Regulation of Hazara virus growth through apoptosis inhibition by viral nucleoprotein. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-04

AUTHORS

Yusuke Matsumoto, Takashi Nouchi, Keisuke Ohta, Machiko Nishio

ABSTRACT

Hazara virus (HAZV) is closely related to Crimean-Congo hemorrhagic fever virus (CCHFV), but differs in that it is non-pathogenic to humans. Since HAZV was isolated for the first time in 1954, the biological characteristics of this virus, particularly its behavior within culture cells, have not been well-studied, despite its importance as a surrogate model for CCHFV. Nucleoprotein (N) is the main component of viral nucleocapsid and is the most abundant virion protein, it is believed to play a pivotal role in the viral lifecycle. Generation of a series of anti-HAZV N monoclonal antibodies has enabled us to directly examine the involvement of this protein on viral growth. Observation of HAZV-infected cells revealed that this infection caused apoptosis, which was further characterized by DNA ladder and elevated caspase-3/7 activity. HAZV titers initially increased in cell culture, but after reaching the peak titer began to rapidly decline. HAZV particles were found to be very unstable in culture medium at 37 °C, and virus particles tend to lose infectivity at that point. HAZV N appears to inhibit apoptosis, thus can potentially support efficient viral propagation. More... »

References to SciGraph publications

Journal

TITLE

Archives of Virology

ISSUE

N/A

VOLUME

N/A

Author Affiliations

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  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/s00705-019-04236-7

    DOI

    http://dx.doi.org/10.1007/s00705-019-04236-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113185229

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30949813


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