Genomic and biological characterization of Newcastle disease viruses isolated from migratory mallards (Anas platyrhynchos) View Full Text


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Article Info

DATE

2018-04-30

AUTHORS

Momena Habib, Tahir Yaqub, Jawad Nazir, Wasim Shehzad, Aziz-ul-Rahman, Tayyebah Sohail, Nadia Mukhtar, Arsalan Mehboob, Muhammad Munir, Muhammad Zubair Shabbir

ABSTRACT

Given the global evolutionary dynamics of Newcastle disease viruses (NDVs), it is imperative to continue extensive surveillance, routine monitoring and characterization of isolates originating from natural reservoirs (waterfowls). In this report, we isolated and characterized two virulent NDV strains from clinically healthy mallard (Anas platyrhynchos). Both isolates had a genome of 15,192 nucleotides encoding six genes in an order of 3´-NP-P-M-F-HN-L-5´. The biological characteristics (mean death time: 49.5-50 hr, EID50108.5 ml−1) and presence of a typical cleavage site in the fusion (F) protein (112R-R-Q-K-R↓F117) confirmed the velogenic nature of these isolates. Phylogenetic analysis classified both isolates as members of genotype VII within class-II. Furthermore, based upon the hypervariable region of the F gene (375 nt), isolates showed clustering within sub-genotype VIIi. Similarity index and parallel comparison revealed a higher nucleotide divergence from commonly used vaccine strains; LaSota (21%) and Mukteswar (17%). A comparative residues analysis with representative strains of different genotypes, including vaccine strains, revealed a number of substitutions at important structural and functional domains within the F and hemagglutinin-neuraminidase (HN) proteins. Together, the results highlight consistent evolution among circulating NDVs supporting extensive surveillance of the virus in waterfowl to better elucidate epidemiology, evolutionary relationships and their impacts on commercial and backyard poultry. More... »

PAGES

2179-2188

References to SciGraph publications

  • 2016-08-08. Genetic characterization and phylogeny of pigeon paramyxovirus isolate (PPMV-1) from Pakistan in SPRINGERPLUS
  • 2013-11-09. Molecular epidemiology of Newcastle disease virus isolates from vaccinated commercial poultry farms in non-epidemic areas of Japan in VIROLOGY JOURNAL
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  • 2002-08. A summary of taxonomic changes recently approved by ICTV in ARCHIVES OF VIROLOGY
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  • 1993-09. Deduced amino acid sequences at the fusion protein cleavage site of Newcastle disease viruses showing variation in antigenicity and pathogenicity in ARCHIVES OF VIROLOGY
  • 2016-08-31. Repeated isolation of virulent Newcastle disease viruses of sub-genotype VIId from backyard chickens in Bulgaria and Ukraine between 2002 and 2013 in ARCHIVES OF VIROLOGY
  • 2013-07-11. Isolation and molecular characterization of Newcastle disease virus genotypes II and VIId in Egypt between 2011 and 2012 in VIRUS GENES
  • 2012-02-16. Genomic and biological characterization of a velogenic Newcastle disease virus isolated from a healthy backyard poultry flock in 2010 in VIROLOGY JOURNAL
  • 2000-11. Crystal structure of the multifunctional paramyxovirus hemagglutinin-neuraminidase in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 1996-02. Identification and grouping of Newcastle disease virus strains by restriction site analysis of a region from the F gene in ARCHIVES OF VIROLOGY
  • 2003-06. Pathotypical and genotypical characterization of strains of Newcastle disease virus isolated from outbreaks in chicken and goose flocks in some regions of China during 1985–2001 in ARCHIVES OF VIROLOGY
  • 2012-12-11. Genetic analysis of Newcastle disease virus from Punjab, Pakistan in VIRUS GENES
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    31 schema:description Given the global evolutionary dynamics of Newcastle disease viruses (NDVs), it is imperative to continue extensive surveillance, routine monitoring and characterization of isolates originating from natural reservoirs (waterfowls). In this report, we isolated and characterized two virulent NDV strains from clinically healthy mallard (Anas platyrhynchos). Both isolates had a genome of 15,192 nucleotides encoding six genes in an order of 3´-NP-P-M-F-HN-L-5´. The biological characteristics (mean death time: 49.5-50 hr, EID50108.5 ml−1) and presence of a typical cleavage site in the fusion (F) protein (112R-R-Q-K-R↓F117) confirmed the velogenic nature of these isolates. Phylogenetic analysis classified both isolates as members of genotype VII within class-II. Furthermore, based upon the hypervariable region of the F gene (375 nt), isolates showed clustering within sub-genotype VIIi. Similarity index and parallel comparison revealed a higher nucleotide divergence from commonly used vaccine strains; LaSota (21%) and Mukteswar (17%). A comparative residues analysis with representative strains of different genotypes, including vaccine strains, revealed a number of substitutions at important structural and functional domains within the F and hemagglutinin-neuraminidase (HN) proteins. Together, the results highlight consistent evolution among circulating NDVs supporting extensive surveillance of the virus in waterfowl to better elucidate epidemiology, evolutionary relationships and their impacts on commercial and backyard poultry.
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