exnr.2001.7746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028474414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m502391200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030168794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m502391200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030168794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01868720", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030758084", 
          "https://doi.org/10.1007/bf01868720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01868720", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030758084", 
          "https://doi.org/10.1007/bf01868720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20011672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033047607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20011672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033047607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbamem.2007.01.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034327934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00726-004-0078-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039591710", 
          "https://doi.org/10.1007/s00726-004-0078-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00726-004-0078-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039591710", 
          "https://doi.org/10.1007/s00726-004-0078-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0076-6879(79)56029-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039696838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2006.07.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041011691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0076-6879(79)55066-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042351986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00726-009-0401-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044800674", 
          "https://doi.org/10.1007/s00726-009-0401-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00726-009-0401-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044800674", 
          "https://doi.org/10.1007/s00726-009-0401-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00726-009-0401-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044800674", 
          "https://doi.org/10.1007/s00726-009-0401-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.25.15313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045577606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.1996.67041761.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047448534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(73)80165-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050225396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0891-5849(98)00003-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053157542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00726-004-0114-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053567899", 
          "https://doi.org/10.1007/s00726-004-0114-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jb/mvh150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059745212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077547132", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-02", 
    "datePublishedReg": "2010-02-01", 
    "description": "The arginine metabolite agmatine is able to protect brain mitochondria against the drop in energy capacity by the Ca(2+)-dependent induction of permeability transition (MPT) in rat brain mitochondria. At normal levels, the amine maintains the respiratory control index and ADP/O ratio and prevents mitochondrial colloid-osmotic swelling and any electrical potential (DeltaPsi) drop. MPT is due to oxidative stress induced by the interaction of Ca(2+) with the mitochondrial membrane, leading to the production of hydrogen peroxide and, subsequently, other reactive oxygen species (ROS) such as hydroxyl radicals. This production of ROS induces oxidation of sulfhydryl groups, in particular those of two critical cysteines, most probably located on adenine nucleotide translocase, and also oxidation of pyridine nucleotides, resulting in transition pore opening. The protective effect of agmatine is attributable to a scavenging effect on the most toxic ROS, i.e., the hydroxyl radical, thus preventing oxidative stress and consequent bioenergetic collapse.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00726-009-0402-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1101866", 
        "issn": [
          "0939-4451", 
          "1438-2199"
        ], 
        "name": "Amino Acids", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "38"
      }
    ], 
    "name": "Agmatine prevents the Ca2+-dependent induction of permeability transition in rat brain mitochondria", 
    "pagination": "431-437", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5c47042584cfc80e0eaf5ab6d954ab923922495c4ba6a1c9faa72607cb4fac22"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20012118"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9200312"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00726-009-0402-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1019366973"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00726-009-0402-0", 
      "https://app.dimensions.ai/details/publication/pub.1019366973"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13096_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00726-009-0402-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00726-009-0402-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00726-009-0402-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00726-009-0402-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00726-009-0402-0'


 

This table displays all metadata directly associated to this object as RDF triples.

244 TRIPLES      21 PREDICATES      69 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00726-009-0402-0 schema:about N0c50e7c250904747bbec80ff9b5a3dc6
2 N1aca853d0dfa48c5b25258c641928374
3 N33027759c85b406fadaaa77d3db5ac34
4 N6e1fe20ec20c41578c7ea455a9698748
5 Na0b1a145ac08405996bdc3f371f9b30b
6 Na88ad6c196b44e84b413a60a17897956
7 Nafefc08ec2214affb39cc7b4c2c231d7
8 Nb499a3ddebdd49b2bc77f3a518ee8247
9 anzsrc-for:03
10 anzsrc-for:0399
11 schema:author Ne195c4706d834085b94e2d84bf0624a6
12 schema:citation sg:pub.10.1007/bf01868720
13 sg:pub.10.1007/s00726-003-0030-z
14 sg:pub.10.1007/s00726-004-0078-4
15 sg:pub.10.1007/s00726-004-0114-4
16 sg:pub.10.1007/s00726-007-0513-4
17 sg:pub.10.1007/s00726-009-0401-1
18 https://app.dimensions.ai/details/publication/pub.1077547132
19 https://doi.org/10.1006/exnr.2001.7746
20 https://doi.org/10.1016/0003-2697(69)90064-5
21 https://doi.org/10.1016/0014-5793(73)80165-6
22 https://doi.org/10.1016/0076-6879(79)55066-6
23 https://doi.org/10.1016/0076-6879(79)56029-7
24 https://doi.org/10.1016/0304-4157(95)00003-a
25 https://doi.org/10.1016/j.abb.2009.03.006
26 https://doi.org/10.1016/j.bbabio.2008.08.002
27 https://doi.org/10.1016/j.bbamem.2007.01.011
28 https://doi.org/10.1016/j.freeradbiomed.2006.07.008
29 https://doi.org/10.1016/s0891-5849(98)00003-3
30 https://doi.org/10.1038/sj.bjp.0704153
31 https://doi.org/10.1042/bj1700511
32 https://doi.org/10.1042/bj20011672
33 https://doi.org/10.1042/bj20041260
34 https://doi.org/10.1042/bj20060003
35 https://doi.org/10.1046/j.1432-1327.1999.00126.x
36 https://doi.org/10.1046/j.1471-4159.1996.67041761.x
37 https://doi.org/10.1046/j.1471-4159.2000.0742201.x
38 https://doi.org/10.1073/pnas.95.19.11140
39 https://doi.org/10.1074/jbc.273.25.15313
40 https://doi.org/10.1074/jbc.m502391200
41 https://doi.org/10.1093/jb/mvh150
42 https://doi.org/10.1152/ajpcell.00084.2007
43 https://doi.org/10.1152/ajpcell.00529.2008
44 schema:datePublished 2010-02
45 schema:datePublishedReg 2010-02-01
46 schema:description The arginine metabolite agmatine is able to protect brain mitochondria against the drop in energy capacity by the Ca(2+)-dependent induction of permeability transition (MPT) in rat brain mitochondria. At normal levels, the amine maintains the respiratory control index and ADP/O ratio and prevents mitochondrial colloid-osmotic swelling and any electrical potential (DeltaPsi) drop. MPT is due to oxidative stress induced by the interaction of Ca(2+) with the mitochondrial membrane, leading to the production of hydrogen peroxide and, subsequently, other reactive oxygen species (ROS) such as hydroxyl radicals. This production of ROS induces oxidation of sulfhydryl groups, in particular those of two critical cysteines, most probably located on adenine nucleotide translocase, and also oxidation of pyridine nucleotides, resulting in transition pore opening. The protective effect of agmatine is attributable to a scavenging effect on the most toxic ROS, i.e., the hydroxyl radical, thus preventing oxidative stress and consequent bioenergetic collapse.
47 schema:genre research_article
48 schema:inLanguage en
49 schema:isAccessibleForFree false
50 schema:isPartOf N13242dc2ba1a4623b6ad12e6bfd90662
51 N530dafa0db8345238c3b6901e86c0d22
52 sg:journal.1101866
53 schema:name Agmatine prevents the Ca2+-dependent induction of permeability transition in rat brain mitochondria
54 schema:pagination 431-437
55 schema:productId N0b97f74c92314562b6932f2c563d6ec8
56 N2422e57b1d9d4449814f7d5c5540e024
57 N297f6fe9639d41dab523e6264d713eb6
58 Nceb5384d0eea4ed9841cd95b3249a312
59 Ne0ea19c4dca443f188d0654a340064a4
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019366973
61 https://doi.org/10.1007/s00726-009-0402-0
62 schema:sdDatePublished 2019-04-11T14:31
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher N3f54780119354074928ed80772d4e6dc
65 schema:url https://link.springer.com/10.1007%2Fs00726-009-0402-0
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N0b97f74c92314562b6932f2c563d6ec8 schema:name dimensions_id
70 schema:value pub.1019366973
71 rdf:type schema:PropertyValue
72 N0c50e7c250904747bbec80ff9b5a3dc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Cell Membrane Permeability
74 rdf:type schema:DefinedTerm
75 N117b8d3425b3454d8da7b2fc717f06dc rdf:first sg:person.0774335205.02
76 rdf:rest Nba386ddac959403b8efd3c77b9f79cb2
77 N13242dc2ba1a4623b6ad12e6bfd90662 schema:issueNumber 2
78 rdf:type schema:PublicationIssue
79 N1aca853d0dfa48c5b25258c641928374 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Rats
81 rdf:type schema:DefinedTerm
82 N2422e57b1d9d4449814f7d5c5540e024 schema:name readcube_id
83 schema:value 5c47042584cfc80e0eaf5ab6d954ab923922495c4ba6a1c9faa72607cb4fac22
84 rdf:type schema:PropertyValue
85 N297f6fe9639d41dab523e6264d713eb6 schema:name doi
86 schema:value 10.1007/s00726-009-0402-0
87 rdf:type schema:PropertyValue
88 N31c20fdfcc4f4186a649c794a7c28762 rdf:first sg:person.01132011746.11
89 rdf:rest N117b8d3425b3454d8da7b2fc717f06dc
90 N33027759c85b406fadaaa77d3db5ac34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Agmatine
92 rdf:type schema:DefinedTerm
93 N3f54780119354074928ed80772d4e6dc schema:name Springer Nature - SN SciGraph project
94 rdf:type schema:Organization
95 N530dafa0db8345238c3b6901e86c0d22 schema:volumeNumber 38
96 rdf:type schema:PublicationVolume
97 N6e1fe20ec20c41578c7ea455a9698748 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Reactive Oxygen Species
99 rdf:type schema:DefinedTerm
100 Na0b1a145ac08405996bdc3f371f9b30b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Mitochondrial Membranes
102 rdf:type schema:DefinedTerm
103 Na88ad6c196b44e84b413a60a17897956 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Calcium
105 rdf:type schema:DefinedTerm
106 Nafefc08ec2214affb39cc7b4c2c231d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Membrane Potential, Mitochondrial
108 rdf:type schema:DefinedTerm
109 Nb499a3ddebdd49b2bc77f3a518ee8247 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Animals
111 rdf:type schema:DefinedTerm
112 Nba386ddac959403b8efd3c77b9f79cb2 rdf:first sg:person.062340273.35
113 rdf:rest rdf:nil
114 Nceb5384d0eea4ed9841cd95b3249a312 schema:name nlm_unique_id
115 schema:value 9200312
116 rdf:type schema:PropertyValue
117 Ne0ea19c4dca443f188d0654a340064a4 schema:name pubmed_id
118 schema:value 20012118
119 rdf:type schema:PropertyValue
120 Ne195c4706d834085b94e2d84bf0624a6 rdf:first sg:person.01154072330.16
121 rdf:rest Nf01e7e49c6fa41808afe8d1013044e35
122 Ne8699f0bcf0d40978e55c5db2b3d71cd rdf:first sg:person.016370553324.21
123 rdf:rest N31c20fdfcc4f4186a649c794a7c28762
124 Nf01e7e49c6fa41808afe8d1013044e35 rdf:first sg:person.01315700751.48
125 rdf:rest Ne8699f0bcf0d40978e55c5db2b3d71cd
126 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
127 schema:name Chemical Sciences
128 rdf:type schema:DefinedTerm
129 anzsrc-for:0399 schema:inDefinedTermSet anzsrc-for:
130 schema:name Other Chemical Sciences
131 rdf:type schema:DefinedTerm
132 sg:journal.1101866 schema:issn 0939-4451
133 1438-2199
134 schema:name Amino Acids
135 rdf:type schema:Periodical
136 sg:person.01132011746.11 schema:affiliation https://www.grid.ac/institutes/grid.5326.2
137 schema:familyName Saccoccio
138 schema:givenName S.
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132011746.11
140 rdf:type schema:Person
141 sg:person.01154072330.16 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
142 schema:familyName Battaglia
143 schema:givenName V.
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154072330.16
145 rdf:type schema:Person
146 sg:person.01315700751.48 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
147 schema:familyName Grancara
148 schema:givenName S.
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315700751.48
150 rdf:type schema:Person
151 sg:person.016370553324.21 schema:affiliation https://www.grid.ac/institutes/grid.266100.3
152 schema:familyName Satriano
153 schema:givenName J.
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016370553324.21
155 rdf:type schema:Person
156 sg:person.062340273.35 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
157 schema:familyName Toninello
158 schema:givenName A.
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.062340273.35
160 rdf:type schema:Person
161 sg:person.0774335205.02 schema:affiliation https://www.grid.ac/institutes/grid.5326.2
162 schema:familyName Agostinelli
163 schema:givenName E.
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774335205.02
165 rdf:type schema:Person
166 sg:pub.10.1007/bf01868720 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030758084
167 https://doi.org/10.1007/bf01868720
168 rdf:type schema:CreativeWork
169 sg:pub.10.1007/s00726-003-0030-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1000837026
170 https://doi.org/10.1007/s00726-003-0030-z
171 rdf:type schema:CreativeWork
172 sg:pub.10.1007/s00726-004-0078-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039591710
173 https://doi.org/10.1007/s00726-004-0078-4
174 rdf:type schema:CreativeWork
175 sg:pub.10.1007/s00726-004-0114-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053567899
176 https://doi.org/10.1007/s00726-004-0114-4
177 rdf:type schema:CreativeWork
178 sg:pub.10.1007/s00726-007-0513-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000730243
179 https://doi.org/10.1007/s00726-007-0513-4
180 rdf:type schema:CreativeWork
181 sg:pub.10.1007/s00726-009-0401-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044800674
182 https://doi.org/10.1007/s00726-009-0401-1
183 rdf:type schema:CreativeWork
184 https://app.dimensions.ai/details/publication/pub.1077547132 schema:CreativeWork
185 https://doi.org/10.1006/exnr.2001.7746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028474414
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/0003-2697(69)90064-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017746004
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/0014-5793(73)80165-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050225396
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/0076-6879(79)55066-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042351986
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/0076-6879(79)56029-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039696838
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/0304-4157(95)00003-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1018462172
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/j.abb.2009.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013251675
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/j.bbabio.2008.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026883443
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/j.bbamem.2007.01.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034327934
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/j.freeradbiomed.2006.07.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041011691
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/s0891-5849(98)00003-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053157542
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1038/sj.bjp.0704153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008026083
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1042/bj1700511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011924523
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1042/bj20011672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033047607
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1042/bj20041260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015486149
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1042/bj20060003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008028097
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1046/j.1432-1327.1999.00126.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014931787
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1046/j.1471-4159.1996.67041761.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047448534
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1046/j.1471-4159.2000.0742201.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000482005
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1073/pnas.95.19.11140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001993853
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1074/jbc.273.25.15313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045577606
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1074/jbc.m502391200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030168794
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1093/jb/mvh150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059745212
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1152/ajpcell.00084.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004583850
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1152/ajpcell.00529.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020482435
234 rdf:type schema:CreativeWork
235 https://www.grid.ac/institutes/grid.266100.3 schema:alternateName University of California, San Diego
236 schema:name Division of Nephrology-Hypertension, Department of Medicine, The Veterans Administration San Diego Healthcare System, University of California, San Diego, CA, USA
237 rdf:type schema:Organization
238 https://www.grid.ac/institutes/grid.5326.2 schema:alternateName National Research Council
239 schema:name CNR, Biology and Molecular Pathology Institutes, Piazzale Aldo Moro 5, 00185, Rome, Italy
240 Department of Biochemical Sciences, SAPIENZA, University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy
241 rdf:type schema:Organization
242 https://www.grid.ac/institutes/grid.5608.b schema:alternateName University of Padua
243 schema:name Department of Biological Chemistry, University of Padua, Viale G. Colombo, 3, 35121, Padua, Italy
244 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...