HCV genotype 1b chimeric replicon with NS5B of JFH-1 exhibited resistance to cyclosporine A View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-10

AUTHORS

Ken-ichi Abe, Masanori Ikeda, Yasuo Ariumi, Hiromichi Dansako, Takaji Wakita, Nobuyuki Kato

ABSTRACT

Cyclosporine A (CsA) is a well-characterized anti-HCV reagent. Recently it was reported that the genotype 2a JFH-1 strain was more resistant than genotype 1 HCV strains to CsA in a cell culture system. However, the JFH-1 responsible region for the resistance to CsA remains unclear. It was also demonstrated that in genotype 1b HCVs, NS5B interacts with cyclophilin (CyP). To clarify whether or not NS5B of JFH-1 is significant for CsA resistance, we developed a chimeric replicon with NS5B of JFH-1 in the genotype 1b backbone. The chimeric replicon was more resistant to CsA than the parental genotype 1b replicon. Furthermore, reduction of CyPA had a greater effect on HCV RNA replication and sensitivity to CsA than reduction of CyPB. Here, we demonstrated that NS5B of JFH-1 contributed to this strain's CsA-resistant phenotype. NS5B and CyPA are significant for determining HCV's sensitivity to CsA. More... »

PAGES

1671

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00705-009-0502-x

DOI

http://dx.doi.org/10.1007/s00705-009-0502-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014327621

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19779801


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