Nucleotide sequence of the 5′-terminus of Newcastle disease virus and assembly of the complete genomic sequence: agreement with the “rule ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-10

AUTHORS

R. J. Phillips, A. C. R. Samson, P. T. Emmerson

ABSTRACT

We have determined the sequences of the 5' ends of three strains of Newcastle disease virus, permitting the assembly of the entire genomic sequence, which amounts to 15,186 nucleotides. This length is in agreement with the rule of six, which has been shown to determine replication efficiency in similar viruses. Comparison of the extreme 5' end of the trailer sequence with that of the 3'-terminal leader sequence of the virus reveals a high degree of complementarity. Variation between the 5'-terminal sequences of the different strains reveals the presence of alternative L gene polyadenylation signals, leading to correspondingly different trailer lengths. More... »

PAGES

1993-2002

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s007050050435

DOI

http://dx.doi.org/10.1007/s007050050435

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005047247

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9856086


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