Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-11

AUTHORS

Kerstin U. Ludwig, Darina Roeske, Johannes Schumacher, Gerd Schulte-Körne, Inke R. König, Andreas Warnke, Ellen Plume, Andreas Ziegler, Helmut Remschmidt, Bertram Müller-Myhsok, Markus M. Nöthen, Per Hoffmann

ABSTRACT

The dyslexia susceptibility locus DYX2 (chr. 6p21-p22) harbours two candidate genes, DCDC2 and KIAA0319. In 2006, Harold et al. reported evidence for interaction between both genes. Having previously identified a risk haplotype for dyslexia in DCDC2, but not KIAA0319, in German families, we also tested for interaction between this risk haplotype and KIAA0319. We found a nominally significant association for the quantitative dimension "word reading", the core phenotype in the study of Harold et al., which may be considered as supportive evidence. More... »

PAGES

1587-1589

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00702-008-0124-6

DOI

http://dx.doi.org/10.1007/s00702-008-0124-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031253171

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18810304


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