Significance of eukaryotic translation elongation factor 1A in tobacco mosaic virus infection View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-12-11

AUTHORS

Yasuyuki Yamaji, Keitaro Sakurai, Koji Hamada, Ken Komatsu, Johji Ozeki, Akiko Yoshida, Atsushi Yoshii, Takumi Shimizu, Shigetou Namba, Tadaaki Hibi

ABSTRACT

Eukaryotic translation elongation factor 1A (eEF1A) has been shown to interact with both the viral RNA-dependent RNA polymerase and the 3′-terminal genomic RNA of tobacco mosaic virus (TMV). In this study, we demonstrated that the down-regulation of eEF1A mRNA levels by virus-induced gene silencing using potato virus X vector dramatically reduced the accumulation of TMV RNA and the spread of TMV infection. The translation activity of the eEF1A-silenced Nicotiana benthamiana leaves was not severely affected. Collectively, these results suggest an essential role of eEF1A in TMV infection. More... »

PAGES

263-268

Journal

TITLE

Archives of Virology

ISSUE

2

VOLUME

155

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00705-009-0571-x

DOI

http://dx.doi.org/10.1007/s00705-009-0571-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036876624

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20012112


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