Screening for anorexia nervosa via measurement of serum leptin levels View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-01-22

AUTHORS

M. Föcker, N. Timmesfeld, S. Scherag, K. Bühren, M. Langkamp, A. Dempfle, E. M. Sheridan, M. de Zwaan, C. Fleischhaker, W. Herzog, K. Egberts, S. Zipfel, B. Herpertz-Dahlmann, J. Hebebrand

ABSTRACT

Due to their sub-normally low fat mass, leptin levels in patients with acute anorexia nervosa (AN) are well below reference levels for age and sex-matched controls. This hypoleptinemia entails endocrinological and behavioral characteristics observed in AN patients during starvation. We aimed to study the appropriateness of hypoleptinemia as a diagnostic marker for AN by assessing sensitivity, specificity and likelihood ratios for different referral serum leptin levels for predicting anorexia nervosa and healthy leanness. For prediction, we additionally generated a score based on a multivariate logistic model including body mass index (BMI; kg/m²) and leptin level. For this purpose, we measured leptin levels in 74 female patients with acute AN upon admission for inpatient or outpatient treatment. Adolescent and adult patients were recruited according to DSM-IV criteria from two multi-center studies. Additionally, leptin levels were measured in 65 female healthy, lean students. Mean serum leptin level was significantly decreased in patients with AN compared to underweight controls (0.87 ± 0.90 vs. 6.43 ± 3.55 μg/L, p < 0.001). Leptin predicted AN independently of BMI; we confirmed a cutoff value in the range of 2 μg/L as having both high specificity and sensitivity. Hypoleptinemia represents a state marker of acute AN and is useful for a laboratory-based diagnostic screening. More... »

PAGES

571-578

Journal

TITLE

Journal of Neural Transmission

ISSUE

4

VOLUME

118

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00702-010-0551-z

DOI

http://dx.doi.org/10.1007/s00702-010-0551-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038135348

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21258826


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27 schema:description Due to their sub-normally low fat mass, leptin levels in patients with acute anorexia nervosa (AN) are well below reference levels for age and sex-matched controls. This hypoleptinemia entails endocrinological and behavioral characteristics observed in AN patients during starvation. We aimed to study the appropriateness of hypoleptinemia as a diagnostic marker for AN by assessing sensitivity, specificity and likelihood ratios for different referral serum leptin levels for predicting anorexia nervosa and healthy leanness. For prediction, we additionally generated a score based on a multivariate logistic model including body mass index (BMI; kg/m²) and leptin level. For this purpose, we measured leptin levels in 74 female patients with acute AN upon admission for inpatient or outpatient treatment. Adolescent and adult patients were recruited according to DSM-IV criteria from two multi-center studies. Additionally, leptin levels were measured in 65 female healthy, lean students. Mean serum leptin level was significantly decreased in patients with AN compared to underweight controls (0.87 ± 0.90 vs. 6.43 ± 3.55 μg/L, p < 0.001). Leptin predicted AN independently of BMI; we confirmed a cutoff value in the range of 2 μg/L as having both high specificity and sensitivity. Hypoleptinemia represents a state marker of acute AN and is useful for a laboratory-based diagnostic screening.
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34 DSM-IV criteria
35 acute AN
36 acute anorexia nervosa
37 admission
38 adult patients
39 age
40 anorexia nervosa
41 appropriateness
42 behavioral characteristics
43 body mass index
44 characteristics
45 control
46 criteria
47 cutoff value
48 diagnostic marker
49 diagnostic screening
50 fat mass
51 female patients
52 high specificity
53 hypoleptinemia
54 index
55 inpatients
56 lean students
57 leanness
58 leptin
59 leptin levels
60 levels
61 likelihood ratio
62 logistic model
63 lower fat mass
64 markers
65 mass
66 mass index
67 measurements
68 model
69 multi-center study
70 multivariate logistic model
71 nervosa
72 outpatient treatment
73 patients
74 prediction
75 purpose
76 range
77 ratio
78 reference levels
79 scores
80 screening
81 sensitivity
82 serum leptin levels
83 sex-matched controls
84 specificity
85 starvation
86 state marker
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