α-Synuclein increases U251 cells vulnerability to hydrogen peroxide by disrupting calcium homeostasis View Full Text


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Article Info

DATE

2011-02-20

AUTHORS

Zhengxin Ying, Fankai Lin, Weihong Gu, Yang Su, Abida Arshad, Hong Qing, Yulin Deng

ABSTRACT

Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by glial cytoplasmic inclusions containing insoluble α-synuclein. Since Ca2+ plays an important role in cell degeneration, [Ca2+]i in α-synuclein-overexpressed human glioma cells was analyzed by Fura-2 fluorometry. Overexpression of α-synuclein increased the basal level of [Ca2+]i, and a higher Ca2+ response to hydrogen peroxide was further observed. The effect that α-synuclein overexpression caused U251 cells to be more vulnerable to hydrogen peroxide was eliminated by Ca2+ chelator BAPTA-AM or transient receptor potential channels blocker SKF 96365 but not by L-type Ca2+ channel blocker nimodipine. These findings suggest that the dysregulation of cellular Ca2+ homeostasis caused by α-synuclein under oxidative stress may contribute to the glial cell death in MSA. More... »

PAGES

1165-1172

References to SciGraph publications

  • 2003-07. Regulation of cell death: the calcium–apoptosis link in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2005-01-22. The role of α-synuclein in the pathogenesis of multiple system atrophy in ACTA NEUROPATHOLOGICA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00702-011-0596-7

    DOI

    http://dx.doi.org/10.1007/s00702-011-0596-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019337174

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21336954


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