Aggressive pituitary neuroendocrine tumors: current practices, controversies, and perspectives, on behalf of the EANS skull base section View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-08-08

AUTHORS

Sam Ng, Mahmoud Messerer, Julien Engelhardt, Michaël Bruneau, Jan Frederick Cornelius, Luigi Maria Cavallo, Giulia Cossu, Sebastien Froelich, Torstein R. Meling, Dimitrios Paraskevopoulos, Henry W. S. Schroeder, Marcos Tatagiba, Idoya Zazpe, Moncef Berhouma, Roy T. Daniel, Edward R. Laws, Engelbert Knosp, Michael Buchfelder, Henri Dufour, Stéphane Gaillard, Timothée Jacquesson, Emmanuel Jouanneau

ABSTRACT

Aggressive pituitary neuroendocrine tumors (APT) account for 10% of pituitary tumors. Their management is a rapidly evolving field of clinical research and has led pituitary teams to shift toward a neuro-oncological-like approach. The new terminology “Pituitary neuroendocrine tumors” (PitNet) that was recently proposed to replace “pituitary adenomas” reflects this change of paradigm. In this narrative review, we aim to provide a state of the art of actual knowledge, controversies, and recommendations in the management of APT. We propose an overview of current prognostic markers, including the recent five-tiered clinicopathological classification. We further establish and discuss the following recommendations from a neurosurgical perspective: (i) surgery and multi-staged surgeries (without or with parasellar resection in symptomatic patients) should be discussed at each stage of the disease, because it may potentialize adjuvant medical therapies; (ii) temozolomide is effective in most patients, although 30% of patients are non-responders and the optimal timeline to initiate and interrupt this treatment remains questionable; (iii) some patients with selected clinicopathological profiles may benefit from an earlier local radiotherapy and/or chemotherapy; (iv) novel therapies such as VEGF-targeted therapies and anti-CTLA-4/anti-PD1 immunotherapies are promising and should be discussed as 2nd or 3rd line of treatment. Finally, whether neurosurgeons have to operate on “pituitary adenomas” or “PitNets,” their role and expertise remain crucial at each stage of the disease, prompting our community to deal with evolving concepts and therapeutic resources. More... »

PAGES

3131-3142

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  • Journal

    TITLE

    Acta Neurochirurgica

    ISSUE

    11

    VOLUME

    163

    Author Affiliations

  • Department of Neurosurgery, Montpellier University Medical Center, Montpellier, France
  • Department of Neurosurgery, Department of Neuroscience, Centre Hospitalier Universitaire Vaudois, University Hospital Lausanne, Lausanne, Switzerland
  • Department of Neurosurgery, Centre Hospitalo-Universitaire de Bordeaux, Bordeaux, France
  • Department of Neurosurgery, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Laarbeeklaan, Brussels, Belgium
  • Department of Neurosurgery, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany
  • Department of Neurosurgery, University Hospital of Naples Federico II, Napoli, NA, Italy
  • Department of Neurosurgery, Lariboisière Hospital, Université Paris Diderot, Paris, France
  • Department of Neurosurgery, University Hospital of Geneva, Geneva, Switzerland
  • Department of Neurosurgery, Barts Health NHS Trust, St. Bartholomew’s and The Royal London Hospital, London, UK
  • Department of Neurosurgery, University Medicine Greifswald, Greifswald, Germany
  • Department of Neurosurgery, University Hospital Tübingen, Tübingen, Germany
  • Department of Neurosurgery, Complejo Hospitalario de Navarra, Pamplona, Spain
  • Vascular and Neuro-Oncological Surgical Departement, Hopital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France
  • Pituitary and Neuroendocrine Center, Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
  • Department of Neurosurgery, Medical University of Vienna, Vienna, Austria
  • Department of Neurosurgery, University of Erlangen-Nürnberg, Erlangen, Germany
  • Department of Neurosurgery, Hôpital de La Timone, Assistance Publique-Hôpitaux de Marseille, Marseille, France
  • Department of Neurosurgery, Pitié-Salpétrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
  • Skull Base and Pituitary Neurosurgical Department, Hopital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00701-021-04953-6

    DOI

    http://dx.doi.org/10.1007/s00701-021-04953-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1140280352

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34365544


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