l-Proline transport into renal OK epithelial cells: a second renal proline transport system is induced by amino acid deprivation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-03

AUTHORS

A. Nickel, U. Klein, D. Weitz, H. Daniel

ABSTRACT

Influx of [(3)H]-L-proline into renal OK cells revealed that basal transport was mediated by the transporter SIT1. When cells were submitted for 8 h to amino acid deprivation, uptake of L-proline was now dominated by a low-affinity system with an apparent K (m) of 4.4 +/- 0.6 mM and a V (max) of 10.2 +/- 0.6 nmol/mg of protein/min operating in addition to the high-affinity SIT1 system with a K (m) of 0.12 +/- 0.01 mM and a V (max) of 0.28 +/- 0.04 nmol/mg of protein/min. The low- and high-affinity proline transporting systems were sensitive to inhibitors of JNK and PI-3 kinases, whereas a GSK-3 inhibitor affected only the upregulated transport system. Ion-replacement studies and experiments assessing substrate specificities for both systems provided strong evidence that SNAT2, that showed two- to threefold increased mRNA levels, is the responsible transporter mediating the increased proline influx under conditions of amino acid deprivation. More... »

PAGES

753-761

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00726-009-0280-5

DOI

http://dx.doi.org/10.1007/s00726-009-0280-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020565420

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19333719


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