A Double Mannich-type Reaction in the 1,4,5,6-Tetrahydropyridine-2-thiolate Series: A Convenient Approach to Functionalized 3,7-Diazabicyclo[3.3.1]nonane Derivatives View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-05

AUTHORS

Victor V. Dotsenko, Sergey G. Krivokolysko, Victor P. Litvinov

ABSTRACT

The reaction of N-methylmorpholinium 5-alkoxy-carbonyl-4-aryl-3-cyano-2-oxo-1,4,5,6-tetrahydropyridine-2-thiolates with primary amines and formaldehyde under mild conditions afforded 7-substituted alkyl 9-aryl-5-cyano-2-oxo-4-thioxo-3,7-diazabicyclo[3.3.1]nonane-1-carboxylates in fair to good yields (52–74%).

PAGES

489-494

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00706-007-0620-7

DOI

http://dx.doi.org/10.1007/s00706-007-0620-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040414114


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