The renal type H+/peptide symporter PEPT2: structure-affinity relationships View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-08

AUTHORS

A. Biegel, I. Knütter, B. Hartrodt, S. Gebauer, S. Theis, P. Luckner, G. Kottra, M. Rastetter, K. Zebisch, I. Thondorf, H. Daniel, K. Neubert, M. Brandsch

ABSTRACT

The H(+)/peptide cotransporter PEPT2 is expressed in a variety of organs including kidney, lung, brain, mammary gland, and eye. PEPT2 substrates are di- and tripeptides as well as peptidomimetics, such as beta-lactam antibiotics. Due to the presence of PEPT2 at the bronchial epithelium, the aerosolic administration of peptide-like drugs might play a major role in future treatment of various pulmonary and systemic diseases. Moreover, PEPT2 has a significant influence on the in vivo disposition and half-life time of peptide-like drugs within the body, particularly in kidney and brain. PEPT2 is known to have similar but not identical structural requirements for substrate recognition and transport compared to PEPT1, its intestinal counterpart. In this review we compiled available affinity constants of 352 compounds, measured at different mammalian tissues and expression systems and compare the data whenever possible with those of PEPT1. More... »

PAGES

137-156

References to SciGraph publications

  • 1997-12. Localization of peptide transporter in nuclei and lysosomes of the pancreas in JOURNAL OF GASTROINTESTINAL CANCER
  • 2000-09. Structural requirements for determining the substrate affinity of peptide transporters PEPT1 and PEPT2 in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1994-04. Expression cloning of a mammalian proton-coupled oligopeptide transporter in NATURE
  • 1998-01. Comparative molecular similarity indices analysis: CoMSIA in JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
  • 1999-01. Intestinal Transport of β-Lactam Antibiotics: Analysis of the Affinity at the H+/Peptide Symporter (PEPT1), the Uptake into Caco-2 Cell Monolayers and the Transepithelial Flux in PHARMACEUTICAL RESEARCH
  • 2000-05. Differential Recognition of ACE Inhibitors in Xenopus Laevis Oocytes Expressing Rat PEPT1 and PEPT2 in PHARMACEUTICAL RESEARCH
  • 1998-08. Tubular Localization and Tissue Distribution of Peptide Transporters in Rat Kidney in PHARMACEUTICAL RESEARCH
  • 1999-05. Competitive Inhibition of Glycylsarcosine Transport by Enalapril in Rabbit Renal Brush Border Membrane Vesicles: Interaction of ACE Inhibitors with High-Affinity H+/Peptide Symporter in PHARMACEUTICAL RESEARCH
  • 2005-08. Glycyl-l-Glutamine Disposition in Rat Choroid Plexus Epithelial Cells in Primary Culture: Role of PEPT2 in PHARMACEUTICAL RESEARCH
  • 2000-05. Structure and function of eukaryotic peptide transporters in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2002. Dipeptide Transporters in MEMBRANE TRANSPORTERS AS DRUG TARGETS
  • 2004-02. The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1987-12. Development of Dipeptide Transport in Rat Renal Brush Border Menbranes: Studies with Glycylsarcosine in PEDIATRIC RESEARCH
  • 1995-05. Oligopeptide transport by epithelial cells in THE JOURNAL OF MEMBRANE BIOLOGY
  • 1996-12. Function and Molecular Structure of Brush Border Membrane Peptide/H+ Symporters in THE JOURNAL OF MEMBRANE BIOLOGY
  • 2001-06. PEPT2-Mediated Uptake of Neuropeptides in Rat Choroid Plexus in PHARMACEUTICAL RESEARCH
  • 1999-03. Distribution of peptide transporter PEPT2 mRNA in the rat nervous system in BRAIN STRUCTURE AND FUNCTION
  • 2001-10. Yeast – a panacea for the structure–function analysis of membrane proteins? in CURRENT GENETICS
  • 2003-09. Preliminary Investigation into the Expression of Proton-Coupled Oligopeptide Transporters in Neural Retina and Retinal Pigment Epithelium (RPE): Lack of Functional Activity in RPE Plasma Membranes in PHARMACEUTICAL RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00726-006-0331-0

    DOI

    http://dx.doi.org/10.1007/s00726-006-0331-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040385678

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16868651


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