Synthesis and Biological Activity of Oxidation Products of the Antiprogestine Mifepristone View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-03

AUTHORS

Rainer Strommer, Wolfgang Strauss, Helmut Emmert, Reinhard Sailer, Rudolf Steiner, Eva Reisinger, Ernst Haslinger, Hans W. Schramm

ABSTRACT

Selenium dioxide oxidation allows the selective introduction of a hydroxyl group at position 6 of the steroid skeleton of the antihormone (11β, 17β)-11-(4-dimethylamino-phenyl)-17-hydroxyl-17-(1-propynyl)-estra-4,9-dien-3-one (mifepristone, RU 486) and leads in a one-step procedure to two diastereomeric oxidation products. Their structure (6α- and 6β-hydroxy-mifepristone) was determined by NMR spectroscopy. The antiprogestinic activity of the oxidation products is comparable to that of mifepristone. More... »

PAGES

387-392

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s007060170124

DOI

http://dx.doi.org/10.1007/s007060170124

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025858486


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