Visual versus automated analysis of [I-123]FP-CIT SPECT scans in parkinsonism View Full Text


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Article Info

DATE

2016-06-20

AUTHORS

Elina Mäkinen, Juho Joutsa, Jarkko Johansson, Maija Mäki, Marko Seppänen, Valtteri Kaasinen

ABSTRACT

The clinical evaluation of dopamine transporter (DAT) SPECT scans typically relies on visual analysis in combination with an automated semi-quantitative method. The interpretation of the results may be difficult in cases that show disagreement between the two methods on the borderline of abnormality. The frequency and clinical characteristics of such cases are unclear. Automated semi-quantitative analyses and independent visual analyses by two experienced nuclear medicine physicians and four inexperienced raters were performed for 120 patients with clinically uncertain parkinsonism scanned with brain [I-123]FP-CIT SPECT. Agreement was evaluated with kappa statistics. The clinical characteristics of patients who had discrepant findings between the two analysis methods were investigated. The expert raters outperformed nonexperts in terms of agreement between visual and automated analyses (κ = 0.66, 0.72 vs. 0.23–0.54) and between raters (κ = 0.81 vs. 0.44–0.63). Twelve patients showed discrepant findings between the visual and automated analyses. These patients were older compared to other patients (p = 0.023), had 17.6 % lower mean striatal tracer binding compared to normal scans (p = 0.003) and 62.7 % higher compared to abnormal scans (p < 0.001). After a minimum of 4.5 years of clinical follow-up, none of these patients developed neurodegenerative parkinsonism. Clinical DAT SPECT scans show discrepancies between visual and automated analyses in 10 % of cases. The patients with discrepant findings are older, show normal to slightly abnormal tracer binding, and importantly, do not develop neurodegenerative parkinsonism syndromes. Visual analyses by experienced raters are reliable, but the diagnostic accuracy in discrepant cases can be improved by an automated method. More... »

PAGES

1309-1318

References to SciGraph publications

  • 2015-12-16. Predictors of normal and abnormal outcome in clinical brain dopamine transporter imaging in JOURNAL OF NEURAL TRANSMISSION
  • 2006-12. Comparative analysis of visual and semi-quantitative assessment of striatal [123I]FP-CIT-SPET binding in Parkinson's disease in NEUROLOGICAL SCIENCES
  • 2010-12-02. SPECT imaging evaluation in movement disorders: far beyond visual assessment in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2012-11-16. European multicentre database of healthy controls for [123I]FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2015-07-02. Dopamine transporter imaging in essential tremor with and without parkinsonian features in JOURNAL OF NEURAL TRANSMISSION
  • 2012-03-03. SPECT study with I-123-Ioflupane (DaTSCAN) in patients with essential tremor. Is there any correlation with Parkinson’s disease? in ANNALS OF NUCLEAR MEDICINE
  • 2016-01-18. Implementation of the European multicentre database of healthy controls for [123I]FP-CIT SPECT increases diagnostic accuracy in patients with clinically uncertain parkinsonian syndromes in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2011-07-13. Visual assessment of dopaminergic degeneration pattern in 123I-FP-CIT SPECT differentiates patients with atypical parkinsonian syndromes and idiopathic Parkinson's disease in JOURNAL OF NEUROLOGY
  • 2014-05-28. Differences in striatal dopamine transporter density between tremor dominant and non-tremor Parkinson’s disease in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00702-016-1586-6

    DOI

    http://dx.doi.org/10.1007/s00702-016-1586-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022644220

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27324804


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