Phylogenetic analysis of bovine leukemia viruses isolated in South America reveals diversification in seven distinct genotypes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-04

AUTHORS

Gonzalo Moratorio, Gonzalo Obal, Ana Dubra, Agustín Correa, Sergio Bianchi, Alejandro Buschiazzo, Juan Cristina, Otto Pritsch

ABSTRACT

Bovine leukaemia virus (BLV) is an oncogenic member of the genus Deltaretrovirus of the family Retroviridae. Recent studies revealed that BLV strains can be classified into six different genotypes and raised the possibility that another genotype may exist. In order to gain insight into the degree of genetic variability of BLV strains circulating in the South American region, a phylogenetic analysis was performed using gp51 env gene sequences. The results of these studies revealed the presence of seven BLV genotypes in this geographic region and the suitability of partial gp51 env gene sequences for phylogenetic inference. A significant number of amino acid substitutions found in BLV strains isolated in South America map to the second neutralization domain of gp51. A 3D molecular model of BLV gp51 revealed that these substitutions are located on the surface of the molecule. This may provide a selective advantage to overcome immune host neutralization. More... »

PAGES

481-489

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00705-010-0606-3

DOI

http://dx.doi.org/10.1007/s00705-010-0606-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048435793

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20169372


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

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curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00705-010-0606-3'

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curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00705-010-0606-3'

Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00705-010-0606-3'


 

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308 Unidad de Proteínas Recombinantes, Institut Pasteur de Montevideo, Mataojo 2020, 11400, Montevideo, Uruguay
309 rdf:type schema:Organization
 




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