A Short and Efficient Synthesis of Novel N-(2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-2-carboxamides View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-06

AUTHORS

Ali Khalaj, Morteza Pirali, Hogatollah Matloubi, Reza Dowlatabadi

ABSTRACT

Several novel N-(2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-2-carboxamides were prepared by acyl coupling of 2-aminobenzophenones with α-(benzotriazol-1-yl)-N-acylglycines followed by displacement of the benzotriazole ring with ammonia and cyclization of the resulting monoacyl aminals. In addition to high yields and shorter reaction sequences due to avoiding deprotection and acylation of the protected 3-amino-1,4-benzodiazepin-2-one intermediates, the present approach did not involve the use of toxic and odoriferous materials as is the case with other methods. More... »

PAGES

747-752

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s007060170090

DOI

http://dx.doi.org/10.1007/s007060170090

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026528230


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