Determinants for Optimal Enhancement in Ex Situ DNP Experiments View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-08

AUTHORS

A.-H. Emwas, M. Saunders, C. Ludwig, U. L. Günther

ABSTRACT

.Dynamic nuclear polarization (DNP) is a potent method to enhance the sensitivity of nuclear magnetic resonance (NMR) signals. In a recent implementation of DNP, samples are polarized at low temperature in a glassy state followed by dissolution with hot solvent and transfer to an NMR magnet (J.H. Ardenkjaer-Larsen, B. Fridlund, A. Gram, G. Hansson, L. Hansson, M.H. Lerche, R. Servin, M. Thaning, K. Golman: Proc. Natl. Acad. Sci. USA 100, 10158, 2003). Although enormous polarizations in the order of tens of thousands were reported, such enhancements were only obtained for very few molecules. Here we have polarized a range of small molecules in order to identify determinants of polarizability. The key factors include functional groups which allow for a good contact to the radical and substances with long longitudinal relaxation times T1. We also observe that methyl groups play a particularly interesting role in 13C-DNP-NMR spectra taken at low temperature. More... »

PAGES

483-494

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00723-008-0120-x

DOI

http://dx.doi.org/10.1007/s00723-008-0120-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019249575


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0304", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medicinal and Biomolecular Chemistry", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, UK", 
          "id": "http://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Emwas", 
        "givenName": "A.-H.", 
        "id": "sg:person.011577166122.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011577166122.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, UK", 
          "id": "http://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saunders", 
        "givenName": "M.", 
        "id": "sg:person.0652127343.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652127343.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, UK", 
          "id": "http://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ludwig", 
        "givenName": "C.", 
        "id": "sg:person.01112544071.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112544071.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, UK", 
          "id": "http://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "G\u00fcnther", 
        "givenName": "U. L.", 
        "id": "sg:person.0733543446.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733543446.54"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2008-08", 
    "datePublishedReg": "2008-08-01", 
    "description": "Abstract.Dynamic nuclear polarization (DNP) is a potent method to enhance the sensitivity of nuclear magnetic resonance (NMR) signals. In a recent implementation of DNP, samples are polarized at low temperature in a glassy state followed by dissolution with hot solvent and transfer to an NMR magnet (J.H. Ardenkjaer-Larsen, B. Fridlund, A. Gram, G. Hansson, L. Hansson, M.H. Lerche, R. Servin, M. Thaning, K. Golman: Proc. Natl. Acad. Sci. USA 100, 10158, 2003). Although enormous polarizations in the order of tens of thousands were reported, such enhancements were only obtained for very few molecules. Here we have polarized a range of small molecules in order to identify determinants of polarizability. The key factors include functional groups which allow for a good contact to the radical and substances with long longitudinal relaxation times T1. We also observe that methyl groups play a particularly interesting role in 13C-DNP-NMR spectra taken at low temperature.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00723-008-0120-x", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1102112", 
        "issn": [
          "0937-9347", 
          "1613-7507"
        ], 
        "name": "Applied Magnetic Resonance", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3-4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "34"
      }
    ], 
    "keywords": [
      "dynamic nuclear polarization", 
      "nuclear magnetic resonance signals", 
      "NMR spectra", 
      "low temperatures", 
      "functional groups", 
      "hot solvent", 
      "small molecules", 
      "longitudinal relaxation time T1", 
      "methyl group", 
      "resonance signals", 
      "relaxation time T1", 
      "DNP experiments", 
      "good contact", 
      "magnetic resonance signal", 
      "glassy state", 
      "nuclear polarization", 
      "enormous polarization", 
      "molecules", 
      "time T1", 
      "order of tens", 
      "solvent", 
      "such enhancement", 
      "potent method", 
      "dissolution", 
      "temperature", 
      "polarizability", 
      "polarization", 
      "spectra", 
      "enhancement", 
      "optimal enhancement", 
      "NMR magnet", 
      "substances", 
      "key factor", 
      "samples", 
      "range", 
      "tens", 
      "order", 
      "magnets", 
      "group", 
      "contact", 
      "method", 
      "state", 
      "interesting role", 
      "sensitivity", 
      "recent implementation", 
      "experiments", 
      "T1", 
      "signals", 
      "thousands", 
      "role", 
      "factors", 
      "implementation", 
      "determinants", 
      "determinants of polarizability", 
      "long longitudinal relaxation times T1", 
      "Ex Situ DNP Experiments", 
      "Situ DNP Experiments"
    ], 
    "name": "Determinants for Optimal Enhancement in Ex Situ DNP Experiments", 
    "pagination": "483-494", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1019249575"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00723-008-0120-x"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00723-008-0120-x", 
      "https://app.dimensions.ai/details/publication/pub.1019249575"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_457.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00723-008-0120-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00723-008-0120-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00723-008-0120-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00723-008-0120-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00723-008-0120-x'


 

This table displays all metadata directly associated to this object as RDF triples.

136 TRIPLES      21 PREDICATES      83 URIs      75 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00723-008-0120-x schema:about anzsrc-for:03
2 anzsrc-for:0304
3 schema:author N46e913e126c44b6eb86074e233e1427a
4 schema:datePublished 2008-08
5 schema:datePublishedReg 2008-08-01
6 schema:description Abstract.Dynamic nuclear polarization (DNP) is a potent method to enhance the sensitivity of nuclear magnetic resonance (NMR) signals. In a recent implementation of DNP, samples are polarized at low temperature in a glassy state followed by dissolution with hot solvent and transfer to an NMR magnet (J.H. Ardenkjaer-Larsen, B. Fridlund, A. Gram, G. Hansson, L. Hansson, M.H. Lerche, R. Servin, M. Thaning, K. Golman: Proc. Natl. Acad. Sci. USA 100, 10158, 2003). Although enormous polarizations in the order of tens of thousands were reported, such enhancements were only obtained for very few molecules. Here we have polarized a range of small molecules in order to identify determinants of polarizability. The key factors include functional groups which allow for a good contact to the radical and substances with long longitudinal relaxation times T1. We also observe that methyl groups play a particularly interesting role in 13C-DNP-NMR spectra taken at low temperature.
7 schema:genre article
8 schema:inLanguage en
9 schema:isAccessibleForFree false
10 schema:isPartOf N3bac13228ef04850956278b70222dd6e
11 Nb36912f1b055462b9eb1a10aee278193
12 sg:journal.1102112
13 schema:keywords DNP experiments
14 Ex Situ DNP Experiments
15 NMR magnet
16 NMR spectra
17 Situ DNP Experiments
18 T1
19 contact
20 determinants
21 determinants of polarizability
22 dissolution
23 dynamic nuclear polarization
24 enhancement
25 enormous polarization
26 experiments
27 factors
28 functional groups
29 glassy state
30 good contact
31 group
32 hot solvent
33 implementation
34 interesting role
35 key factor
36 long longitudinal relaxation times T1
37 longitudinal relaxation time T1
38 low temperatures
39 magnetic resonance signal
40 magnets
41 method
42 methyl group
43 molecules
44 nuclear magnetic resonance signals
45 nuclear polarization
46 optimal enhancement
47 order
48 order of tens
49 polarizability
50 polarization
51 potent method
52 range
53 recent implementation
54 relaxation time T1
55 resonance signals
56 role
57 samples
58 sensitivity
59 signals
60 small molecules
61 solvent
62 spectra
63 state
64 substances
65 such enhancement
66 temperature
67 tens
68 thousands
69 time T1
70 schema:name Determinants for Optimal Enhancement in Ex Situ DNP Experiments
71 schema:pagination 483-494
72 schema:productId N2f721e3a1f9a4af0a21e5fd9220f096e
73 N49bd658870f5472287e3946122fd25ab
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019249575
75 https://doi.org/10.1007/s00723-008-0120-x
76 schema:sdDatePublished 2021-12-01T19:19
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher N7cc4551f14434addb2e10ef5d9eb1609
79 schema:url https://doi.org/10.1007/s00723-008-0120-x
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N2f721e3a1f9a4af0a21e5fd9220f096e schema:name dimensions_id
84 schema:value pub.1019249575
85 rdf:type schema:PropertyValue
86 N3bac13228ef04850956278b70222dd6e schema:volumeNumber 34
87 rdf:type schema:PublicationVolume
88 N46e913e126c44b6eb86074e233e1427a rdf:first sg:person.011577166122.92
89 rdf:rest N8c5bd5a3d4334561aae7800508473e53
90 N49bd658870f5472287e3946122fd25ab schema:name doi
91 schema:value 10.1007/s00723-008-0120-x
92 rdf:type schema:PropertyValue
93 N5bba08fa51474a289ccab42e025151a3 rdf:first sg:person.01112544071.19
94 rdf:rest N65b5470dd44e458c8b89ce17f899ba21
95 N65b5470dd44e458c8b89ce17f899ba21 rdf:first sg:person.0733543446.54
96 rdf:rest rdf:nil
97 N7cc4551f14434addb2e10ef5d9eb1609 schema:name Springer Nature - SN SciGraph project
98 rdf:type schema:Organization
99 N8c5bd5a3d4334561aae7800508473e53 rdf:first sg:person.0652127343.27
100 rdf:rest N5bba08fa51474a289ccab42e025151a3
101 Nb36912f1b055462b9eb1a10aee278193 schema:issueNumber 3-4
102 rdf:type schema:PublicationIssue
103 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
104 schema:name Chemical Sciences
105 rdf:type schema:DefinedTerm
106 anzsrc-for:0304 schema:inDefinedTermSet anzsrc-for:
107 schema:name Medicinal and Biomolecular Chemistry
108 rdf:type schema:DefinedTerm
109 sg:journal.1102112 schema:issn 0937-9347
110 1613-7507
111 schema:name Applied Magnetic Resonance
112 schema:publisher Springer Nature
113 rdf:type schema:Periodical
114 sg:person.01112544071.19 schema:affiliation grid-institutes:grid.6572.6
115 schema:familyName Ludwig
116 schema:givenName C.
117 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112544071.19
118 rdf:type schema:Person
119 sg:person.011577166122.92 schema:affiliation grid-institutes:grid.6572.6
120 schema:familyName Emwas
121 schema:givenName A.-H.
122 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011577166122.92
123 rdf:type schema:Person
124 sg:person.0652127343.27 schema:affiliation grid-institutes:grid.6572.6
125 schema:familyName Saunders
126 schema:givenName M.
127 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652127343.27
128 rdf:type schema:Person
129 sg:person.0733543446.54 schema:affiliation grid-institutes:grid.6572.6
130 schema:familyName Günther
131 schema:givenName U. L.
132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733543446.54
133 rdf:type schema:Person
134 grid-institutes:grid.6572.6 schema:alternateName Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, UK
135 schema:name Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, UK
136 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...