Immunization with an HPV-16 L1-based chimeric virus-like particle containing HPV-16 E6 and E7 epitopes elicits long-lasting prophylactic and therapeutic efficacy ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-08-29

AUTHORS

Alberto Monroy-García, Miguel Angel Gómez-Lim, Benny Weiss-Steider, Jorge Hernández-Montes, Sara Huerta-Yepez, Jesús F. Rangel-Santiago, Edelmiro Santiago-Osorio, María de Lourdes Mora García

ABSTRACT

HPV L1-based virus-like particles vaccines (VLPs) efficiently induce temporary prophylactic activity through the induction of neutralizing antibodies; however, VLPs that can provide prophylactic as well as therapeutic properties for longer periods of time are needed. For this purpose, we generated a novel HPV 16 L1-based chimeric virus-like particle (cVLP) produced in plants that contains a string of T-cell epitopes from HPV 16 E6 and E7 fused to its C-terminus. In the present study, we analyzed the persistence of specific IgG antibodies with neutralizing activity induced by immunization with these cVLPs, as well as their therapeutic potential in a tumor model of C57BL/6 mice. We observed that these cVLPs induced persistent IgG antibodies for over 12 months, with reactivity and neutralizing activity for VLPs composed of only the HPV-16 L1 protein. Efficient protection for long periods of time and inhibition of tumor growth induced by TC-1 tumor cells expressing HPV-16 E6/E7 oncoproteins, as well as significant tumor reduction (57 %), were observed in mice immunized with these cVLPs. Finally, we discuss the possibility that chimeric particles of the type described in this work may be the basis for developing HPV prophylactic and therapeutic vaccines with high efficacy. More... »

PAGES

291-305

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00705-013-1819-z

DOI

http://dx.doi.org/10.1007/s00705-013-1819-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018708279

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23990055


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32 schema:description HPV L1-based virus-like particles vaccines (VLPs) efficiently induce temporary prophylactic activity through the induction of neutralizing antibodies; however, VLPs that can provide prophylactic as well as therapeutic properties for longer periods of time are needed. For this purpose, we generated a novel HPV 16 L1-based chimeric virus-like particle (cVLP) produced in plants that contains a string of T-cell epitopes from HPV 16 E6 and E7 fused to its C-terminus. In the present study, we analyzed the persistence of specific IgG antibodies with neutralizing activity induced by immunization with these cVLPs, as well as their therapeutic potential in a tumor model of C57BL/6 mice. We observed that these cVLPs induced persistent IgG antibodies for over 12 months, with reactivity and neutralizing activity for VLPs composed of only the HPV-16 L1 protein. Efficient protection for long periods of time and inhibition of tumor growth induced by TC-1 tumor cells expressing HPV-16 E6/E7 oncoproteins, as well as significant tumor reduction (57 %), were observed in mice immunized with these cVLPs. Finally, we discuss the possibility that chimeric particles of the type described in this work may be the basis for developing HPV prophylactic and therapeutic vaccines with high efficacy.
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47 HPV-16 E6/E7 oncoproteins
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50 IgG antibodies
51 L1
52 L1 protein
53 TC-1 tumor cells
54 VLPs
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56 antibodies
57 basis
58 cell epitopes
59 cells
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62 efficacy
63 efficient protection
64 elicits
65 epitopes
66 growth
67 high efficacy
68 immunization
69 induction
70 inhibition
71 long period
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73 model
74 months
75 mouse model
76 oncoprotein
77 particles
78 period
79 persistence
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90 reactivity
91 reduction
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94 strings
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97 therapeutic efficacy
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101 time
102 tumor cells
103 tumor growth
104 tumor model
105 tumor mouse model
106 tumor reduction
107 types
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