Synthesis and Biological Activity of a Series of Methylene-Expanded Oxetanocin Nucleoside Analogues View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-04

AUTHORS

Michael E. Jung, Akemi Toyota, Erik de Clercq, Jan Balzarini

ABSTRACT

A series of methylene-expanded oxetanocin nucleoside analogues, e.g. analogues of 2 and the known antiviral nucleosides AZT, FLT, and ddC (3) were prepared by a very direct route beginning with the readily available (S )-glycidol 4 and proceeding via the dihydrofuran-3-methanols 9a,b. Biological testing of these modified nucleosides indicates that they are non-cytotoxic compounds with generally weak antiviral activity. However, the guanosine analogue 2G showed pronounced activity vs. herpes simplex virus type 1 (HSV-1) in cell culture and was HSV-1-encoded thymidine kinase dependent. This compound is therefore an interesting new lead structure for the development of new anti-HSV agents. More... »

PAGES

499-520

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s007060200024

DOI

http://dx.doi.org/10.1007/s007060200024

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034430057


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