Different pattern of reduction of striatal dopamine reuptake sites in Alzheimer's disease and ageing View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-07

AUTHORS

N. Kemppainen, P. Marjamäki, M. Röyttä, J. O. Rinne

ABSTRACT

Summary. Striatal dopamine reuptake sites were studied in brain samples from 14 Alzheimer's disease (AD) patients. A cocaine analogue, [3H]CFT (WIN 35,428, 2β-carbomethoxy-3β-(4-fluorophenyl)-tropane) was used as a radioligand to determine the number of [3H]CFT binding sites (Bmax) and their dissociation constant (Kd). In patients with AD the reduction in [3H]CFT binding in the putamen was about 50% compared to age-matched controls. In the caudate nucleus the reduction was about 33%. Thus, the putamen was more severely affected. No change was observed in Kd values between AD patients and controls.Brain samples from 37 healthy controls (aged from 8 to 91 years) were used to study the changes in striatal [3H]CFT binding with increasing age. The Bmax of [3H]CFT uptake was reduced both in the putamen and in the caudate nucleus. The average decline per decade was greater in the caudate nucleus (7.3%) than in the putamen (5.5%). In conclusion, the pattern of changes in AD is different from that seen during normal ageing, which seems to affect more severely the caudate nucleus than the putamen. More... »

PAGES

827-836

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s007020170032

DOI

http://dx.doi.org/10.1007/s007020170032

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021976730

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11515748


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