Apolipoprotein E, angiotensin-converting enzyme and kallikrein gene polymorphisms and the risk of Alzheimer’s disease and vascular dementia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-10

AUTHORS

H. K. Wang, H. C. Fung, W. C. Hsu, Y. R. Wu, J. C. Lin, L. S. Ro, K. H. Chang, F. J. Hwu, Y. Hsu, S. Y. Huang, G. J. Lee-Chen, C. M. Chen

ABSTRACT

Lipoproteins and vascular factors may play roles in the development of Alzheimer's disease (AD) and/or vascular dementia (VaD). In this study, odd ratios (ORs) and 95% confidence intervals (CIs) for apolipoprotein E (APOE), angiotensin-converting enzyme (ACE), and kallikrein (KLK1) polymorphisms were computed to test their association with the disease by a case-control study. The risk of AD was significantly increased for individuals with APOE varepsilon4 allele (OR = 3.73, 95% CI = 2.38-5.98). The risk of AD was also significant for people with ACE DD genotype, D allele, or T-D haplotype [OR (95% CI) = 4.29 (1.96-10.23), 1.90 (1.35-2.70), or 2.91 (1.71-5.10), respectively]. The above association between ACE-VaD was also strong (p = 0.0012, 0.0050, 0.0007, respectively). Reporter constructs containing the -240 A or T allele displayed similar transcriptional activity in both HEK-293 and IMR-32 cells. Thus, another putative pathogenic marker that is linked with the Alu D allele might affect the risk of AD and VaD in Taiwan. More... »

PAGES

1499-1509

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00702-005-0424-z

DOI

http://dx.doi.org/10.1007/s00702-005-0424-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021288470

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16465461


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