Agmatine prevents the Ca2+-dependent induction of permeability transition in rat brain mitochondria View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-02

AUTHORS

V. Battaglia, S. Grancara, J. Satriano, S. Saccoccio, E. Agostinelli, A. Toninello

ABSTRACT

The arginine metabolite agmatine is able to protect brain mitochondria against the drop in energy capacity by the Ca(2+)-dependent induction of permeability transition (MPT) in rat brain mitochondria. At normal levels, the amine maintains the respiratory control index and ADP/O ratio and prevents mitochondrial colloid-osmotic swelling and any electrical potential (DeltaPsi) drop. MPT is due to oxidative stress induced by the interaction of Ca(2+) with the mitochondrial membrane, leading to the production of hydrogen peroxide and, subsequently, other reactive oxygen species (ROS) such as hydroxyl radicals. This production of ROS induces oxidation of sulfhydryl groups, in particular those of two critical cysteines, most probably located on adenine nucleotide translocase, and also oxidation of pyridine nucleotides, resulting in transition pore opening. The protective effect of agmatine is attributable to a scavenging effect on the most toxic ROS, i.e., the hydroxyl radical, thus preventing oxidative stress and consequent bioenergetic collapse. More... »

PAGES

431-437

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00726-009-0402-0

DOI

http://dx.doi.org/10.1007/s00726-009-0402-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019366973

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20012118


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