Cortisol levels, motor, cognitive and behavioral symptoms in Parkinson’s disease: a systematic review View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

Nayron Medeiros Soares, Gabriela Magalhães Pereira, Vivian Altmann, Rosa Maria Martins de Almeida, Carlos R. M. Rieder

ABSTRACT

Parkinson's disease (PD) is a progressive and multifactorial neurodegenerative disease. It has been suggested that a dysregulation of the hypothalamic-pituitary-adrenal axis (HPA) occurs in PD. Furthermore, this dysregulation may be involved in triggering, exacerbation or progression of disease. The objective of this study was to systematically review the literature regarding cortisol levels and their relation with motor, cognitive and behavioral symptoms in patients with PD. A systematic search was performed in PubMed and Embase databases, according to PRISMA norms. Twenty-one studies were included, which evaluated baseline levels of cortisol and motor, cognitive, behavioral symptoms, drugs administration or deep brain stimulation to PD treatment. Sample size ranged from 7 to 249 individuals. In 14 studies that assessed cortisol levels in PD patients, seven showed elevation of cortisol levels. In relation to symptomatology, high levels of cortisol were associated with worst functional scores evaluated by UPDRS, depression and behavior in risk preference. Medication interactions showed an influence on the regulation of cortisol release, mainly, conventional drugs used in the PD's treatment, such as levodopa. The results found in this review point to a possible relationship between cortisol levels and symptoms in PD, indicating that an HPA axis dysfunction related to cortisol level occurs in PD. More... »

PAGES

219-232

References to SciGraph publications

  • 1986-06. Effect of hypoglycaemia, TRH and levodopa on plasma growth hormone, prolactin, thyrotropin and cortisol in Parkinson's disease before and during therapy in JOURNAL OF NEUROLOGY
  • 1991-02. Plasma profiles of adrenocorticotropic hormone, cortisol, growth hormone and prolactin in patients with untreated parkinson's disease in JOURNAL OF NEUROLOGY
  • 2014-08. A further update on the role of excitotoxicity in the pathogenesis of Parkinson’s disease in JOURNAL OF NEURAL TRANSMISSION
  • 2015-12. Randomized controlled expressive writing pilot in individuals with Parkinson’s disease and their caregivers in BMC PSYCHOLOGY
  • 2007-03. Acute levodopa administration reduces cortisol release in patients with Parkinson’s disease in JOURNAL OF NEURAL TRANSMISSION
  • 2008-09. Epidemiology of Parkinson’s disease in JOURNAL OF NEUROLOGY
  • 2009-04. Cell death pathways in Parkinson’s disease: proximal triggers, distal effectors, and final steps in APOPTOSIS
  • 2017-08. Epidemiology of Parkinson’s disease in JOURNAL OF NEURAL TRANSMISSION
  • 2018-04. Differential Alterations in Metabolism and Proteolysis-Related Proteins in Human Parkinson’s Disease Substantia Nigra in NEUROTOXICITY RESEARCH
  • 2001-04. Chronic Cold Stress Reduces the Spontaneous Activity of Ventral Tegmental Dopamine Neurons in NEUROPSYCHOPHARMACOLOGY
  • 2010-11. Therapeutic Efficacy of the Neuroprotective Plant Adaptogen in Neurodegenerative Disease (Parkinson’s Disease as an Example) in BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00702-018-1947-4

    DOI

    http://dx.doi.org/10.1007/s00702-018-1947-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1107912238

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30374595


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre", 
              "id": "https://www.grid.ac/institutes/grid.412344.4", 
              "name": [
                "Medical Science Post Graduation Program, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2400, Porto Alegre, RS, Brazil", 
                "Institute of Psychology, Laboratory of Psychology, Neuroscience and Behavior (LPNeC), Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2600, Porto Alegre, RS, Brazil", 
                "Hospital de Clinicas de Porto Alegre (HCPA), Rua Ramiro Barcelos, 2350, Porto Alegre, RS, Brazil", 
                "Federal University of Health Science of Porto Alegre (UFCSPA), Rua Sarmento Leite, 245, Porto Alegre, RS, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Soares", 
            "givenName": "Nayron Medeiros", 
            "id": "sg:person.014321672207.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014321672207.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Federal University of Rio Grande do Sul", 
              "id": "https://www.grid.ac/institutes/grid.8532.c", 
              "name": [
                "Institute of Basic Health Sciences, Federal University of Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos, 2400, Porto Alegre, RS, Brazil", 
                "Institute of Psychology, Laboratory of Psychology, Neuroscience and Behavior (LPNeC), Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2600, Porto Alegre, RS, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pereira", 
            "givenName": "Gabriela Magalh\u00e3es", 
            "id": "sg:person.016512213607.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016512213607.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital de Cl\u00ednicas de Porto Alegre", 
              "id": "https://www.grid.ac/institutes/grid.414449.8", 
              "name": [
                "Institute of Biosciences, Federal University of Rio Grande do Sul, Av. Bento Gon\u00e7alves, 9500, Porto Alegre, RS, Brazil", 
                "Hospital de Clinicas de Porto Alegre (HCPA), Rua Ramiro Barcelos, 2350, Porto Alegre, RS, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Altmann", 
            "givenName": "Vivian", 
            "id": "sg:person.0674753602.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674753602.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Federal University of Rio Grande do Sul", 
              "id": "https://www.grid.ac/institutes/grid.8532.c", 
              "name": [
                "Institute of Psychology, Laboratory of Psychology, Neuroscience and Behavior (LPNeC), Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2600, Porto Alegre, RS, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "de Almeida", 
            "givenName": "Rosa Maria Martins", 
            "id": "sg:person.011653437142.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011653437142.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre", 
              "id": "https://www.grid.ac/institutes/grid.412344.4", 
              "name": [
                "Medical Science Post Graduation Program, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2400, Porto Alegre, RS, Brazil", 
                "Hospital de Clinicas de Porto Alegre (HCPA), Rua Ramiro Barcelos, 2350, Porto Alegre, RS, Brazil", 
                "Federal University of Health Science of Porto Alegre (UFCSPA), Rua Sarmento Leite, 245, Porto Alegre, RS, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rieder", 
            "givenName": "Carlos R. M.", 
            "id": "sg:person.013321036774.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013321036774.51"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.3389/fnana.2015.00091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000876512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1590/0004-282x20140228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001803919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00319704", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002889396", 
              "https://doi.org/10.1007/bf00319704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00319704", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002889396", 
              "https://doi.org/10.1007/bf00319704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0896-6273(03)00568-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003090951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000097237", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006120650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fnins.2015.00507", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006989893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fnagi.2014.00318", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007446683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.psyneuen.2014.12.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008815961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jneuroim.2010.12.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011721811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/s0893-133x(00)00188-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011988633", 
              "https://doi.org/10.1016/s0893-133x(00)00188-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000119394", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015037575"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000343808", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018056669"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mds.20244", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019420286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40359-015-0101-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020666776", 
              "https://doi.org/10.1186/s40359-015-0101-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00702-006-0552-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021681796", 
              "https://doi.org/10.1007/s00702-006-0552-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00702-006-0552-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021681796", 
              "https://doi.org/10.1007/s00702-006-0552-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.wnf.0000240954.72186.91", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022297288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.wnf.0000240954.72186.91", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022297288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.wnf.0000240954.72186.91", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022297288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1468-1331.2008.02058.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024195447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yebeh.2004.07.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026887757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-510x(76)90253-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028489765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-510x(76)90253-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028489765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jnnp.2011.245746", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029196424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00314421", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031352530", 
              "https://doi.org/10.1007/bf00314421"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00314421", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031352530", 
              "https://doi.org/10.1007/bf00314421"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jnnp-2013-305911", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031451017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00702-013-1149-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031882644", 
              "https://doi.org/10.1007/s00702-013-1149-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mds.22589", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032406884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mds.22589", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032406884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamaneurol.2014.65", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034933177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00415-008-5004-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035542489", 
              "https://doi.org/10.1007/s00415-008-5004-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00415-008-5004-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035542489", 
              "https://doi.org/10.1007/s00415-008-5004-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0133002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037496223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pmed.1000097", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037575666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fnins.2015.00169", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040781336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2016/6391686", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040793588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10517-010-1023-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041791930", 
              "https://doi.org/10.1007/s10517-010-1023-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10517-010-1023-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041791930", 
              "https://doi.org/10.1007/s10517-010-1023-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biopsych.2006.11.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042144625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0098682", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042843028"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.psyneuen.2015.10.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043042608"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mehy.2008.06.036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044020399"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0197-4580(97)80309-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045216429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10495-008-0309-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047557517", 
              "https://doi.org/10.1007/s10495-008-0309-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10495-008-0309-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047557517", 
              "https://doi.org/10.1007/s10495-008-0309-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000439532", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050069489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/brb3.556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050960594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mds.23732", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051317156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002826-200303000-00005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051995690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1176/appi.psy.51.6.474", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063510743"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/2042018810380214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064084180"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/2042018810380214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064084180"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/1389202914666131210213042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069178696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5455/medarh.2016.70.445-448", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072873293"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078441960", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079127175", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00702-017-1686-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083404003", 
              "https://doi.org/10.1007/s00702-017-1686-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00702-017-1686-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083404003", 
              "https://doi.org/10.1007/s00702-017-1686-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4103/0366-6999.204920", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085040218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.psyneuen.2017.07.240", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090683836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1590/0004-282x20170091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091202664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.25099", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092753777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12640-017-9843-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099704732", 
              "https://doi.org/10.1007/s12640-017-9843-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1590/0004-282x20180091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107723702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1590/0004-282x20180091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107723702"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-03", 
        "datePublishedReg": "2019-03-01", 
        "description": "Parkinson's disease (PD) is a progressive and multifactorial neurodegenerative disease. It has been suggested that a dysregulation of the hypothalamic-pituitary-adrenal axis (HPA) occurs in PD. Furthermore, this dysregulation may be involved in triggering, exacerbation or progression of disease. The objective of this study was to systematically review the literature regarding cortisol levels and their relation with motor, cognitive and behavioral symptoms in patients with PD. A systematic search was performed in PubMed and Embase databases, according to PRISMA norms. Twenty-one studies were included, which evaluated baseline levels of cortisol and motor, cognitive, behavioral symptoms, drugs administration or deep brain stimulation to PD treatment. Sample size ranged from 7 to 249 individuals. In 14 studies that assessed cortisol levels in PD patients, seven showed elevation of cortisol levels. In relation to symptomatology, high levels of cortisol were associated with worst functional scores evaluated by UPDRS, depression and behavior in risk preference. Medication interactions showed an influence on the regulation of cortisol release, mainly, conventional drugs used in the PD's treatment, such as levodopa. The results found in this review point to a possible relationship between cortisol levels and symptoms in PD, indicating that an HPA axis dysfunction related to cortisol level occurs in PD.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00702-018-1947-4", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1312227", 
            "issn": [
              "0300-9564", 
              "1435-1463"
            ], 
            "name": "Journal of Neural Transmission", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "126"
          }
        ], 
        "name": "Cortisol levels, motor, cognitive and behavioral symptoms in Parkinson\u2019s disease: a systematic review", 
        "pagination": "219-232", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "ffbf5d9ff47ba65091efe0913ef3103f338859b07a6bedcb0e0ac05413670c64"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30374595"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9702341"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00702-018-1947-4"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1107912238"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00702-018-1947-4", 
          "https://app.dimensions.ai/details/publication/pub.1107912238"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:59", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130823_00000006.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs00702-018-1947-4"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00702-018-1947-4'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00702-018-1947-4'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00702-018-1947-4'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00702-018-1947-4'


     

    This table displays all metadata directly associated to this object as RDF triples.

    279 TRIPLES      21 PREDICATES      83 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00702-018-1947-4 schema:about anzsrc-for:11
    2 anzsrc-for:1109
    3 schema:author N3327b29cd8654d74beef40a80b981e9c
    4 schema:citation sg:pub.10.1007/bf00314421
    5 sg:pub.10.1007/bf00319704
    6 sg:pub.10.1007/s00415-008-5004-3
    7 sg:pub.10.1007/s00702-006-0552-0
    8 sg:pub.10.1007/s00702-013-1149-z
    9 sg:pub.10.1007/s00702-017-1686-y
    10 sg:pub.10.1007/s10495-008-0309-3
    11 sg:pub.10.1007/s10517-010-1023-z
    12 sg:pub.10.1007/s12640-017-9843-5
    13 sg:pub.10.1016/s0893-133x(00)00188-3
    14 sg:pub.10.1186/s40359-015-0101-4
    15 https://app.dimensions.ai/details/publication/pub.1078441960
    16 https://app.dimensions.ai/details/publication/pub.1079127175
    17 https://doi.org/10.1001/jamaneurol.2014.65
    18 https://doi.org/10.1002/ana.25099
    19 https://doi.org/10.1002/brb3.556
    20 https://doi.org/10.1002/mds.20244
    21 https://doi.org/10.1002/mds.22589
    22 https://doi.org/10.1002/mds.23732
    23 https://doi.org/10.1016/0022-510x(76)90253-7
    24 https://doi.org/10.1016/j.biopsych.2006.11.033
    25 https://doi.org/10.1016/j.jneuroim.2010.12.001
    26 https://doi.org/10.1016/j.mehy.2008.06.036
    27 https://doi.org/10.1016/j.psyneuen.2014.12.001
    28 https://doi.org/10.1016/j.psyneuen.2015.10.006
    29 https://doi.org/10.1016/j.psyneuen.2017.07.240
    30 https://doi.org/10.1016/j.yebeh.2004.07.008
    31 https://doi.org/10.1016/s0197-4580(97)80309-0
    32 https://doi.org/10.1016/s0896-6273(03)00568-3
    33 https://doi.org/10.1097/00002826-200303000-00005
    34 https://doi.org/10.1097/01.wnf.0000240954.72186.91
    35 https://doi.org/10.1111/j.1468-1331.2008.02058.x
    36 https://doi.org/10.1136/jnnp-2013-305911
    37 https://doi.org/10.1136/jnnp.2011.245746
    38 https://doi.org/10.1155/2016/6391686
    39 https://doi.org/10.1159/000097237
    40 https://doi.org/10.1159/000119394
    41 https://doi.org/10.1159/000343808
    42 https://doi.org/10.1159/000439532
    43 https://doi.org/10.1176/appi.psy.51.6.474
    44 https://doi.org/10.1177/2042018810380214
    45 https://doi.org/10.1371/journal.pmed.1000097
    46 https://doi.org/10.1371/journal.pone.0098682
    47 https://doi.org/10.1371/journal.pone.0133002
    48 https://doi.org/10.1590/0004-282x20140228
    49 https://doi.org/10.1590/0004-282x20170091
    50 https://doi.org/10.1590/0004-282x20180091
    51 https://doi.org/10.2174/1389202914666131210213042
    52 https://doi.org/10.3389/fnagi.2014.00318
    53 https://doi.org/10.3389/fnana.2015.00091
    54 https://doi.org/10.3389/fnins.2015.00169
    55 https://doi.org/10.3389/fnins.2015.00507
    56 https://doi.org/10.4103/0366-6999.204920
    57 https://doi.org/10.5455/medarh.2016.70.445-448
    58 schema:datePublished 2019-03
    59 schema:datePublishedReg 2019-03-01
    60 schema:description Parkinson's disease (PD) is a progressive and multifactorial neurodegenerative disease. It has been suggested that a dysregulation of the hypothalamic-pituitary-adrenal axis (HPA) occurs in PD. Furthermore, this dysregulation may be involved in triggering, exacerbation or progression of disease. The objective of this study was to systematically review the literature regarding cortisol levels and their relation with motor, cognitive and behavioral symptoms in patients with PD. A systematic search was performed in PubMed and Embase databases, according to PRISMA norms. Twenty-one studies were included, which evaluated baseline levels of cortisol and motor, cognitive, behavioral symptoms, drugs administration or deep brain stimulation to PD treatment. Sample size ranged from 7 to 249 individuals. In 14 studies that assessed cortisol levels in PD patients, seven showed elevation of cortisol levels. In relation to symptomatology, high levels of cortisol were associated with worst functional scores evaluated by UPDRS, depression and behavior in risk preference. Medication interactions showed an influence on the regulation of cortisol release, mainly, conventional drugs used in the PD's treatment, such as levodopa. The results found in this review point to a possible relationship between cortisol levels and symptoms in PD, indicating that an HPA axis dysfunction related to cortisol level occurs in PD.
    61 schema:genre research_article
    62 schema:inLanguage en
    63 schema:isAccessibleForFree false
    64 schema:isPartOf N405bca2ff1f442fdbe49cd815874f6cb
    65 N5e53259b078945fb8ae55bed72a67d2e
    66 sg:journal.1312227
    67 schema:name Cortisol levels, motor, cognitive and behavioral symptoms in Parkinson’s disease: a systematic review
    68 schema:pagination 219-232
    69 schema:productId N04110fe3183c4354824fb7207ba135f2
    70 N4fbf3574b044416886646b23307540d9
    71 Nc01f9f4be49e4424b904cef78a4cb56c
    72 Nf0327784ae4c40c985458940d36243fb
    73 Nf5118aa8a4d94fd2b1139398b4b2ee05
    74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107912238
    75 https://doi.org/10.1007/s00702-018-1947-4
    76 schema:sdDatePublished 2019-04-11T13:59
    77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    78 schema:sdPublisher N4de8adeb8fac4b4287fe0a34c51abe04
    79 schema:url https://link.springer.com/10.1007%2Fs00702-018-1947-4
    80 sgo:license sg:explorer/license/
    81 sgo:sdDataset articles
    82 rdf:type schema:ScholarlyArticle
    83 N04110fe3183c4354824fb7207ba135f2 schema:name dimensions_id
    84 schema:value pub.1107912238
    85 rdf:type schema:PropertyValue
    86 N3327b29cd8654d74beef40a80b981e9c rdf:first sg:person.014321672207.22
    87 rdf:rest N5e5de31b1ba54608b32e20812804bb3a
    88 N405bca2ff1f442fdbe49cd815874f6cb schema:issueNumber 3
    89 rdf:type schema:PublicationIssue
    90 N4de8adeb8fac4b4287fe0a34c51abe04 schema:name Springer Nature - SN SciGraph project
    91 rdf:type schema:Organization
    92 N4fbf3574b044416886646b23307540d9 schema:name pubmed_id
    93 schema:value 30374595
    94 rdf:type schema:PropertyValue
    95 N5d17d202337348348036d954792b7d35 rdf:first sg:person.011653437142.42
    96 rdf:rest N6002199854fe40d18481b4bc5ebe593e
    97 N5e53259b078945fb8ae55bed72a67d2e schema:volumeNumber 126
    98 rdf:type schema:PublicationVolume
    99 N5e5de31b1ba54608b32e20812804bb3a rdf:first sg:person.016512213607.45
    100 rdf:rest N98ae3080ec984d929127301c9f1848e7
    101 N6002199854fe40d18481b4bc5ebe593e rdf:first sg:person.013321036774.51
    102 rdf:rest rdf:nil
    103 N98ae3080ec984d929127301c9f1848e7 rdf:first sg:person.0674753602.96
    104 rdf:rest N5d17d202337348348036d954792b7d35
    105 Nc01f9f4be49e4424b904cef78a4cb56c schema:name doi
    106 schema:value 10.1007/s00702-018-1947-4
    107 rdf:type schema:PropertyValue
    108 Nf0327784ae4c40c985458940d36243fb schema:name nlm_unique_id
    109 schema:value 9702341
    110 rdf:type schema:PropertyValue
    111 Nf5118aa8a4d94fd2b1139398b4b2ee05 schema:name readcube_id
    112 schema:value ffbf5d9ff47ba65091efe0913ef3103f338859b07a6bedcb0e0ac05413670c64
    113 rdf:type schema:PropertyValue
    114 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    115 schema:name Medical and Health Sciences
    116 rdf:type schema:DefinedTerm
    117 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    118 schema:name Neurosciences
    119 rdf:type schema:DefinedTerm
    120 sg:journal.1312227 schema:issn 0300-9564
    121 1435-1463
    122 schema:name Journal of Neural Transmission
    123 rdf:type schema:Periodical
    124 sg:person.011653437142.42 schema:affiliation https://www.grid.ac/institutes/grid.8532.c
    125 schema:familyName de Almeida
    126 schema:givenName Rosa Maria Martins
    127 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011653437142.42
    128 rdf:type schema:Person
    129 sg:person.013321036774.51 schema:affiliation https://www.grid.ac/institutes/grid.412344.4
    130 schema:familyName Rieder
    131 schema:givenName Carlos R. M.
    132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013321036774.51
    133 rdf:type schema:Person
    134 sg:person.014321672207.22 schema:affiliation https://www.grid.ac/institutes/grid.412344.4
    135 schema:familyName Soares
    136 schema:givenName Nayron Medeiros
    137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014321672207.22
    138 rdf:type schema:Person
    139 sg:person.016512213607.45 schema:affiliation https://www.grid.ac/institutes/grid.8532.c
    140 schema:familyName Pereira
    141 schema:givenName Gabriela Magalhães
    142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016512213607.45
    143 rdf:type schema:Person
    144 sg:person.0674753602.96 schema:affiliation https://www.grid.ac/institutes/grid.414449.8
    145 schema:familyName Altmann
    146 schema:givenName Vivian
    147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674753602.96
    148 rdf:type schema:Person
    149 sg:pub.10.1007/bf00314421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031352530
    150 https://doi.org/10.1007/bf00314421
    151 rdf:type schema:CreativeWork
    152 sg:pub.10.1007/bf00319704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002889396
    153 https://doi.org/10.1007/bf00319704
    154 rdf:type schema:CreativeWork
    155 sg:pub.10.1007/s00415-008-5004-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035542489
    156 https://doi.org/10.1007/s00415-008-5004-3
    157 rdf:type schema:CreativeWork
    158 sg:pub.10.1007/s00702-006-0552-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021681796
    159 https://doi.org/10.1007/s00702-006-0552-0
    160 rdf:type schema:CreativeWork
    161 sg:pub.10.1007/s00702-013-1149-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1031882644
    162 https://doi.org/10.1007/s00702-013-1149-z
    163 rdf:type schema:CreativeWork
    164 sg:pub.10.1007/s00702-017-1686-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1083404003
    165 https://doi.org/10.1007/s00702-017-1686-y
    166 rdf:type schema:CreativeWork
    167 sg:pub.10.1007/s10495-008-0309-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047557517
    168 https://doi.org/10.1007/s10495-008-0309-3
    169 rdf:type schema:CreativeWork
    170 sg:pub.10.1007/s10517-010-1023-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1041791930
    171 https://doi.org/10.1007/s10517-010-1023-z
    172 rdf:type schema:CreativeWork
    173 sg:pub.10.1007/s12640-017-9843-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099704732
    174 https://doi.org/10.1007/s12640-017-9843-5
    175 rdf:type schema:CreativeWork
    176 sg:pub.10.1016/s0893-133x(00)00188-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011988633
    177 https://doi.org/10.1016/s0893-133x(00)00188-3
    178 rdf:type schema:CreativeWork
    179 sg:pub.10.1186/s40359-015-0101-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020666776
    180 https://doi.org/10.1186/s40359-015-0101-4
    181 rdf:type schema:CreativeWork
    182 https://app.dimensions.ai/details/publication/pub.1078441960 schema:CreativeWork
    183 https://app.dimensions.ai/details/publication/pub.1079127175 schema:CreativeWork
    184 https://doi.org/10.1001/jamaneurol.2014.65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034933177
    185 rdf:type schema:CreativeWork
    186 https://doi.org/10.1002/ana.25099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092753777
    187 rdf:type schema:CreativeWork
    188 https://doi.org/10.1002/brb3.556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050960594
    189 rdf:type schema:CreativeWork
    190 https://doi.org/10.1002/mds.20244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019420286
    191 rdf:type schema:CreativeWork
    192 https://doi.org/10.1002/mds.22589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032406884
    193 rdf:type schema:CreativeWork
    194 https://doi.org/10.1002/mds.23732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051317156
    195 rdf:type schema:CreativeWork
    196 https://doi.org/10.1016/0022-510x(76)90253-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028489765
    197 rdf:type schema:CreativeWork
    198 https://doi.org/10.1016/j.biopsych.2006.11.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042144625
    199 rdf:type schema:CreativeWork
    200 https://doi.org/10.1016/j.jneuroim.2010.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011721811
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.1016/j.mehy.2008.06.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044020399
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.1016/j.psyneuen.2014.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008815961
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.1016/j.psyneuen.2015.10.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043042608
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.1016/j.psyneuen.2017.07.240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090683836
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1016/j.yebeh.2004.07.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026887757
    211 rdf:type schema:CreativeWork
    212 https://doi.org/10.1016/s0197-4580(97)80309-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045216429
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1016/s0896-6273(03)00568-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003090951
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1097/00002826-200303000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051995690
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1097/01.wnf.0000240954.72186.91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022297288
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1111/j.1468-1331.2008.02058.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024195447
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1136/jnnp-2013-305911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031451017
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1136/jnnp.2011.245746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029196424
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1155/2016/6391686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040793588
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1159/000097237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006120650
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1159/000119394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015037575
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1159/000343808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018056669
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1159/000439532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050069489
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1176/appi.psy.51.6.474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063510743
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1177/2042018810380214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064084180
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1371/journal.pmed.1000097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037575666
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1371/journal.pone.0098682 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042843028
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1371/journal.pone.0133002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037496223
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1590/0004-282x20140228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001803919
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1590/0004-282x20170091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091202664
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1590/0004-282x20180091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107723702
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.2174/1389202914666131210213042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069178696
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.3389/fnagi.2014.00318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007446683
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.3389/fnana.2015.00091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000876512
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.3389/fnins.2015.00169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040781336
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.3389/fnins.2015.00507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006989893
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.4103/0366-6999.204920 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085040218
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.5455/medarh.2016.70.445-448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072873293
    265 rdf:type schema:CreativeWork
    266 https://www.grid.ac/institutes/grid.412344.4 schema:alternateName Universidade Federal de Ciências da Saúde de Porto Alegre
    267 schema:name Federal University of Health Science of Porto Alegre (UFCSPA), Rua Sarmento Leite, 245, Porto Alegre, RS, Brazil
    268 Hospital de Clinicas de Porto Alegre (HCPA), Rua Ramiro Barcelos, 2350, Porto Alegre, RS, Brazil
    269 Institute of Psychology, Laboratory of Psychology, Neuroscience and Behavior (LPNeC), Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2600, Porto Alegre, RS, Brazil
    270 Medical Science Post Graduation Program, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2400, Porto Alegre, RS, Brazil
    271 rdf:type schema:Organization
    272 https://www.grid.ac/institutes/grid.414449.8 schema:alternateName Hospital de Clínicas de Porto Alegre
    273 schema:name Hospital de Clinicas de Porto Alegre (HCPA), Rua Ramiro Barcelos, 2350, Porto Alegre, RS, Brazil
    274 Institute of Biosciences, Federal University of Rio Grande do Sul, Av. Bento Gonçalves, 9500, Porto Alegre, RS, Brazil
    275 rdf:type schema:Organization
    276 https://www.grid.ac/institutes/grid.8532.c schema:alternateName Federal University of Rio Grande do Sul
    277 schema:name Institute of Basic Health Sciences, Federal University of Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos, 2400, Porto Alegre, RS, Brazil
    278 Institute of Psychology, Laboratory of Psychology, Neuroscience and Behavior (LPNeC), Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2600, Porto Alegre, RS, Brazil
    279 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...