Genetic alterations associated with malignant transformation of sporadic vestibular schwannoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-11-24

AUTHORS

Aril Løge Håvik, Ove Bruland, Hrvoje Miletic, Lars Poulsgaard, David Scheie, Kåre Fugleholm, Morten Lund-Johansen, Per-Morten Knappskog

ABSTRACT

IntroductionMalignant peripheral nerve sheath tumor of the vestibulocochlear nerve (VN-MPNST) is exceedingly rare and carries a poor prognosis. Little is known about its underlying genetics and in particular the process of malignant transformation. There is an ongoing debate on whether the transformation is initiated by ionizing radiation. We present here the analysis and comparison of two post-radiation VN-MPNST and one undergoing spontaneous transformation.MethodsFour tumors from three patients (radiation-naïve vestibular schwannoma before (VS) and after (VN-MPNST) malignant transformation in addition to two post-radiation VN-MPNST) were subjected to DNA whole-genome microarray and whole-exome sequencing and tumor-specific mutations were called. Mutational signatures were characterized using MuSiCa.ResultsThe tumor genomes were characterized predominantly by copy-number aberrations with 36–81% of the genome affected. Even the VS genome was grossly aberrated. The spontaneous malignant transformation was characterized by a near-total whole-genome doubling, disappearance of NF2 mutation and new mutations in three cancer-related genes (GNAQ, FOXO4 and PDGFRB). All tumors had homozygous loss of the tumor suppressor CDKN2A. Neither mutational signature nor copy number profile was associated with ionizing radiation.ConclusionThe VN-MPNST genome in our cases is characterized by large copy-number aberrations and homozygous deletion of CDKN2A. Our study demonstrates a VS with genetic alterations similar to its malignant counterpart, suggesting the existence of premalignant VS. No consistent mutational signature was associated with ionizing radiation. More... »

PAGES

343-352

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00701-021-05062-0

DOI

http://dx.doi.org/10.1007/s00701-021-05062-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1142910673

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34816314


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homozygote", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nerve Sheath Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuroma, Acoustic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Deletion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vestibulocochlear Nerve", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Clinical Medicine, University of Bergen, Bergen, Norway", 
          "id": "http://www.grid.ac/institutes/grid.7914.b", 
          "name": [
            "Department of Clinical Science, University of Bergen, Bergen, Norway", 
            "Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway", 
            "Department of Clinical Medicine, University of Bergen, Bergen, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "H\u00e5vik", 
        "givenName": "Aril L\u00f8ge", 
        "id": "sg:person.010755674103.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010755674103.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway", 
          "id": "http://www.grid.ac/institutes/grid.412008.f", 
          "name": [
            "Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bruland", 
        "givenName": "Ove", 
        "id": "sg:person.013547010254.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013547010254.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Haukeland University Hospital, Bergen, Norway", 
          "id": "http://www.grid.ac/institutes/grid.412008.f", 
          "name": [
            "Department of Pathology, Haukeland University Hospital, Bergen, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miletic", 
        "givenName": "Hrvoje", 
        "id": "sg:person.01033174143.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033174143.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurosurgery, Rigshospitalet, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Neurosurgery, Rigshospitalet, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Poulsgaard", 
        "givenName": "Lars", 
        "id": "sg:person.0763451717.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763451717.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Rigshospitalet, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Pathology, Rigshospitalet, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scheie", 
        "givenName": "David", 
        "id": "sg:person.01235576113.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235576113.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurosurgery, Rigshospitalet, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Neurosurgery, Rigshospitalet, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fugleholm", 
        "givenName": "K\u00e5re", 
        "id": "sg:person.01331301672.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331301672.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway", 
          "id": "http://www.grid.ac/institutes/grid.412008.f", 
          "name": [
            "Department of Clinical Medicine, University of Bergen, Bergen, Norway", 
            "Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lund-Johansen", 
        "givenName": "Morten", 
        "id": "sg:person.0652110624.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652110624.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway", 
          "id": "http://www.grid.ac/institutes/grid.412008.f", 
          "name": [
            "Department of Clinical Science, University of Bergen, Bergen, Norway", 
            "Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Knappskog", 
        "givenName": "Per-Morten", 
        "id": "sg:person.0635440674.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635440674.51"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ng.3116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028147277", 
          "https://doi.org/10.1038/ng.3116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-016-1540-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015632078", 
          "https://doi.org/10.1007/s00401-016-1540-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-020-03631-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1131238052", 
          "https://doi.org/10.1007/s11060-020-03631-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019307928", 
          "https://doi.org/10.1038/nbt.1754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12859-018-2234-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104554508", 
          "https://doi.org/10.1186/s12859-018-2234-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001578388", 
          "https://doi.org/10.1038/ncb2008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.2514", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000477771", 
          "https://doi.org/10.1038/nbt.2514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms12605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038683164", 
          "https://doi.org/10.1038/ncomms12605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep36158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043535995", 
          "https://doi.org/10.1038/srep36158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-009-0611-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002728880", 
          "https://doi.org/10.1007/s00401-009-0611-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.3095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010337120", 
          "https://doi.org/10.1038/ng.3095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature13561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053323056", 
          "https://doi.org/10.1038/nature13561"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-11-24", 
    "datePublishedReg": "2021-11-24", 
    "description": "IntroductionMalignant peripheral nerve sheath tumor of the vestibulocochlear nerve (VN-MPNST) is exceedingly rare and carries a poor prognosis. Little is known about its underlying genetics and in particular the process of malignant transformation. There is an ongoing debate on whether the transformation is initiated by ionizing radiation. We present here the analysis and comparison of two post-radiation VN-MPNST and one undergoing spontaneous transformation.MethodsFour tumors from three patients (radiation-na\u00efve vestibular schwannoma before (VS) and after (VN-MPNST) malignant transformation in addition to two post-radiation VN-MPNST) were subjected to DNA whole-genome microarray and whole-exome sequencing and tumor-specific mutations were called. Mutational signatures were characterized using MuSiCa.ResultsThe tumor genomes were characterized predominantly by copy-number aberrations with 36\u201381% of the genome affected. Even the VS genome was grossly aberrated. The spontaneous malignant transformation was characterized by a near-total whole-genome doubling, disappearance of NF2 mutation and new mutations in three cancer-related genes (GNAQ, FOXO4 and PDGFRB). All tumors had homozygous loss of the tumor suppressor CDKN2A. Neither mutational signature nor copy number profile was associated with ionizing radiation.ConclusionThe VN-MPNST genome in our cases is characterized by large copy-number aberrations and homozygous deletion of CDKN2A. Our study demonstrates a VS with genetic alterations similar to its malignant counterpart, suggesting the existence of premalignant VS. No consistent mutational signature was associated with ionizing radiation.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00701-021-05062-0", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1412990", 
        "issn": [
          "0001-6268", 
          "0942-0940"
        ], 
        "name": "Acta Neurochirurgica", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "164"
      }
    ], 
    "keywords": [
      "malignant transformation", 
      "peripheral nerve sheath tumors", 
      "mutational signatures", 
      "copy number aberrations", 
      "nerve sheath tumors", 
      "sporadic vestibular schwannoma", 
      "genetic alterations", 
      "spontaneous malignant transformation", 
      "tumor-specific mutations", 
      "whole-exome sequencing", 
      "sheath tumors", 
      "vestibulocochlear nerve", 
      "poor prognosis", 
      "vestibular schwannoma", 
      "cancer-related genes", 
      "malignant counterparts", 
      "large copy-number aberrations", 
      "tumors", 
      "NF2 mutations", 
      "homozygous loss", 
      "whole-genome microarrays", 
      "copy number profiles", 
      "homozygous deletion", 
      "CDKN2A.", 
      "tumor genomes", 
      "new mutations", 
      "alterations", 
      "mutations", 
      "nerve", 
      "prognosis", 
      "patients", 
      "schwannoma", 
      "aberrations", 
      "whole-genome doubling", 
      "spontaneous transformation", 
      "microarray", 
      "number profiles", 
      "ongoing debate", 
      "deletion", 
      "sequencing", 
      "cases", 
      "genes", 
      "study", 
      "disappearance", 
      "loss", 
      "profile", 
      "radiation", 
      "genetics", 
      "doubling", 
      "signatures", 
      "genome", 
      "Vs", 
      "comparison", 
      "analysis", 
      "counterparts", 
      "debate", 
      "transformation", 
      "process", 
      "existence", 
      "musica"
    ], 
    "name": "Genetic alterations associated with malignant transformation of sporadic vestibular schwannoma", 
    "pagination": "343-352", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1142910673"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00701-021-05062-0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "34816314"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00701-021-05062-0", 
      "https://app.dimensions.ai/details/publication/pub.1142910673"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-10T10:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_904.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00701-021-05062-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00701-021-05062-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00701-021-05062-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00701-021-05062-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00701-021-05062-0'


 

This table displays all metadata directly associated to this object as RDF triples.

263 TRIPLES      22 PREDICATES      105 URIs      85 LITERALS      14 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00701-021-05062-0 schema:about N02fa3439eea64b67a847d622f4c56977
2 N5cb691f1333b43ca8e92c2717be394d3
3 N6b5e1476ef634fc1821984ba6df97e4f
4 N7e55f0da85454a16bdbde009fd6d8e84
5 N9ef61bb68685488ab9c63553eb7e1048
6 Na06c917dda914e7897591f9f7a5c3066
7 Nc003aa6ed56f46219cb409b363eb7725
8 anzsrc-for:11
9 anzsrc-for:1112
10 schema:author Nc266bfa1ea364d848a67d562760ba05b
11 schema:citation sg:pub.10.1007/s00401-009-0611-3
12 sg:pub.10.1007/s00401-016-1540-6
13 sg:pub.10.1007/s11060-020-03631-4
14 sg:pub.10.1038/nature13561
15 sg:pub.10.1038/nbt.1754
16 sg:pub.10.1038/nbt.2514
17 sg:pub.10.1038/ncb2008
18 sg:pub.10.1038/ncomms12605
19 sg:pub.10.1038/ng.3095
20 sg:pub.10.1038/ng.3116
21 sg:pub.10.1038/srep36158
22 sg:pub.10.1186/s12859-018-2234-y
23 schema:datePublished 2021-11-24
24 schema:datePublishedReg 2021-11-24
25 schema:description IntroductionMalignant peripheral nerve sheath tumor of the vestibulocochlear nerve (VN-MPNST) is exceedingly rare and carries a poor prognosis. Little is known about its underlying genetics and in particular the process of malignant transformation. There is an ongoing debate on whether the transformation is initiated by ionizing radiation. We present here the analysis and comparison of two post-radiation VN-MPNST and one undergoing spontaneous transformation.MethodsFour tumors from three patients (radiation-naïve vestibular schwannoma before (VS) and after (VN-MPNST) malignant transformation in addition to two post-radiation VN-MPNST) were subjected to DNA whole-genome microarray and whole-exome sequencing and tumor-specific mutations were called. Mutational signatures were characterized using MuSiCa.ResultsThe tumor genomes were characterized predominantly by copy-number aberrations with 36–81% of the genome affected. Even the VS genome was grossly aberrated. The spontaneous malignant transformation was characterized by a near-total whole-genome doubling, disappearance of NF2 mutation and new mutations in three cancer-related genes (GNAQ, FOXO4 and PDGFRB). All tumors had homozygous loss of the tumor suppressor CDKN2A. Neither mutational signature nor copy number profile was associated with ionizing radiation.ConclusionThe VN-MPNST genome in our cases is characterized by large copy-number aberrations and homozygous deletion of CDKN2A. Our study demonstrates a VS with genetic alterations similar to its malignant counterpart, suggesting the existence of premalignant VS. No consistent mutational signature was associated with ionizing radiation.
26 schema:genre article
27 schema:inLanguage en
28 schema:isAccessibleForFree true
29 schema:isPartOf N41c45ba9c9a14baf89b510209e54801d
30 N73136e9e129d416097b1f0847cd3fa34
31 sg:journal.1412990
32 schema:keywords CDKN2A.
33 NF2 mutations
34 Vs
35 aberrations
36 alterations
37 analysis
38 cancer-related genes
39 cases
40 comparison
41 copy number aberrations
42 copy number profiles
43 counterparts
44 debate
45 deletion
46 disappearance
47 doubling
48 existence
49 genes
50 genetic alterations
51 genetics
52 genome
53 homozygous deletion
54 homozygous loss
55 large copy-number aberrations
56 loss
57 malignant counterparts
58 malignant transformation
59 microarray
60 musica
61 mutational signatures
62 mutations
63 nerve
64 nerve sheath tumors
65 new mutations
66 number profiles
67 ongoing debate
68 patients
69 peripheral nerve sheath tumors
70 poor prognosis
71 process
72 profile
73 prognosis
74 radiation
75 schwannoma
76 sequencing
77 sheath tumors
78 signatures
79 spontaneous malignant transformation
80 spontaneous transformation
81 sporadic vestibular schwannoma
82 study
83 transformation
84 tumor genomes
85 tumor-specific mutations
86 tumors
87 vestibular schwannoma
88 vestibulocochlear nerve
89 whole-exome sequencing
90 whole-genome doubling
91 whole-genome microarrays
92 schema:name Genetic alterations associated with malignant transformation of sporadic vestibular schwannoma
93 schema:pagination 343-352
94 schema:productId N31d5b506b5f34d7cba27f73d42293d46
95 N96bd95a48a4547d2894fbbf0de44ed60
96 Ne031f3ed3ad247f1a491d581a20765dd
97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1142910673
98 https://doi.org/10.1007/s00701-021-05062-0
99 schema:sdDatePublished 2022-05-10T10:31
100 schema:sdLicense https://scigraph.springernature.com/explorer/license/
101 schema:sdPublisher Nf6213a2b9bd840dabe0f1526e28898f0
102 schema:url https://doi.org/10.1007/s00701-021-05062-0
103 sgo:license sg:explorer/license/
104 sgo:sdDataset articles
105 rdf:type schema:ScholarlyArticle
106 N0286b8145bda4cab9536cbc63eb7b465 rdf:first sg:person.0763451717.74
107 rdf:rest N64709e2ddc85465baaf427116cc5a2c4
108 N02fa3439eea64b67a847d622f4c56977 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Nerve Sheath Neoplasms
110 rdf:type schema:DefinedTerm
111 N1ef92998b7454f3791c1e2c1f6cf8bf9 rdf:first sg:person.01033174143.94
112 rdf:rest N0286b8145bda4cab9536cbc63eb7b465
113 N31d5b506b5f34d7cba27f73d42293d46 schema:name dimensions_id
114 schema:value pub.1142910673
115 rdf:type schema:PropertyValue
116 N41c45ba9c9a14baf89b510209e54801d schema:volumeNumber 164
117 rdf:type schema:PublicationVolume
118 N422afb37afcc4ea0b8b814c881fa0da3 rdf:first sg:person.0635440674.51
119 rdf:rest rdf:nil
120 N4bd18ac172214ab191b37349e7d097a1 rdf:first sg:person.013547010254.03
121 rdf:rest N1ef92998b7454f3791c1e2c1f6cf8bf9
122 N5cb691f1333b43ca8e92c2717be394d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Homozygote
124 rdf:type schema:DefinedTerm
125 N64709e2ddc85465baaf427116cc5a2c4 rdf:first sg:person.01235576113.96
126 rdf:rest N9b9584a4d7694f0c9521bf8f8e0f8a15
127 N6b5e1476ef634fc1821984ba6df97e4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Humans
129 rdf:type schema:DefinedTerm
130 N73136e9e129d416097b1f0847cd3fa34 schema:issueNumber 2
131 rdf:type schema:PublicationIssue
132 N7e55f0da85454a16bdbde009fd6d8e84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Neuroma, Acoustic
134 rdf:type schema:DefinedTerm
135 N96bd95a48a4547d2894fbbf0de44ed60 schema:name doi
136 schema:value 10.1007/s00701-021-05062-0
137 rdf:type schema:PropertyValue
138 N9ac041ce87e84759af68fb76088a7a96 rdf:first sg:person.0652110624.59
139 rdf:rest N422afb37afcc4ea0b8b814c881fa0da3
140 N9b9584a4d7694f0c9521bf8f8e0f8a15 rdf:first sg:person.01331301672.58
141 rdf:rest N9ac041ce87e84759af68fb76088a7a96
142 N9ef61bb68685488ab9c63553eb7e1048 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Mutation
144 rdf:type schema:DefinedTerm
145 Na06c917dda914e7897591f9f7a5c3066 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Vestibulocochlear Nerve
147 rdf:type schema:DefinedTerm
148 Nc003aa6ed56f46219cb409b363eb7725 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Sequence Deletion
150 rdf:type schema:DefinedTerm
151 Nc266bfa1ea364d848a67d562760ba05b rdf:first sg:person.010755674103.45
152 rdf:rest N4bd18ac172214ab191b37349e7d097a1
153 Ne031f3ed3ad247f1a491d581a20765dd schema:name pubmed_id
154 schema:value 34816314
155 rdf:type schema:PropertyValue
156 Nf6213a2b9bd840dabe0f1526e28898f0 schema:name Springer Nature - SN SciGraph project
157 rdf:type schema:Organization
158 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
159 schema:name Medical and Health Sciences
160 rdf:type schema:DefinedTerm
161 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
162 schema:name Oncology and Carcinogenesis
163 rdf:type schema:DefinedTerm
164 sg:journal.1412990 schema:issn 0001-6268
165 0942-0940
166 schema:name Acta Neurochirurgica
167 schema:publisher Springer Nature
168 rdf:type schema:Periodical
169 sg:person.01033174143.94 schema:affiliation grid-institutes:grid.412008.f
170 schema:familyName Miletic
171 schema:givenName Hrvoje
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033174143.94
173 rdf:type schema:Person
174 sg:person.010755674103.45 schema:affiliation grid-institutes:grid.7914.b
175 schema:familyName Håvik
176 schema:givenName Aril Løge
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010755674103.45
178 rdf:type schema:Person
179 sg:person.01235576113.96 schema:affiliation grid-institutes:None
180 schema:familyName Scheie
181 schema:givenName David
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235576113.96
183 rdf:type schema:Person
184 sg:person.01331301672.58 schema:affiliation grid-institutes:None
185 schema:familyName Fugleholm
186 schema:givenName Kåre
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331301672.58
188 rdf:type schema:Person
189 sg:person.013547010254.03 schema:affiliation grid-institutes:grid.412008.f
190 schema:familyName Bruland
191 schema:givenName Ove
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013547010254.03
193 rdf:type schema:Person
194 sg:person.0635440674.51 schema:affiliation grid-institutes:grid.412008.f
195 schema:familyName Knappskog
196 schema:givenName Per-Morten
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635440674.51
198 rdf:type schema:Person
199 sg:person.0652110624.59 schema:affiliation grid-institutes:grid.412008.f
200 schema:familyName Lund-Johansen
201 schema:givenName Morten
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652110624.59
203 rdf:type schema:Person
204 sg:person.0763451717.74 schema:affiliation grid-institutes:None
205 schema:familyName Poulsgaard
206 schema:givenName Lars
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763451717.74
208 rdf:type schema:Person
209 sg:pub.10.1007/s00401-009-0611-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002728880
210 https://doi.org/10.1007/s00401-009-0611-3
211 rdf:type schema:CreativeWork
212 sg:pub.10.1007/s00401-016-1540-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015632078
213 https://doi.org/10.1007/s00401-016-1540-6
214 rdf:type schema:CreativeWork
215 sg:pub.10.1007/s11060-020-03631-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1131238052
216 https://doi.org/10.1007/s11060-020-03631-4
217 rdf:type schema:CreativeWork
218 sg:pub.10.1038/nature13561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053323056
219 https://doi.org/10.1038/nature13561
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/nbt.1754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019307928
222 https://doi.org/10.1038/nbt.1754
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/nbt.2514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000477771
225 https://doi.org/10.1038/nbt.2514
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/ncb2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001578388
228 https://doi.org/10.1038/ncb2008
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/ncomms12605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038683164
231 https://doi.org/10.1038/ncomms12605
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/ng.3095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010337120
234 https://doi.org/10.1038/ng.3095
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/ng.3116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028147277
237 https://doi.org/10.1038/ng.3116
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/srep36158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043535995
240 https://doi.org/10.1038/srep36158
241 rdf:type schema:CreativeWork
242 sg:pub.10.1186/s12859-018-2234-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1104554508
243 https://doi.org/10.1186/s12859-018-2234-y
244 rdf:type schema:CreativeWork
245 grid-institutes:None schema:alternateName Department of Neurosurgery, Rigshospitalet, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark
246 Department of Pathology, Rigshospitalet, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark
247 schema:name Department of Neurosurgery, Rigshospitalet, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark
248 Department of Pathology, Rigshospitalet, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark
249 rdf:type schema:Organization
250 grid-institutes:grid.412008.f schema:alternateName Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
251 Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway
252 Department of Pathology, Haukeland University Hospital, Bergen, Norway
253 schema:name Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
254 Department of Clinical Medicine, University of Bergen, Bergen, Norway
255 Department of Clinical Science, University of Bergen, Bergen, Norway
256 Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway
257 Department of Pathology, Haukeland University Hospital, Bergen, Norway
258 rdf:type schema:Organization
259 grid-institutes:grid.7914.b schema:alternateName Department of Clinical Medicine, University of Bergen, Bergen, Norway
260 schema:name Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
261 Department of Clinical Medicine, University of Bergen, Bergen, Norway
262 Department of Clinical Science, University of Bergen, Bergen, Norway
263 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...