Stress responsiveness of vindoline accumulation in Catharanthus roseus leaves is mediated through co-expression of allene oxide cyclase with pathway genes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-08-30

AUTHORS

Maneesha Mall, Karuna Shanker, Abdul Samad, Alok Kalra, Velusamy Sundaresan, Ashutosh K. Shukla

ABSTRACT

Vindoline is an important alkaloid produced in Catharanthus roseus leaves. It is the more important monomer of the scarce and costly anticancer bisindole alkaloids, vincristine, and vinblastine, as unlike catharanthine (the other monomer), its biosynthesis is restricted to the leaves. Here, biotic (bacterial endophyte, phytoplasma, virus) and abiotic (temperature, salinity, SA, MeJa) factors were studied for their effect on vindoline accumulation in C. roseus. Variations in vindoline pathway-related gene expression were reflected in changes in vindoline content. Since allene oxide cyclase (CrAOC) is involved in jasmonate biosynthesis and MeJa modulates many vindoline pathway genes, the correlation between CrAOC expression and vindoline content was studied. It was taken up for full-length cloning, tissue-specific expression profiling, in silico analyses, and upstream genomic region analysis for cis-regulatory elements. Co-expression analysis of CrAOC with vindoline metabolism-related genes under the influence of aforementioned abiotic/biotic factors indicated its stronger direct correlation with the tabersonine-to-vindoline genes (t16h, omt, t3o, t3r, nmt, d4h, dat) as compared to the pre-tabersonine genes (tdc, str, sgd). Its expression was inversely related to that of downstream-acting peroxidase (prx) (except under temperature stress). Direct/positive relationship of CrAOC expression with vindoline content established it as a key gene modulating vindoline accumulation in C. roseus. More... »

PAGES

755-773

References to SciGraph publications

  • 2007-12. Alkaloid variations in Catharanthus roseus seedlings treated by different temperatures in short term and long term in JOURNAL OF FORESTRY RESEARCH
  • 2012-08-07. CrMPK3, a mitogen activated protein kinase from Catharanthus roseusand its possible role in stress induced biosynthesis of monoterpenoid indole alkaloids in BMC PLANT BIOLOGY
  • 2010-12-28. Molecular identification of a phytoplasma associated with Ajwain (Trachyspermum ammi) in India in EUROPEAN JOURNAL OF PLANT PATHOLOGY
  • 2010-03-09. Influence of cellular differentiation and elicitation on intermediate and late steps of terpenoid indole alkaloid biosynthesis in Catharanthus roseus in PROTOPLASMA
  • 2020-09-04. The expression of Terpenoid Indole Alkaloid (TIAs) pathway genes in Catharanthus roseus in response to salicylic acid treatment in MOLECULAR BIOLOGY REPORTS
  • 2007-07-07. Downregulation of terpenoid indole alkaloid biosynthetic pathway by low temperature and cloning of a AP2 type C-repeat binding factor (CBF) from Catharanthus roseus (L). G. Don in PLANT CELL REPORTS
  • 2014-03-23. Correspondence between flowers and leaves in terpenoid indole alkaloid metabolism of the phytoplasma-infected Catharanthus roseus plants in PROTOPLASMA
  • 2003-04. Jasmonate biosynthesis and the allene oxide cyclase family of Arabidopsis thaliana in PLANT MOLECULAR BIOLOGY
  • 2012-06-09. New evidences about strictosidine synthase (Str) regulation by salinity, cold stress and nitric oxide in Catharanthus roseus in JOURNAL OF PLANT BIOCHEMISTRY AND BIOTECHNOLOGY
  • 2008. Natural infection of periwinkle ( Catharanthus roseus ) with Cucumber mosaic virus , subgroup IB in AUSTRALASIAN PLANT DISEASE NOTES
  • 2012-08-29. Overexpression of allene oxide cyclase promoted tanshinone/phenolic acid production in Salvia miltiorrhiza in PLANT CELL REPORTS
  • 2016-05-25. Fungal endophytes of Catharanthus roseus enhance vindoline content by modulating structural and regulatory genes related to terpenoid indole alkaloid biosynthesis in SCIENTIFIC REPORTS
  • 2010-10-27. Salicylic acid mitigates salinity stress by improving antioxidant defence system and enhances vincristine and vinblastine alkaloids production in periwinkle [Catharanthus roseus (L.) G. Don] in ACTA PHYSIOLOGIAE PLANTARUM
  • 2004-09. Growth, metabolic profiling and enzymes activities of Catharanthus roseus seedlings treated with plant growth regulators in PLANT GROWTH REGULATION
  • 2014-06-20. Analyses of Catharanthus roseus and Arabidopsis thaliana WRKY transcription factors reveal involvement in jasmonate signaling in BMC GENOMICS
  • 2009-02-12. Promotion of nicotine biosynthesis in transgenic tobacco by overexpressing allene oxide cyclase from Hyoscyamus niger in PLANTA
  • 2011-04-06. Sequence and expression divergence of the AOC gene family in soybean: insights into functional diversity for stress responses in BIOTECHNOLOGY LETTERS
  • 2009-12-25. Effect of plant growth regulators on the biosynthesis of vinblastine, vindoline and catharanthine in Catharanthus roseus in PLANT GROWTH REGULATION
  • 2007-03-10. Catharanthus terpenoid indole alkaloids: biosynthesis and regulation in PHYTOCHEMISTRY REVIEWS
  • 2010-03-30. Methyl jasmonic acid induced expression pattern of terpenoid indole alkaloid pathway genes in Catharanthus roseus seedlings in PLANT GROWTH REGULATION
  • 2010-01-14. Molecular cloning and characterization of a jasmonate biosynthetic pathway gene for allene oxide cyclase from Jatropha curcas in ACTA PHYSIOLOGIAE PLANTARUM
  • 2008-10-11. Allene Oxide Cyclase from Camptotheca acuminata Improves Tolerance Against Low Temperature and Salt Stress in Tobacco and Bacteria in MOLECULAR BIOTECHNOLOGY
  • 1999-03. Rapid Isolation of DNA from Dry and Fresh Samples of Plants Producing Large Amounts of Secondary Metabolites and Essential Oils in PLANT MOLECULAR BIOLOGY REPORTER
  • 2016-01-21. Endophytes of opium poppy differentially modulate host plant productivity and genes for the biosynthetic pathway of benzylisoquinoline alkaloids in PLANTA
  • 2004-03-04. Catharanthus roseus L. plants and explants infected with phytoplasmas: alkaloid production and structural observations in PROTOPLASMA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00709-021-01701-6

    DOI

    http://dx.doi.org/10.1007/s00709-021-01701-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1140743776

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34459997


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Alkaloids", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Catharanthus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Plant", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intramolecular Oxidoreductases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Plant Leaves", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vinblastine", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "CSIR-Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, 226015, Lucknow, UP, India", 
              "id": "http://www.grid.ac/institutes/grid.417631.6", 
              "name": [
                "CSIR-Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, 226015, Lucknow, UP, India"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mall", 
            "givenName": "Maneesha", 
            "id": "sg:person.01131501072.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131501072.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CSIR-Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, 226015, Lucknow, UP, India", 
              "id": "http://www.grid.ac/institutes/grid.417631.6", 
              "name": [
                "CSIR-Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, 226015, Lucknow, UP, India"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shanker", 
            "givenName": "Karuna", 
            "id": "sg:person.0650767015.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650767015.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CSIR-Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, 226015, Lucknow, UP, India", 
              "id": "http://www.grid.ac/institutes/grid.417631.6", 
              "name": [
                "CSIR-Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, 226015, Lucknow, UP, India"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Samad", 
            "givenName": "Abdul", 
            "id": "sg:person.01323030363.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323030363.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CSIR-Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, 226015, Lucknow, UP, India", 
              "id": "http://www.grid.ac/institutes/grid.417631.6", 
              "name": [
                "CSIR-Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, 226015, Lucknow, UP, India"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kalra", 
            "givenName": "Alok", 
            "id": "sg:person.01157615463.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157615463.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CSIR-Central Institute of Medicinal and Aromatic Plants, Research Centre, Allalasandra, GKVK Post, 560065, Bengaluru, Karnataka, India", 
              "id": "http://www.grid.ac/institutes/grid.417631.6", 
              "name": [
                "CSIR-Central Institute of Medicinal and Aromatic Plants, Research Centre, Allalasandra, GKVK Post, 560065, Bengaluru, Karnataka, India"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sundaresan", 
            "givenName": "Velusamy", 
            "id": "sg:person.01036114351.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036114351.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CSIR-Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, 226015, Lucknow, UP, India", 
              "id": "http://www.grid.ac/institutes/grid.417631.6", 
              "name": [
                "CSIR-Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, 226015, Lucknow, UP, India"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shukla", 
            "givenName": "Ashutosh K.", 
            "id": "sg:person.0746716663.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746716663.99"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s10658-010-9736-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025216650", 
              "https://doi.org/10.1007/s10658-010-9736-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-15-502", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001022692", 
              "https://doi.org/10.1186/1471-2164-15-502"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00299-007-0383-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032120499", 
              "https://doi.org/10.1007/s00299-007-0383-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11033-020-05759-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1130576349", 
              "https://doi.org/10.1007/s11033-020-05759-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00709-003-0024-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027494485", 
              "https://doi.org/10.1007/s00709-003-0024-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10725-009-9429-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052993951", 
              "https://doi.org/10.1007/s10725-009-9429-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep26583", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045979555", 
              "https://doi.org/10.1038/srep26583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11676-007-0063-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003483500", 
              "https://doi.org/10.1007/s11676-007-0063-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1023049319723", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022503059", 
              "https://doi.org/10.1023/a:1023049319723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11101-006-9047-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018887430", 
              "https://doi.org/10.1007/s11101-006-9047-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11738-010-0631-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032228761", 
              "https://doi.org/10.1007/s11738-010-0631-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00425-016-2467-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020714787", 
              "https://doi.org/10.1007/s00425-016-2467-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2229-12-134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009173528", 
              "https://doi.org/10.1186/1471-2229-12-134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12033-008-9106-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051747994", 
              "https://doi.org/10.1007/s12033-008-9106-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10529-011-0585-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030912714", 
              "https://doi.org/10.1007/s10529-011-0585-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10725-010-9468-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012285422", 
              "https://doi.org/10.1007/s10725-010-9468-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13562-012-0118-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001793949", 
              "https://doi.org/10.1007/s13562-012-0118-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00299-012-1334-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023658337", 
              "https://doi.org/10.1007/s00299-012-1334-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10725-004-2604-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007971248", 
              "https://doi.org/10.1007/s10725-004-2604-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00709-010-0120-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010206130", 
              "https://doi.org/10.1007/s00709-010-0120-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00709-014-0621-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031405902", 
              "https://doi.org/10.1007/s00709-014-0621-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00425-009-0896-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006864442", 
              "https://doi.org/10.1007/s00425-009-0896-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1007528101452", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020688090", 
              "https://doi.org/10.1023/a:1007528101452"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1071/dn08013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058203888", 
              "https://doi.org/10.1071/dn08013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11738-009-0430-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051892804", 
              "https://doi.org/10.1007/s11738-009-0430-0"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2021-08-30", 
        "datePublishedReg": "2021-08-30", 
        "description": "Abstract\nVindoline is an important alkaloid produced in Catharanthus roseus leaves. It is the more important monomer of the scarce and costly anticancer bisindole alkaloids, vincristine, and vinblastine, as unlike catharanthine (the other monomer), its biosynthesis is restricted to the leaves. Here, biotic (bacterial endophyte, phytoplasma, virus) and abiotic (temperature, salinity, SA, MeJa) factors were studied for their effect on vindoline accumulation in C. roseus. Variations in vindoline pathway-related gene expression were reflected in changes in vindoline content. Since allene oxide cyclase (CrAOC) is involved in jasmonate biosynthesis and MeJa modulates many vindoline pathway genes, the correlation between CrAOC expression and vindoline content was studied. It was taken up for full-length cloning, tissue-specific expression profiling, in silico analyses, and upstream genomic region analysis for cis-regulatory elements. Co-expression analysis of CrAOC with vindoline metabolism-related genes under the influence of aforementioned abiotic/biotic factors indicated its stronger direct correlation with the tabersonine-to-vindoline genes (t16h, omt, t3o, t3r, nmt, d4h, dat) as compared to the pre-tabersonine genes (tdc, str, sgd). Its expression was inversely related to that of downstream-acting peroxidase (prx) (except under temperature stress). Direct/positive relationship of CrAOC expression with vindoline content established it as a key gene modulating vindoline accumulation in C. roseus.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00709-021-01701-6", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1118135", 
            "issn": [
              "0033-183X", 
              "1615-6102"
            ], 
            "name": "Protoplasma", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "259"
          }
        ], 
        "keywords": [
          "allene oxide cyclase", 
          "oxide cyclase", 
          "vindoline accumulation", 
          "pathway genes", 
          "vindoline content", 
          "tissue-specific expression profiling", 
          "C. roseus", 
          "pathway-related gene expression", 
          "cis-regulatory elements", 
          "co-expression analysis", 
          "Catharanthus roseus leaves", 
          "full-length cloning", 
          "jasmonate biosynthesis", 
          "metabolism-related genes", 
          "key genes", 
          "biotic factors", 
          "abiotic factors", 
          "expression profiling", 
          "gene expression", 
          "silico analysis", 
          "genes", 
          "leaves", 
          "biosynthesis", 
          "stress responsiveness", 
          "important alkaloids", 
          "roseus", 
          "expression", 
          "accumulation", 
          "region analysis", 
          "cyclase", 
          "MeJA", 
          "cloning", 
          "bisindole alkaloids", 
          "profiling", 
          "tabersonine", 
          "vindoline", 
          "catharanthine", 
          "alkaloids", 
          "peroxidase", 
          "positive relationship", 
          "direct correlation", 
          "important monomers", 
          "content", 
          "analysis", 
          "factors", 
          "variation", 
          "vinblastine", 
          "monomers", 
          "changes", 
          "responsiveness", 
          "elements", 
          "correlation", 
          "relationship", 
          "effect", 
          "strong direct correlation", 
          "influence", 
          "vincristine"
        ], 
        "name": "Stress responsiveness of vindoline accumulation in Catharanthus roseus leaves is mediated through co-expression of allene oxide cyclase with pathway genes", 
        "pagination": "755-773", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1140743776"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00709-021-01701-6"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "34459997"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00709-021-01701-6", 
          "https://app.dimensions.ai/details/publication/pub.1140743776"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-05-20T07:37", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_889.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00709-021-01701-6"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00709-021-01701-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00709-021-01701-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00709-021-01701-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00709-021-01701-6'


     

    This table displays all metadata directly associated to this object as RDF triples.

    280 TRIPLES      22 PREDICATES      114 URIs      81 LITERALS      13 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00709-021-01701-6 schema:about N208deec7550a43bb8c86546840d5a250
    2 N4b25f9fc91314121af69d28567c8f303
    3 Nadfc065993d34fe39f43949bf89141c1
    4 Nb17d9c9b39bc42d092ba5f2e1389d304
    5 Nbc8deb6a588b44e8a0df3060e77f6b17
    6 Nc6d3c6ee75ca4440934b1415c8651081
    7 anzsrc-for:06
    8 anzsrc-for:0604
    9 schema:author N6ae94e0ba43145f08ddef1f9877db181
    10 schema:citation sg:pub.10.1007/s00299-007-0383-y
    11 sg:pub.10.1007/s00299-012-1334-9
    12 sg:pub.10.1007/s00425-009-0896-4
    13 sg:pub.10.1007/s00425-016-2467-9
    14 sg:pub.10.1007/s00709-003-0024-4
    15 sg:pub.10.1007/s00709-010-0120-1
    16 sg:pub.10.1007/s00709-014-0621-4
    17 sg:pub.10.1007/s10529-011-0585-9
    18 sg:pub.10.1007/s10658-010-9736-4
    19 sg:pub.10.1007/s10725-004-2604-5
    20 sg:pub.10.1007/s10725-009-9429-1
    21 sg:pub.10.1007/s10725-010-9468-7
    22 sg:pub.10.1007/s11033-020-05759-y
    23 sg:pub.10.1007/s11101-006-9047-8
    24 sg:pub.10.1007/s11676-007-0063-3
    25 sg:pub.10.1007/s11738-009-0430-0
    26 sg:pub.10.1007/s11738-010-0631-6
    27 sg:pub.10.1007/s12033-008-9106-z
    28 sg:pub.10.1007/s13562-012-0118-1
    29 sg:pub.10.1023/a:1007528101452
    30 sg:pub.10.1023/a:1023049319723
    31 sg:pub.10.1038/srep26583
    32 sg:pub.10.1071/dn08013
    33 sg:pub.10.1186/1471-2164-15-502
    34 sg:pub.10.1186/1471-2229-12-134
    35 schema:datePublished 2021-08-30
    36 schema:datePublishedReg 2021-08-30
    37 schema:description Abstract Vindoline is an important alkaloid produced in Catharanthus roseus leaves. It is the more important monomer of the scarce and costly anticancer bisindole alkaloids, vincristine, and vinblastine, as unlike catharanthine (the other monomer), its biosynthesis is restricted to the leaves. Here, biotic (bacterial endophyte, phytoplasma, virus) and abiotic (temperature, salinity, SA, MeJa) factors were studied for their effect on vindoline accumulation in C. roseus. Variations in vindoline pathway-related gene expression were reflected in changes in vindoline content. Since allene oxide cyclase (CrAOC) is involved in jasmonate biosynthesis and MeJa modulates many vindoline pathway genes, the correlation between CrAOC expression and vindoline content was studied. It was taken up for full-length cloning, tissue-specific expression profiling, in silico analyses, and upstream genomic region analysis for cis-regulatory elements. Co-expression analysis of CrAOC with vindoline metabolism-related genes under the influence of aforementioned abiotic/biotic factors indicated its stronger direct correlation with the tabersonine-to-vindoline genes (t16h, omt, t3o, t3r, nmt, d4h, dat) as compared to the pre-tabersonine genes (tdc, str, sgd). Its expression was inversely related to that of downstream-acting peroxidase (prx) (except under temperature stress). Direct/positive relationship of CrAOC expression with vindoline content established it as a key gene modulating vindoline accumulation in C. roseus.
    38 schema:genre article
    39 schema:inLanguage en
    40 schema:isAccessibleForFree false
    41 schema:isPartOf N43728a33c51647a6b3ff0ebb81c453a2
    42 N581f7e5128e140e098a77e00365afb18
    43 sg:journal.1118135
    44 schema:keywords C. roseus
    45 Catharanthus roseus leaves
    46 MeJA
    47 abiotic factors
    48 accumulation
    49 alkaloids
    50 allene oxide cyclase
    51 analysis
    52 biosynthesis
    53 biotic factors
    54 bisindole alkaloids
    55 catharanthine
    56 changes
    57 cis-regulatory elements
    58 cloning
    59 co-expression analysis
    60 content
    61 correlation
    62 cyclase
    63 direct correlation
    64 effect
    65 elements
    66 expression
    67 expression profiling
    68 factors
    69 full-length cloning
    70 gene expression
    71 genes
    72 important alkaloids
    73 important monomers
    74 influence
    75 jasmonate biosynthesis
    76 key genes
    77 leaves
    78 metabolism-related genes
    79 monomers
    80 oxide cyclase
    81 pathway genes
    82 pathway-related gene expression
    83 peroxidase
    84 positive relationship
    85 profiling
    86 region analysis
    87 relationship
    88 responsiveness
    89 roseus
    90 silico analysis
    91 stress responsiveness
    92 strong direct correlation
    93 tabersonine
    94 tissue-specific expression profiling
    95 variation
    96 vinblastine
    97 vincristine
    98 vindoline
    99 vindoline accumulation
    100 vindoline content
    101 schema:name Stress responsiveness of vindoline accumulation in Catharanthus roseus leaves is mediated through co-expression of allene oxide cyclase with pathway genes
    102 schema:pagination 755-773
    103 schema:productId N207fb7a82fdc419ebe0c51e61a189a5b
    104 N353f8b55fb144212a39938d7870376d0
    105 Nec961a8b391f4d0e835463d62cd51b8a
    106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1140743776
    107 https://doi.org/10.1007/s00709-021-01701-6
    108 schema:sdDatePublished 2022-05-20T07:37
    109 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    110 schema:sdPublisher N3be7d4e6384e488f8d03970fa52f0c03
    111 schema:url https://doi.org/10.1007/s00709-021-01701-6
    112 sgo:license sg:explorer/license/
    113 sgo:sdDataset articles
    114 rdf:type schema:ScholarlyArticle
    115 N207fb7a82fdc419ebe0c51e61a189a5b schema:name pubmed_id
    116 schema:value 34459997
    117 rdf:type schema:PropertyValue
    118 N208deec7550a43bb8c86546840d5a250 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Catharanthus
    120 rdf:type schema:DefinedTerm
    121 N353f8b55fb144212a39938d7870376d0 schema:name doi
    122 schema:value 10.1007/s00709-021-01701-6
    123 rdf:type schema:PropertyValue
    124 N3be7d4e6384e488f8d03970fa52f0c03 schema:name Springer Nature - SN SciGraph project
    125 rdf:type schema:Organization
    126 N43728a33c51647a6b3ff0ebb81c453a2 schema:issueNumber 3
    127 rdf:type schema:PublicationIssue
    128 N47fc8c979d154b579ff077f3d4736dfa rdf:first sg:person.0746716663.99
    129 rdf:rest rdf:nil
    130 N4b25f9fc91314121af69d28567c8f303 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Vinblastine
    132 rdf:type schema:DefinedTerm
    133 N581f7e5128e140e098a77e00365afb18 schema:volumeNumber 259
    134 rdf:type schema:PublicationVolume
    135 N676ff9019a134b59b1b94fb6ec5f80d7 rdf:first sg:person.01323030363.45
    136 rdf:rest Nb5864f7ac5a945fa8be1725f48938619
    137 N6ae94e0ba43145f08ddef1f9877db181 rdf:first sg:person.01131501072.21
    138 rdf:rest Neac93cfb2f654315b7cdae009e528afb
    139 Nadfc065993d34fe39f43949bf89141c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Plant Leaves
    141 rdf:type schema:DefinedTerm
    142 Nb17d9c9b39bc42d092ba5f2e1389d304 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Gene Expression Regulation, Plant
    144 rdf:type schema:DefinedTerm
    145 Nb5864f7ac5a945fa8be1725f48938619 rdf:first sg:person.01157615463.85
    146 rdf:rest Ncc36aeff53e74517b937bef2b7d19082
    147 Nbc8deb6a588b44e8a0df3060e77f6b17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Alkaloids
    149 rdf:type schema:DefinedTerm
    150 Nc6d3c6ee75ca4440934b1415c8651081 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Intramolecular Oxidoreductases
    152 rdf:type schema:DefinedTerm
    153 Ncc36aeff53e74517b937bef2b7d19082 rdf:first sg:person.01036114351.22
    154 rdf:rest N47fc8c979d154b579ff077f3d4736dfa
    155 Neac93cfb2f654315b7cdae009e528afb rdf:first sg:person.0650767015.23
    156 rdf:rest N676ff9019a134b59b1b94fb6ec5f80d7
    157 Nec961a8b391f4d0e835463d62cd51b8a schema:name dimensions_id
    158 schema:value pub.1140743776
    159 rdf:type schema:PropertyValue
    160 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    161 schema:name Biological Sciences
    162 rdf:type schema:DefinedTerm
    163 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    164 schema:name Genetics
    165 rdf:type schema:DefinedTerm
    166 sg:journal.1118135 schema:issn 0033-183X
    167 1615-6102
    168 schema:name Protoplasma
    169 schema:publisher Springer Nature
    170 rdf:type schema:Periodical
    171 sg:person.01036114351.22 schema:affiliation grid-institutes:grid.417631.6
    172 schema:familyName Sundaresan
    173 schema:givenName Velusamy
    174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036114351.22
    175 rdf:type schema:Person
    176 sg:person.01131501072.21 schema:affiliation grid-institutes:grid.417631.6
    177 schema:familyName Mall
    178 schema:givenName Maneesha
    179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131501072.21
    180 rdf:type schema:Person
    181 sg:person.01157615463.85 schema:affiliation grid-institutes:grid.417631.6
    182 schema:familyName Kalra
    183 schema:givenName Alok
    184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157615463.85
    185 rdf:type schema:Person
    186 sg:person.01323030363.45 schema:affiliation grid-institutes:grid.417631.6
    187 schema:familyName Samad
    188 schema:givenName Abdul
    189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323030363.45
    190 rdf:type schema:Person
    191 sg:person.0650767015.23 schema:affiliation grid-institutes:grid.417631.6
    192 schema:familyName Shanker
    193 schema:givenName Karuna
    194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650767015.23
    195 rdf:type schema:Person
    196 sg:person.0746716663.99 schema:affiliation grid-institutes:grid.417631.6
    197 schema:familyName Shukla
    198 schema:givenName Ashutosh K.
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746716663.99
    200 rdf:type schema:Person
    201 sg:pub.10.1007/s00299-007-0383-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1032120499
    202 https://doi.org/10.1007/s00299-007-0383-y
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1007/s00299-012-1334-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023658337
    205 https://doi.org/10.1007/s00299-012-1334-9
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1007/s00425-009-0896-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006864442
    208 https://doi.org/10.1007/s00425-009-0896-4
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1007/s00425-016-2467-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020714787
    211 https://doi.org/10.1007/s00425-016-2467-9
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1007/s00709-003-0024-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027494485
    214 https://doi.org/10.1007/s00709-003-0024-4
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1007/s00709-010-0120-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010206130
    217 https://doi.org/10.1007/s00709-010-0120-1
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1007/s00709-014-0621-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031405902
    220 https://doi.org/10.1007/s00709-014-0621-4
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1007/s10529-011-0585-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030912714
    223 https://doi.org/10.1007/s10529-011-0585-9
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1007/s10658-010-9736-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025216650
    226 https://doi.org/10.1007/s10658-010-9736-4
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1007/s10725-004-2604-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007971248
    229 https://doi.org/10.1007/s10725-004-2604-5
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1007/s10725-009-9429-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052993951
    232 https://doi.org/10.1007/s10725-009-9429-1
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1007/s10725-010-9468-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012285422
    235 https://doi.org/10.1007/s10725-010-9468-7
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1007/s11033-020-05759-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1130576349
    238 https://doi.org/10.1007/s11033-020-05759-y
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1007/s11101-006-9047-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018887430
    241 https://doi.org/10.1007/s11101-006-9047-8
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1007/s11676-007-0063-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003483500
    244 https://doi.org/10.1007/s11676-007-0063-3
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1007/s11738-009-0430-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051892804
    247 https://doi.org/10.1007/s11738-009-0430-0
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1007/s11738-010-0631-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032228761
    250 https://doi.org/10.1007/s11738-010-0631-6
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1007/s12033-008-9106-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1051747994
    253 https://doi.org/10.1007/s12033-008-9106-z
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1007/s13562-012-0118-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001793949
    256 https://doi.org/10.1007/s13562-012-0118-1
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1023/a:1007528101452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020688090
    259 https://doi.org/10.1023/a:1007528101452
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1023/a:1023049319723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022503059
    262 https://doi.org/10.1023/a:1023049319723
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/srep26583 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045979555
    265 https://doi.org/10.1038/srep26583
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1071/dn08013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058203888
    268 https://doi.org/10.1071/dn08013
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1186/1471-2164-15-502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001022692
    271 https://doi.org/10.1186/1471-2164-15-502
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1186/1471-2229-12-134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009173528
    274 https://doi.org/10.1186/1471-2229-12-134
    275 rdf:type schema:CreativeWork
    276 grid-institutes:grid.417631.6 schema:alternateName CSIR-Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, 226015, Lucknow, UP, India
    277 CSIR-Central Institute of Medicinal and Aromatic Plants, Research Centre, Allalasandra, GKVK Post, 560065, Bengaluru, Karnataka, India
    278 schema:name CSIR-Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, 226015, Lucknow, UP, India
    279 CSIR-Central Institute of Medicinal and Aromatic Plants, Research Centre, Allalasandra, GKVK Post, 560065, Bengaluru, Karnataka, India
    280 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...