Ontology type: schema:ScholarlyArticle
2009-10-29
AUTHORSDiana Elinos-Calderón, Yolanda Robledo-Arratia, Verónica Pérez-De La Cruz, Perla D. Maldonado, Sonia Galván-Arzate, José Pedraza-Chaverrí, Abel Santamaría
ABSTRACTThe functional preservation of nerve endings since the early stages of toxicity in a given damaging insult—either acute or chronic—by means of antioxidant and neuroprotective agents is a primary need to design therapeutic strategies for neurodegenerative disorders, with particular emphasis on those diseases with excitotoxic and depleted energy metabolism components. S-allylcysteine (SAC), a well-known antioxidant agent, was tested as a post-treatment in different in vitro and in vivo neurotoxic models. Quinolinic acid (QUIN) was used as a typical excitotoxic/pro-oxidant inducer, 3-nitropropionic acid (3-NP) was employed as a mitochondrial function inhibitor, and their combination (QUIN + 3-NP) was also evaluated in in vitro studies. For in vitro purposes, increasing concentrations of SAC (10–100 μM) were added to isolated brain synaptosomes at different times (1, 3 and 6 h) after the incubation with toxins (100 μM QUIN, 1 mM 3-NP or the combination of QUIN (21 μM) + 3-NP (166 μM). Thirty minutes later, lipid peroxidation (LP) and mitochondrial dysfunction (MD) were evaluated. For in vivo studies, SAC (100 mg/kg, i.p.) was given to QUIN- or 3-NP-striatally lesioned rats for 7 consecutive days (starting 120 min post-lesion). LP and MD were evaluated 7 days post-lesion in isolated striatal synaptosomes. Circling behavior was also assessed. Our results describe a differential pattern of protection achieved by SAC, mostly expressed in the 3-NP toxic model, in which nerve ending protection was found within the first hours (1 and 3) after the toxic insult started, supporting the concept that the ongoing oxidative damage and energy depletion can be treated during the first stages of neurotoxic events. More... »
PAGES35
http://scigraph.springernature.com/pub.10.1007/s00702-009-0299-5
DOIhttp://dx.doi.org/10.1007/s00702-009-0299-5
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