Pharmacological management of post-traumatic seizures in adults: current practice patterns in the UK and the Republic of Ireland View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-03

AUTHORS

Harry Mee, Angelos G. Kolias, Aswin Chari, Ari Ercole, Fiona Lecky, Carole Turner, Catrin Tudur-Smith, Jonathan Coles, Fahim Anwar, Antonio Belli, Mark Manford, Timothy Ham, Catherine McMahon, Diederik Bulters, Chris Uff, John S. Duncan, Mark H. Wilson, Anthony G. Marson, Peter J. Hutchinson

ABSTRACT

BACKGROUND: Patient selection for seizure prophylaxis after traumatic brain injury (TBI) and duration of anti-epileptic drug treatment for patients with early post-traumatic seizures (PTS), remain plagued with uncertainty. In early 2017, a collaborative group of neurosurgeons, neurologists, neurointensive care and rehabilitation medicine physicians was formed in the UK with the aim of assessing variability in current practice and gauging the degree of uncertainty to inform the design of future studies. Here we present the results of a survey of clinicians managing patients with TBI in the UK and Ireland. MATERIALS AND METHODS: An online survey was developed and piloted. Following approval by the Academic Committee of the Society of British Neurological Surgeons, it was distributed via appropriate electronic mailing lists. RESULTS: One hundred and seventeen respondents answered the questionnaire, predominantly neurosurgeons (76%) from 30 (of 32) trauma-receiving hospitals in the UK and Ireland. Fifty-three percent of respondents do not routinely use seizure prophylaxis, but 38% prescribe prophylaxis for one week. Sixty percent feel there is uncertainty regarding the use of seizure prophylaxis, and 71% would participate in further research to address this question. Sixty-two percent of respondents use levetiracetam for treatment of seizures during the acute phase, and 42% continued for a total of 3 months. Overall, 90% were uncertain about the duration of treatment for seizures, and 78% would participate in further research to address this question. CONCLUSION: The survey results demonstrate the variation in practice and uncertainty in both described aspects of management of patients who have suffered a TBI. The majority of respondents would want to participate in future research to help try and address this critical issue, and this shows the importance and relevance of these two clinical questions. More... »

PAGES

457-464

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00701-018-3683-9

DOI

http://dx.doi.org/10.1007/s00701-018-3683-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107341092

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30276544


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Addenbrooke's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.120073.7", 
          "name": [
            "Department of Clinical Neurosciences, University of Cambridge & Addenbrooke\u2019s Hospital, Cambridge, UK", 
            "Surgery theme, Cambridge Clinical Trials Unit, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mee", 
        "givenName": "Harry", 
        "id": "sg:person.015712627754.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015712627754.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Addenbrooke's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.120073.7", 
          "name": [
            "Department of Clinical Neurosciences, University of Cambridge & Addenbrooke\u2019s Hospital, Cambridge, UK", 
            "Surgery theme, Cambridge Clinical Trials Unit, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kolias", 
        "givenName": "Angelos G.", 
        "id": "sg:person.0632330025.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632330025.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal London Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416041.6", 
          "name": [
            "Department of Neurosurgery, Royal London Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chari", 
        "givenName": "Aswin", 
        "id": "sg:person.01136462120.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136462120.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Addenbrooke's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.120073.7", 
          "name": [
            "Neurosciences Critical Care Unit and Division of Anaesthesia, University of Cambridge & Addenbrooke\u2019s Hospital, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ercole", 
        "givenName": "Ari", 
        "id": "sg:person.012277144331.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012277144331.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sheffield", 
          "id": "https://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "School of Health and Related Research, University of Sheffield, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lecky", 
        "givenName": "Fiona", 
        "id": "sg:person.01046534236.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046534236.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Addenbrooke's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.120073.7", 
          "name": [
            "Department of Clinical Neurosciences, University of Cambridge & Addenbrooke\u2019s Hospital, Cambridge, UK", 
            "Surgery theme, Cambridge Clinical Trials Unit, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Turner", 
        "givenName": "Carole", 
        "id": "sg:person.01010366215.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010366215.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Liverpool", 
          "id": "https://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "Department of Biostatistics, University of Liverpool, Merseyside, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tudur-Smith", 
        "givenName": "Catrin", 
        "id": "sg:person.01261374732.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261374732.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Addenbrooke's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.120073.7", 
          "name": [
            "Neurosciences Critical Care Unit and Division of Anaesthesia, University of Cambridge & Addenbrooke\u2019s Hospital, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coles", 
        "givenName": "Jonathan", 
        "id": "sg:person.01021135720.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021135720.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Addenbrooke's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.120073.7", 
          "name": [
            "Department of Clinical Neurosciences, University of Cambridge & Addenbrooke\u2019s Hospital, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Anwar", 
        "givenName": "Fahim", 
        "id": "sg:person.0636127113.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636127113.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Queen Elizabeth Hospital Birmingham", 
          "id": "https://www.grid.ac/institutes/grid.415490.d", 
          "name": [
            "Department of Neurosurgery, Queen Elizabeth Hospital, Birmingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Belli", 
        "givenName": "Antonio", 
        "id": "sg:person.0673623751.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673623751.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Addenbrooke's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.120073.7", 
          "name": [
            "Department of Clinical Neurosciences, University of Cambridge & Addenbrooke\u2019s Hospital, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Manford", 
        "givenName": "Mark", 
        "id": "sg:person.01145653654.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145653654.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Addenbrooke's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.120073.7", 
          "name": [
            "Department of Clinical Neurosciences, University of Cambridge & Addenbrooke\u2019s Hospital, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ham", 
        "givenName": "Timothy", 
        "id": "sg:person.014134741707.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014134741707.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Walton Centre", 
          "id": "https://www.grid.ac/institutes/grid.416928.0", 
          "name": [
            "Department of Neurosurgery, The Walton Centre, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McMahon", 
        "givenName": "Catherine", 
        "id": "sg:person.01014411234.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014411234.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Southampton General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.123047.3", 
          "name": [
            "Department of Neurosurgery, University Hospital Southampton, Southampton, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bulters", 
        "givenName": "Diederik", 
        "id": "sg:person.01274163146.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274163146.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal London Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416041.6", 
          "name": [
            "Department of Neurosurgery, Royal London Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uff", 
        "givenName": "Chris", 
        "id": "sg:person.011162567770.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011162567770.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Duncan", 
        "givenName": "John S.", 
        "id": "sg:person.013101301440.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013101301440.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Imperial College London", 
          "id": "https://www.grid.ac/institutes/grid.7445.2", 
          "name": [
            "Imperial Neurotrauma Centre, Department of Surgery & Cancer, Imperial College, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wilson", 
        "givenName": "Mark H.", 
        "id": "sg:person.01072421523.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072421523.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Liverpool", 
          "id": "https://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marson", 
        "givenName": "Anthony G.", 
        "id": "sg:person.01174075734.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174075734.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Addenbrooke's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.120073.7", 
          "name": [
            "Department of Clinical Neurosciences, University of Cambridge & Addenbrooke\u2019s Hospital, Cambridge, UK", 
            "Surgery theme, Cambridge Clinical Trials Unit, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hutchinson", 
        "givenName": "Peter J.", 
        "id": "sg:person.013407653317.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013407653317.93"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejm199008233230801", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004278701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/epi.13470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012917488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1528-1157.44.s10.4.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014111243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12028-009-9304-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023684260", 
          "https://doi.org/10.1007/s12028-009-9304-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12028-009-9304-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023684260", 
          "https://doi.org/10.1007/s12028-009-9304-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd009900.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036877113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1528-1167.2012.03612.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049522550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1535-7511.2005.00056.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052897271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1535-7511.2005.00056.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052897271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000125184.88797.62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064345968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000125184.88797.62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064345968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000125184.88797.62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064345968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5698/1535-7597-15.2.94", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073075420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5698/1535-7597-15.2.94", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073075420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(17)30371-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092557000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(17)30371-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092557000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-018-2000-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103231296", 
          "https://doi.org/10.1186/s13054-018-2000-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-018-2000-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103231296", 
          "https://doi.org/10.1186/s13054-018-2000-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-018-2000-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103231296", 
          "https://doi.org/10.1186/s13054-018-2000-6"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-03", 
    "datePublishedReg": "2019-03-01", 
    "description": "BACKGROUND: Patient selection for seizure prophylaxis after traumatic brain injury (TBI) and\u00a0duration of anti-epileptic drug treatment\u00a0for patients with early post-traumatic seizures (PTS), remain plagued with uncertainty. In early 2017, a collaborative group of neurosurgeons, neurologists, neurointensive care and rehabilitation medicine physicians was formed in the UK with the aim of assessing variability in current practice and gauging the degree of uncertainty to inform the design of future studies. Here we present the results of a survey of clinicians managing patients with TBI in the UK and Ireland.\nMATERIALS AND METHODS: An online survey was developed and piloted. Following approval by the Academic Committee of the Society of British Neurological Surgeons, it was distributed via appropriate electronic mailing lists.\nRESULTS: One hundred and seventeen respondents answered the questionnaire, predominantly neurosurgeons (76%) from 30 (of 32) trauma-receiving hospitals in the UK and Ireland. Fifty-three percent of respondents do not routinely use seizure prophylaxis, but 38% prescribe prophylaxis for one week. Sixty percent feel there is uncertainty regarding the use of seizure prophylaxis, and 71% would participate in further research to address this question. Sixty-two percent of respondents use levetiracetam for treatment of seizures during the acute phase, and 42% continued for a total of 3\u00a0months. Overall, 90% were uncertain about the duration of treatment for seizures, and 78% would participate in further research to address this question.\nCONCLUSION: The survey results demonstrate the variation in practice and uncertainty in both described aspects of management of patients who have suffered a TBI. The majority of respondents would want to participate in future research to help try and address this critical issue, and this shows the importance and relevance of these two clinical questions.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00701-018-3683-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3795404", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1356888", 
        "issn": [
          "0001-6268", 
          "0942-0940"
        ], 
        "name": "Acta Neurochirurgica", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "161"
      }
    ], 
    "name": "Pharmacological management of post-traumatic seizures in adults: current practice patterns in the UK and the Republic of Ireland", 
    "pagination": "457-464", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6d1536cdd791974dbf8bcbe97e04b0d6338a71cc1b070958572232eca47a436a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30276544"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0151000"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00701-018-3683-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1107341092"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00701-018-3683-9", 
      "https://app.dimensions.ai/details/publication/pub.1107341092"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:02", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130830_00000006.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00701-018-3683-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00701-018-3683-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00701-018-3683-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00701-018-3683-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00701-018-3683-9'


 

This table displays all metadata directly associated to this object as RDF triples.

259 TRIPLES      21 PREDICATES      40 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00701-018-3683-9 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author Nd905733c099e41e2bf7ba3284286f14c
4 schema:citation sg:pub.10.1007/s12028-009-9304-y
5 sg:pub.10.1186/s13054-018-2000-6
6 https://doi.org/10.1002/14651858.cd009900.pub2
7 https://doi.org/10.1016/s1474-4422(17)30371-x
8 https://doi.org/10.1046/j.1528-1157.44.s10.4.x
9 https://doi.org/10.1056/nejm199008233230801
10 https://doi.org/10.1111/epi.13470
11 https://doi.org/10.1111/j.1528-1167.2012.03612.x
12 https://doi.org/10.1111/j.1535-7511.2005.00056.x
13 https://doi.org/10.1212/01.wnl.0000125184.88797.62
14 https://doi.org/10.5698/1535-7597-15.2.94
15 schema:datePublished 2019-03
16 schema:datePublishedReg 2019-03-01
17 schema:description BACKGROUND: Patient selection for seizure prophylaxis after traumatic brain injury (TBI) and duration of anti-epileptic drug treatment for patients with early post-traumatic seizures (PTS), remain plagued with uncertainty. In early 2017, a collaborative group of neurosurgeons, neurologists, neurointensive care and rehabilitation medicine physicians was formed in the UK with the aim of assessing variability in current practice and gauging the degree of uncertainty to inform the design of future studies. Here we present the results of a survey of clinicians managing patients with TBI in the UK and Ireland. MATERIALS AND METHODS: An online survey was developed and piloted. Following approval by the Academic Committee of the Society of British Neurological Surgeons, it was distributed via appropriate electronic mailing lists. RESULTS: One hundred and seventeen respondents answered the questionnaire, predominantly neurosurgeons (76%) from 30 (of 32) trauma-receiving hospitals in the UK and Ireland. Fifty-three percent of respondents do not routinely use seizure prophylaxis, but 38% prescribe prophylaxis for one week. Sixty percent feel there is uncertainty regarding the use of seizure prophylaxis, and 71% would participate in further research to address this question. Sixty-two percent of respondents use levetiracetam for treatment of seizures during the acute phase, and 42% continued for a total of 3 months. Overall, 90% were uncertain about the duration of treatment for seizures, and 78% would participate in further research to address this question. CONCLUSION: The survey results demonstrate the variation in practice and uncertainty in both described aspects of management of patients who have suffered a TBI. The majority of respondents would want to participate in future research to help try and address this critical issue, and this shows the importance and relevance of these two clinical questions.
18 schema:genre research_article
19 schema:inLanguage en
20 schema:isAccessibleForFree true
21 schema:isPartOf N3bcc956410c74707adfae639db3975d4
22 Ne23d3f57b59a4d18ae32280332894f8b
23 sg:journal.1356888
24 schema:name Pharmacological management of post-traumatic seizures in adults: current practice patterns in the UK and the Republic of Ireland
25 schema:pagination 457-464
26 schema:productId N3320530022dc4e90bde81010ec5f5814
27 N3c19a393e8044f8aa654ff648420e7ae
28 N644d2568d91f4d4e80662dbbe1a7b8da
29 N6955027387d54622928809fa44f1e37a
30 Nda1ba0998ef34b658bc73cf1ab8cd3f9
31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107341092
32 https://doi.org/10.1007/s00701-018-3683-9
33 schema:sdDatePublished 2019-04-11T14:02
34 schema:sdLicense https://scigraph.springernature.com/explorer/license/
35 schema:sdPublisher Na1e41d4047234335bbb872ff4f73c72e
36 schema:url https://link.springer.com/10.1007%2Fs00701-018-3683-9
37 sgo:license sg:explorer/license/
38 sgo:sdDataset articles
39 rdf:type schema:ScholarlyArticle
40 N1889fd80b8a34a01a60ccd27c1e06f25 rdf:first sg:person.01014411234.64
41 rdf:rest Nc494401f94504b3e975e8b20ff6751ba
42 N315e0fe45aac4afdb11070924f6b6c49 rdf:first sg:person.013101301440.67
43 rdf:rest N518b9a0512d44f49a7bc190c10583f1a
44 N3320530022dc4e90bde81010ec5f5814 schema:name dimensions_id
45 schema:value pub.1107341092
46 rdf:type schema:PropertyValue
47 N3bb5c3558c494edb9cf2fefdcfe2ec97 rdf:first sg:person.01010366215.67
48 rdf:rest Na9302264767e4c95b4406c1e7aeffc3f
49 N3bcc956410c74707adfae639db3975d4 schema:volumeNumber 161
50 rdf:type schema:PublicationVolume
51 N3c19a393e8044f8aa654ff648420e7ae schema:name readcube_id
52 schema:value 6d1536cdd791974dbf8bcbe97e04b0d6338a71cc1b070958572232eca47a436a
53 rdf:type schema:PropertyValue
54 N3ef0a3fed3a24754aba0b802f0378992 rdf:first sg:person.01021135720.25
55 rdf:rest N711afec4e47c4f108e508bcbc85e7a7e
56 N3ff765e057134abe8f3785e059747028 rdf:first sg:person.01145653654.64
57 rdf:rest Ne6ffd00fe075405393a6edb5ecfaf990
58 N4909d0a6b30c4633816e79dbc9df4ec6 rdf:first sg:person.01046534236.90
59 rdf:rest N3bb5c3558c494edb9cf2fefdcfe2ec97
60 N518b9a0512d44f49a7bc190c10583f1a rdf:first sg:person.01072421523.37
61 rdf:rest Ndd868c92cebb4e9289f31f3308c42555
62 N644d2568d91f4d4e80662dbbe1a7b8da schema:name nlm_unique_id
63 schema:value 0151000
64 rdf:type schema:PropertyValue
65 N6955027387d54622928809fa44f1e37a schema:name doi
66 schema:value 10.1007/s00701-018-3683-9
67 rdf:type schema:PropertyValue
68 N711afec4e47c4f108e508bcbc85e7a7e rdf:first sg:person.0636127113.87
69 rdf:rest N7c1decb259264208be1cd66b292d769a
70 N7c1decb259264208be1cd66b292d769a rdf:first sg:person.0673623751.01
71 rdf:rest N3ff765e057134abe8f3785e059747028
72 Na1e41d4047234335bbb872ff4f73c72e schema:name Springer Nature - SN SciGraph project
73 rdf:type schema:Organization
74 Na9302264767e4c95b4406c1e7aeffc3f rdf:first sg:person.01261374732.97
75 rdf:rest N3ef0a3fed3a24754aba0b802f0378992
76 Nbcfdd913a32841f987dd1e39bc560e83 rdf:first sg:person.013407653317.93
77 rdf:rest rdf:nil
78 Nc494401f94504b3e975e8b20ff6751ba rdf:first sg:person.01274163146.14
79 rdf:rest Nf55cea5dca9e48aa87e354521f723011
80 Nd905733c099e41e2bf7ba3284286f14c rdf:first sg:person.015712627754.55
81 rdf:rest Ne714468b05594bb08f43e0144ea44e75
82 Nda1ba0998ef34b658bc73cf1ab8cd3f9 schema:name pubmed_id
83 schema:value 30276544
84 rdf:type schema:PropertyValue
85 Ndd868c92cebb4e9289f31f3308c42555 rdf:first sg:person.01174075734.81
86 rdf:rest Nbcfdd913a32841f987dd1e39bc560e83
87 Ndf43cfc09e93483aadff1c9c08fcce79 rdf:first sg:person.01136462120.63
88 rdf:rest Ne323db9bd75340cea4cb9110665b013a
89 Ne23d3f57b59a4d18ae32280332894f8b schema:issueNumber 3
90 rdf:type schema:PublicationIssue
91 Ne323db9bd75340cea4cb9110665b013a rdf:first sg:person.012277144331.17
92 rdf:rest N4909d0a6b30c4633816e79dbc9df4ec6
93 Ne6ffd00fe075405393a6edb5ecfaf990 rdf:first sg:person.014134741707.15
94 rdf:rest N1889fd80b8a34a01a60ccd27c1e06f25
95 Ne714468b05594bb08f43e0144ea44e75 rdf:first sg:person.0632330025.86
96 rdf:rest Ndf43cfc09e93483aadff1c9c08fcce79
97 Nf55cea5dca9e48aa87e354521f723011 rdf:first sg:person.011162567770.70
98 rdf:rest N315e0fe45aac4afdb11070924f6b6c49
99 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
100 schema:name Medical and Health Sciences
101 rdf:type schema:DefinedTerm
102 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
103 schema:name Neurosciences
104 rdf:type schema:DefinedTerm
105 sg:grant.3795404 http://pending.schema.org/fundedItem sg:pub.10.1007/s00701-018-3683-9
106 rdf:type schema:MonetaryGrant
107 sg:journal.1356888 schema:issn 0001-6268
108 0942-0940
109 schema:name Acta Neurochirurgica
110 rdf:type schema:Periodical
111 sg:person.01010366215.67 schema:affiliation https://www.grid.ac/institutes/grid.120073.7
112 schema:familyName Turner
113 schema:givenName Carole
114 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010366215.67
115 rdf:type schema:Person
116 sg:person.01014411234.64 schema:affiliation https://www.grid.ac/institutes/grid.416928.0
117 schema:familyName McMahon
118 schema:givenName Catherine
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014411234.64
120 rdf:type schema:Person
121 sg:person.01021135720.25 schema:affiliation https://www.grid.ac/institutes/grid.120073.7
122 schema:familyName Coles
123 schema:givenName Jonathan
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021135720.25
125 rdf:type schema:Person
126 sg:person.01046534236.90 schema:affiliation https://www.grid.ac/institutes/grid.11835.3e
127 schema:familyName Lecky
128 schema:givenName Fiona
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046534236.90
130 rdf:type schema:Person
131 sg:person.01072421523.37 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
132 schema:familyName Wilson
133 schema:givenName Mark H.
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072421523.37
135 rdf:type schema:Person
136 sg:person.011162567770.70 schema:affiliation https://www.grid.ac/institutes/grid.416041.6
137 schema:familyName Uff
138 schema:givenName Chris
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011162567770.70
140 rdf:type schema:Person
141 sg:person.01136462120.63 schema:affiliation https://www.grid.ac/institutes/grid.416041.6
142 schema:familyName Chari
143 schema:givenName Aswin
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136462120.63
145 rdf:type schema:Person
146 sg:person.01145653654.64 schema:affiliation https://www.grid.ac/institutes/grid.120073.7
147 schema:familyName Manford
148 schema:givenName Mark
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145653654.64
150 rdf:type schema:Person
151 sg:person.01174075734.81 schema:affiliation https://www.grid.ac/institutes/grid.10025.36
152 schema:familyName Marson
153 schema:givenName Anthony G.
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174075734.81
155 rdf:type schema:Person
156 sg:person.012277144331.17 schema:affiliation https://www.grid.ac/institutes/grid.120073.7
157 schema:familyName Ercole
158 schema:givenName Ari
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012277144331.17
160 rdf:type schema:Person
161 sg:person.01261374732.97 schema:affiliation https://www.grid.ac/institutes/grid.10025.36
162 schema:familyName Tudur-Smith
163 schema:givenName Catrin
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261374732.97
165 rdf:type schema:Person
166 sg:person.01274163146.14 schema:affiliation https://www.grid.ac/institutes/grid.123047.3
167 schema:familyName Bulters
168 schema:givenName Diederik
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274163146.14
170 rdf:type schema:Person
171 sg:person.013101301440.67 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
172 schema:familyName Duncan
173 schema:givenName John S.
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013101301440.67
175 rdf:type schema:Person
176 sg:person.013407653317.93 schema:affiliation https://www.grid.ac/institutes/grid.120073.7
177 schema:familyName Hutchinson
178 schema:givenName Peter J.
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013407653317.93
180 rdf:type schema:Person
181 sg:person.014134741707.15 schema:affiliation https://www.grid.ac/institutes/grid.120073.7
182 schema:familyName Ham
183 schema:givenName Timothy
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014134741707.15
185 rdf:type schema:Person
186 sg:person.015712627754.55 schema:affiliation https://www.grid.ac/institutes/grid.120073.7
187 schema:familyName Mee
188 schema:givenName Harry
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015712627754.55
190 rdf:type schema:Person
191 sg:person.0632330025.86 schema:affiliation https://www.grid.ac/institutes/grid.120073.7
192 schema:familyName Kolias
193 schema:givenName Angelos G.
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632330025.86
195 rdf:type schema:Person
196 sg:person.0636127113.87 schema:affiliation https://www.grid.ac/institutes/grid.120073.7
197 schema:familyName Anwar
198 schema:givenName Fahim
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636127113.87
200 rdf:type schema:Person
201 sg:person.0673623751.01 schema:affiliation https://www.grid.ac/institutes/grid.415490.d
202 schema:familyName Belli
203 schema:givenName Antonio
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673623751.01
205 rdf:type schema:Person
206 sg:pub.10.1007/s12028-009-9304-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1023684260
207 https://doi.org/10.1007/s12028-009-9304-y
208 rdf:type schema:CreativeWork
209 sg:pub.10.1186/s13054-018-2000-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103231296
210 https://doi.org/10.1186/s13054-018-2000-6
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1002/14651858.cd009900.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036877113
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/s1474-4422(17)30371-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1092557000
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1046/j.1528-1157.44.s10.4.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014111243
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1056/nejm199008233230801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004278701
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1111/epi.13470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012917488
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1111/j.1528-1167.2012.03612.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049522550
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1111/j.1535-7511.2005.00056.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052897271
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1212/01.wnl.0000125184.88797.62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064345968
227 rdf:type schema:CreativeWork
228 https://doi.org/10.5698/1535-7597-15.2.94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073075420
229 rdf:type schema:CreativeWork
230 https://www.grid.ac/institutes/grid.10025.36 schema:alternateName University of Liverpool
231 schema:name Department of Biostatistics, University of Liverpool, Merseyside, Liverpool, UK
232 Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
233 rdf:type schema:Organization
234 https://www.grid.ac/institutes/grid.11835.3e schema:alternateName University of Sheffield
235 schema:name School of Health and Related Research, University of Sheffield, Sheffield, UK
236 rdf:type schema:Organization
237 https://www.grid.ac/institutes/grid.120073.7 schema:alternateName Addenbrooke's Hospital
238 schema:name Department of Clinical Neurosciences, University of Cambridge & Addenbrooke’s Hospital, Cambridge, UK
239 Neurosciences Critical Care Unit and Division of Anaesthesia, University of Cambridge & Addenbrooke’s Hospital, Cambridge, UK
240 Surgery theme, Cambridge Clinical Trials Unit, Cambridge, UK
241 rdf:type schema:Organization
242 https://www.grid.ac/institutes/grid.123047.3 schema:alternateName Southampton General Hospital
243 schema:name Department of Neurosurgery, University Hospital Southampton, Southampton, UK
244 rdf:type schema:Organization
245 https://www.grid.ac/institutes/grid.415490.d schema:alternateName Queen Elizabeth Hospital Birmingham
246 schema:name Department of Neurosurgery, Queen Elizabeth Hospital, Birmingham, UK
247 rdf:type schema:Organization
248 https://www.grid.ac/institutes/grid.416041.6 schema:alternateName Royal London Hospital
249 schema:name Department of Neurosurgery, Royal London Hospital, London, UK
250 rdf:type schema:Organization
251 https://www.grid.ac/institutes/grid.416928.0 schema:alternateName Walton Centre
252 schema:name Department of Neurosurgery, The Walton Centre, Liverpool, UK
253 rdf:type schema:Organization
254 https://www.grid.ac/institutes/grid.7445.2 schema:alternateName Imperial College London
255 schema:name Imperial Neurotrauma Centre, Department of Surgery & Cancer, Imperial College, London, UK
256 rdf:type schema:Organization
257 https://www.grid.ac/institutes/grid.83440.3b schema:alternateName University College London
258 schema:name Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK
259 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...