Synthesis of Pyrrolo[2,1-b]thiazol-3-one Derivatives View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-08-16

AUTHORS

Anton V. Tverdokhlebov, Alexander P. Andrushko, Andrey A. Tolmachev, Alexander N. Kostyuk, Alexander N. Chernega, Eduard B. Rusanov

ABSTRACT

Summary.Ethyl [4-oxo-3-(2-oxo-2-arylethyl)thiazolidin-2-ylidene]acetates and [4-oxo-3-(2-oxo-2-arylethyl)thiazolidin-2-ylidene]acetonitriles were shown to react with substituted benzaldehydes at the endocyclic methylene group leading to the corresponding 5-arylmethylidene derivatives. Their treatment with DMF · POCl3 complex yielded 3-oxo-5-aroyl-2-arylmethylidene-2,3-dihydropyrrolo[2,1-b]thiazole-7-carboxylic acids ethyl esters and -7-carbonitriles. The structures of the pyrrolothiazoles were confirmed by an X-ray crystallographic study, which indicated the (Z)-configuration at the arylmethylidene moiety. More... »

PAGES

1781-1790

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00706-005-0356-1

DOI

http://dx.doi.org/10.1007/s00706-005-0356-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042155693


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