Signal transduction and adaptive regulation through bacterial two-component systems: the Escherichia coli AtoSC paradigm View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-09

AUTHORS

Dimitrios A. Kyriakidis, Ekaterini Tiligada

ABSTRACT

Adaptive signal transduction within microbial cells involves a multi-faceted regulated phosphotransfer mechanism that comprises structural rearrangements of sensor histidine kinases upon ligand-binding and phosphorylation-induced conformational changes in response regulators of versatile two-component systems (TCS), arisen early in bacterial evolution. In Escherichia coli, cross-talk between the AtoS histidine kinase and the AtoC response regulator, forming the AtoSC TCS, through His --> Asp phosphotransfer, activates AtoC directly to induce atoDAEB operon expression, thus modulating diverse fundamental cellular processes such as short-chain fatty acid catabolism, poly-(R)-3-hydroxybutyrate biosynthesis and chemotaxis. Among the inducers hitherto identified, acetoacetate is the classical activator. The AtoSC TCS functional modulation by polyamines, histamine and Ca(2+), as well as the role of AtoC as transcriptional regulator, add new promising perspectives in the physiological significance and potential pharmacological exploitation of this TCS in cell proliferation, bacteria-host interactions, chemotaxis, and adaptation. More... »

PAGES

443-458

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00726-009-0241-z

    DOI

    http://dx.doi.org/10.1007/s00726-009-0241-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040418008

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19198978


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