Increase expression of α-synuclein in aged human brain associated with neuromelanin accumulation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-11

AUTHORS

Qi Xuan, Sheng-Li Xu, De-Hong Lu, Shun Yu, Ming Zhou, Kenji Uéda, Ye-Qing Cui, Bo-Yang Zhang, Piu Chan

ABSTRACT

Although the increased prevalence of Parkinson's disease (PD) with aging suggests that aging processes predispose dopamine neurons to degeneration, the mechanism involved remains unknown. Dopamine neurons contain significant amounts of neuromelanin, and the amount of neuromelanin increases with aging. In the present study, age-related changes in the number of nigral neurons expressing neuromelanin (NM), α-synuclein, and tyrosine hydroxylase (TH) were stereologically analyzed in the postmortem brains of 28 healthy humans with an age range of 17-84 years. Stereological counting of NM content, α-synuclein content, and TH immunoreactivity revealed significant accumulation of NM and α-synuclein in neurons during the aging process. In cells containing a large amount of NM, α-synuclein-immunoreactive cells in aged individuals outnumbered those of younger individuals. In non-NM cells, the α-synuclein expression profile was similar across age groups. Furthermore, TH-immunoreactive neurons decreased significantly with aging, which was associated with accumulation of NM and α-synuclein. Our results suggest that age related accumulation of NM might induce α-synuclein over-expression and thereby make dopamine neurons more vulnerable to injuries. More... »

PAGES

1575-1583

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00702-011-0636-3

DOI

http://dx.doi.org/10.1007/s00702-011-0636-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033607014

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21461961


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

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N-Triples is a line-based linked data format ideal for batch operations.

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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00702-011-0636-3'


 

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301 Department of Pathology, Xuanwu Hospital of the Capital University of Medical Sciences, 45 Changchun Street, 100053, Beijing, China
302 rdf:type schema:Organization
303 https://www.grid.ac/institutes/grid.417113.1 schema:alternateName Tokyo Institute of Psychiatry
304 schema:name Department of Neurobiology and the Sino-Japan Joint Laboratory of Neurodegenerative diseases, Institute of Geriatrics of Beijing, Xuanwu Hospital of the Capital University of Medical Sciences, Key Laboratory for Neurodegenerative Disease of Ministry of Education, 45 Changchun Street, 100053, Beijing, China
305 Division of Psychobiology, Tokyo Institute of Psychiatry, 156-8585, Tokyo, Japan
306 rdf:type schema:Organization
 




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